ATC Abstracts

American Transplant Congress abstracts

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  • 2018 American Transplant Congress

    Low Intensity Conditioning Protocol for Inducing Chimerism-Based Tolerance in Non-Obese Diabetic Mice

    A. Chhabra, Y. Huang, H. Xu, A. Merchak, S. Ildstad.

    Institute for Cellular Therapeutics, University of Louisville, Louisville, KY.

    Type 1 diabetes is the most common chronic disease affecting children. Islet cell or pancreas transplantation offer the most physiologic approach to glucose homostasis. However…
  • 2018 American Transplant Congress

    Improved Mouse Renal Transplantation Model Mimicking Clinical Antibody Mediated Rejection

    D. Zhao,1 T. Liao,1 S. Li,1 J. Zhou,2 F. Han,1 Y. Dong,3 Q. Sun.1

    1Organ Transplantation Institution, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; 2Department of Pathology, Third Affiliated Hospital of Sun Yat-sen University, Guanghzou, Guangdong, China; 3Department of Pathology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

    Antibody mediated rejection (AMR) is main barrier to long term renal graft survival and mouse model is important to understand the mechanisms of AMR and…
  • 2018 American Transplant Congress

    Involvement of PD-L1 Upregulation in Anti-A/B Antibody-Induced Graft Accommodation: Reduction of CD4 T Cell Allo-Response against Graft HLA Class II DR

    K. Iwasaki,1 Y. Miwa,1 H. Hamana,3 H. Kishi,3 A. Muraguchi,3 K. Uchida,1 T. Kobayashi.2

    1Kidney Disease and Transplant Immunology, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan; 2Renal Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan; 3Immunology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.

    [Background] Antibodies against transplanted organs cause complement-independent graft injury, but there remain many unknown aspects of its mechanism, in particular its effect on allo-response to…
  • 2018 American Transplant Congress

    Assessing Response to Desensitization: What Makes Sense?

    E. Kransdorf, J. Patel, M. Kittleson, R. Levine, S. Dimbil, D. Geft, D. Chang, L. Czer, J. Kobashigawa.

    Cedars Sinai Medical Center, Los Angeles.

    Purpose: Sensitized candidates experience prolonged waiting times for heart transplant (HT). Desensitization therapies can increase access to HT for sensitized candidates, but changes in calculated…
  • 2018 American Transplant Congress

    Extracorporeal Membrane Oxygenation Experience for Graft Failure after Heart Transplantation

    S. Lehmann, K. Jawad, S. Feder, A. Meyer, M. Dieterlen, J. Fischer, J. Garbade, M. Borger.

    Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany.

    INTRODUCTION:Acute graft failure is the leading cause of early mortality after heart transplantation (HTX). Extracorporeal membrane oxygenation (ECMO) is a therapy option to treat heart…
  • 2018 American Transplant Congress

    The Study of the Influence on hIAPP Deposition and Dysfunction in INS-1 Cell by Calcineurin Inhibitors

    J. Zhang, W. Lv, C. Zhang, N. Sun, X. Li, Y. Shi, A. Jiao, J. Lin, Y. Lv.

    Hepatobiliary Surgery Department and Unit of Organ Transplantation, The First Hospital of China Medical University, Shenyang, Liaoning, China.

    Background hIAPP is formed in islet β cells, misfolded hIAPP results in the deposition inside the β-cells and shows a damage to the β-cells. The…
  • 2018 American Transplant Congress

    Non-Immunologic Pairing of Kidney Transplant Donors and Recipients: How Important is HLA Match Status?

    A. Miller, B. Kiberd, K. Tennankore.

    Division of Nephrology, Department of Medicine, Dalhousie University, Halifax, NS, Canada.

    Currently, allocation preference in deceased donor kidney transplantation is given to donors and recipients (D/R) with 0 human leukocyte antigen (HLA) mismatches (MM), with non-immunologic…
  • 2018 American Transplant Congress

    A Calculated Panel Reactive Antibody (CPRA) Calculator Supporting Both Allele-Level and Antigen-Level HLA Specificities

    L. Gragert,1,2 E. Kransdorf,3 N. Kaur,1 M. Maiers,2 J. Kobashigawa,3 M. Pando.4

    1Tulane University School of Medicine, New Orleans; 2National Marrow Donor Program / Be The Match, Minneapolis; 3Cedars-Sinai Heart Institute, Los Angeles; 4Baylor Scott and White, Temple.

    Introduction:The number of HLA alleles represented on Luminex assays has increased over time, allowing for improved characterization of anti-HLA antibody specificity. Calculated Panel Reactive Antibody…
  • 2018 American Transplant Congress

    Effect of rATG on Monocytic Myeloid-Derived Suppressor Cells and Its Associated Mechanisms in Kidney Transplantation Recipients

    Y. Jiang, X. Zhang.

    Beijing Chao-Yang Hospital, Beijing, China.

    Myeloid-derived suppressor cells (MDSCs) consist of heterogeneous myeloid progenitors and precursors that was first defined in cancer patients and are characterized by a regulatory ability…
  • 2018 American Transplant Congress

    Risk of Bacteremia According to Transplant Induction Immunosuppression Regimen

    E. Misch, S. Kelley, G. Leverson, B. Astor, D. Kaufman.

    University of Wisconsin School of Medicine and Public Health, Madison.

    Background: Transplant immune suppression is designed to suppress the adaptive immune response and ensure graft survival, but may have unintended effects on innate immunity. Few…
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