2018 American Transplant Congress
Impact of Local Liver Supply on Liver Offer Acceptance
1JHU, Baltimore; 2US Naval Academy, Annapolis.
Geographic disparity in access to deceased-donor liver transplantation is well described. The available liver supply in a DSA may affect patient and provider decisions on…2018 American Transplant Congress
T Cell-Mediated Rejection Poses Greater Risk to Graft Survival Than Antibody-Mediated Rejection in Heart Transplants
University of Alberta, Edmonton, Canada.
Purpose: In kidney transplants, failure post-biopsy is associated with acute injury transcript expression reflecting the histologically silent tissue response-to-wounding (JCI 120:1862) and antibody-mediated rejection (ABMR),…2018 American Transplant Congress
The Incidence of Polyomavirus-BK and Cytomegalovirus Infections in Renal Transplant Recipients Following Rituximab Administration
Northwestern Memorial Hospital, Chicago, IL.
Rituximab is an antibody that binds to the CD20 antigen on B cells resulting in rapid and prolonged depletion. At Northwestern Memorial Hospital, a single…2018 American Transplant Congress
Extracellular Microvesicles from Liver Perfusate: microRNAs, Cellular Cross-Talk, and Early-Post Liver Transplant Outcomes
1Surgery, UVA, Charlottesville; 2Nephrology Division, UVA, Charlottesville.
Background: Ischemia reperfusion injury (IRI) is a multifactorial process that impact liver graft function. Donor quality plays a critical role during IRI and early graft…2018 American Transplant Congress
Nephrosclerosis beyond That Expected for Age is Predictive of Early New-Onset Hypertension (HTN) in Living Kidney Donors (LKD)
1Mayo Clinic, Rochester, MN; 2Mayo Clinic, Scottsdale, AZ; 3Cleveland Clinic, Cleveland, OH.
Background: Nephrosclerosis on biopsy (bx) of LKD is associated with older age & HTN. We studied whether nephrosclerosis is predictive of adverse changes early after…2018 American Transplant Congress
Low Kidney Supply to Demand Ratio and Multi-Organ Transplant Centers Are Negatively Associated with Pediatric Renal Transplant Rates Post Kidney Allocation System Implementation: An Analysis of OPTN Data
Under the new kidney allocation system (KAS), pediatric (PED) renal (REN) transplant (Tx) candidates have priority to kidneys from donors with KDPI < 35%. We…2018 American Transplant Congress
Direct-Acting Antiviral Therapy Immune-Mediated Graft Dysfunction in Liver Transplant Recipients with Hepatitis C
Background and Aims:Interferon (IFN) treatment of hepatitis C virus (HCV) infection after liver transplantation (LT) can result in severe immune-mediated graft dysfunction (IGD). The occurrence…2018 American Transplant Congress
RNA-Seq Based Analysis of Renal Allograft Biopsies Reveals Key Mediators of Interstitial Fibrosis/Tubular Atrophy
Interstitial Fibrosis/Tubular Atrophy(IFTA) is the final common pathway of most progressive renal diseases and is a potent predictors of renal outcome in both native and…2018 American Transplant Congress
The MicroRNA Landscape of EBV+ and EBV- PTLD
Post-transplant lymphoproliferative disorder (PTLD) is a potentially fatal complication of organ transplantation characterized by abnormal proliferation of lymphoid cells in the setting of immunosuppression after…2018 American Transplant Congress
Contribution of mTOR Signaling to the β-Catenin Pathway in Regulatory T Cells
Surgery, University of Kentucky, Lexington, KY.
Background: A growing body of evidence recognizes the balance between graft-reactive effector T cells and graft-protective regulatory T cells (Tregs) as the ultimate determinant of…
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