Am J Transplant, Volume 18, Suppl 3 Archives - Page 66 of 211 - ATC Abstracts

2018 American Transplant Congress
Role of C1q-Binding Donor-Specific Anti-HLA Antibodies in Premature and Accelerated Kidney Allograft Interstitial Fibrosis
K. Louis, D. Viglietti, O. Aubert, A. Loupy, C. Lefaucheur.
Paris Translational Research Center for Organ Transplantation, Paris, France.
The 2017 Banff meeting has focused on the importance of a precise diagnosis of IF/TA in kidney recipients by addressing specific etiological factors. Recent studies…
2018 American Transplant Congress
RNA Expression Profiling of Renal Allografts in the Cynomolgus Monkey Identifies Tolerance
R. Smith,¹ M. Matsunami,³ B. Adam,² A. Rosales,¹ T. Oura,³ A. Cosimi,³ T. Kawai,³ M. Mengel,² R. Colvin.¹
¹Pathology, Massachusetts General Hospital, Boston, MA; ²Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; ³Department of Surgery, Massachusetts General Hospital, Boston, MA.
IntroductionTolerance induction is a long standing clinical goal. However, identification remains elusive. Here we profile intra-renal allograft RNA expression in a mixed chimerism renal allograft…
2018 American Transplant Congress
Rituximab Interference in B-Cell Crossmatch: A Problem Solved
P. Malvezzi,¹ O. Senoussi,² T. Jouve,¹ C. De Palma,² L. Rostaing,¹ B. Bardy,² D. Masson.²
¹Service de Néphrologie, Dialyse, Aphérèses et Transplantation, CHU Grenoble Alpes, Grenoble, France; ²Laboratoire d'Histocompatibilité, EFS Rhone Alpes, Grenoble, France.
Background: Rituximab is commonly prescribed in ABO- or HLA-incompatible kidney transplantation. When used before transplant it interferes with B lymphocyte complement-dependent crossmatch (CDC CM) or…
2018 American Transplant Congress
A 3C Approach Drives Epigenetic Fixation of Foxp3 Expression and Stabilizes Treg Cell Lineage and Therapeutic Function
X. Xiao, X. Zhang, J. Li, S. Chen, P. Lan, Y. Dou, W. Chen, X. Li.
Immunobiology & Transplant Research Center, Houston Methodist Hospital, Houston, TX.
The instability of the regulatory T (Treg) cell lineage precludes their therapeutic potential in transplantation and autoimmune diseases. Herein, we invented a novel approach to…
2018 American Transplant Congress
Cost Impacts of Alternative Kidney Transplant Immunosuppression: A National Cohort Study
K. Lentine,¹ D. Axelrod,² V. Dharnidharka,³ H. Xiao,¹ D. Brennan,⁴ D. Segev,⁴ H. Randall,¹ R. Ouseph,¹ A. Naik,⁵ N. Lam,⁶ T. Alhamad,³ B. Kasiske,⁷ G. Hess,⁸ M. Schnitzler.¹
¹Saint Louis Univ, St. Louis; ²Lahey Clinic, Burlington; ³Washington Univ, St. Louis; ⁴Johns Hopkins, Baltimore; ⁵Univ Michigan, Ann Arbor; ⁶Univ Alberta, Edmonton, Canada; ⁷Hennepin County, Minneapolis; ⁸Symphony Health, Conshohocken.
Economic outcomes are increasingly considered along with clinical efficacy to guide choice of alternative therapies. We examined the cost impact of kidney transplant (KTx) induction…
2018 American Transplant Congress
Long Term Histologic Allograft Health is Preserved Despite Rejection during Protocolized Immunosuppression Withdrawal (ISW) in Stable Pediatric Liver Transplant Recipients
V. Venkat,¹ J. Bucuvalas,² M. Martinez,³ K. Spain,⁴ G. Mazariegos,¹ A. Demetris,⁵ S. Feng.⁶
¹Children's Hospital, Pittsburgh; ²CCHMC, Cincinnati; ³Columbia, NY; ⁴Rho, Chapel Hill; ⁵UPMC, Pittsburgh; ⁶UCSF, San Francisco.
Background: Long term allograft health after rejection during ISW has not been previously assessed. We compare baseline and 4yr graft histology of 20 rejectors in…
2018 American Transplant Congress
Longitudinal Molecular Assessment of Renal Allograft and Short-Term Outcome: Markers of Injury and Recovery
S. Bontha,¹ A. Fernandez,¹ E. Bardhi,¹ L. Gallon,² V. Mas,¹ D. Maluf.¹
¹Surgery, UVA, Charlottesville; ²NWU, Chicago.
Background: Ischemia reperfusion (I/R) is influenced by both donor and recipient characteristics and affects early graft function and the recovery process. To understand underlying mechanisms…
2018 American Transplant Congress
Association of Leptin with Cystatin C in Kidney Allograft Dysfunction
A. Bera,¹ M. Watson,² N. Gana,¹ J. Karaian,¹ S. Radhakrishnan,¹ M. Subramanian,¹ D. Little,² R. Nee,² A. Chatterjee,¹ S. Rothwell,¹ H. Pollard,¹ R. Jindal,³ M. Srivastava.¹
¹Anatomy, Physiology and Genetics, USU-School of Medicine, Bethesda, MD; ²Nephrology, USU-Walter Reed, Bethesda, MD; ³Surgery, USU-Walter Reed, Bethesda, MD.
Background: Non-invasive biomarkers are needed for monitoring recipients of kidney allografts to predict acute rejection (AR). We hypothesized that protein biomarkers released from rejecting allograft…
2018 American Transplant Congress
Time and Perfusate Dependent Molecular Response in Ex Vivo Lung Perfusion
P. Dromparis,¹ N. Aboelnazar,² S. Wagner,¹ S. Himmat,² C. White,² J. Luc,² D. Freed,² J. Nagendran,² M. Mengel,¹ B. Adam.¹
¹Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada; ²Department of Surgery (Cardiac), University of Alberta, Edmonton, Canada.
Lung transplantation has limited organ utilization and high rates of primary graft dysfunction, in part due to acute lung injury (ALI). Cold static preservation (CSP)…
2018 American Transplant Congress
A Novel Preservation Solution for Lung That Improves Cell Viability and Tissue Architecture
J. Friedman,¹ M. Samamrco,¹ L. Marrero,¹ B. Bunnell,¹ D. Spyropoulos.²
¹Tulane University, New Orleans; ²MUSC, Charleston.
Backgroud: Only 20% of donor lungs are used for transplant and 10 y survival of recipients is low. Many patients die within 30 d of…