Weight Changes before and after Kidney Donation
1Medicine, The Ottawa Hospital, Ottawa, ON, Canada
2Faculty of Science, University of Ottawa, Ottawa, ON, Canada.
Meeting: 2018 American Transplant Congress
Abstract number: D294
Keywords: Donation, Kidney transplantation, Obesity
Session Information
Date: Tuesday, June 5, 2018
Session Name: Poster Session D: Late Breaking
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall 4EF
Introduction
Living kidney donors remain at low risk of end stage kidney disease but obese and overweight donors' risk is increased. We aimed to describe the trajectory of weight (wt) changes pre/post donation to aid in donor risk assessment.
Methods
A single center retrospective chart review from 1/2009 – 12/2017 was performed. Demographics, height and wt measures from hospital and clinic visits were collected. Patients were categorized by BMI (kg/m2) at time of donation. Mean wt at time of initial assessment, kidney donation, 12 mos follow-up and last follow-up were calculated. Paired t-tests compared mean differences in wt at kidney donation relative to other time points.
Results
195 donors were included for analysis. Mean (SD) age was 47±13 years and 73% were female. At donation, 2 patients (1.0%) had BMI <18.5 kg/m2 (underwt); 49 (25.1%) BMI 18.5-24.9 (healthy wt); 85 (43.6%) BMI 25-29.9 (overwt); 46 (23.6%) BMI 30-34.9 (Class 1 Obesity); 13 (6.7%) BMI 35-39.9 (Class 2 Obesity). Wt loss occurred prior to donation in the BMI 18.5-24.9 group and did not change post-donation. Significant wt gain occurred post-donation in patients with BMI ≥ 25 at baseline (P<0.0001).
| BMI 18.5-24.9 n=49 | BMI ≥ 25 n=144 | Overall | ||||
| Mean wt (SD) (kg) | Mean Diff (SD), P vs REF value | Mean wt (SD) (kg) | Mean Diff (SD), P vs REF value | Mean wt (SD) (kg) | Mean Diff (SD), P vs REF value | |
| Inital Assessment (n=195) | 63.9 (9.8) | 1.1 (2.7), 0.004 | 85.4 (12.1) | 0.28 (3.3), 0.30 | 79.5 (15.4) | 0.49 (3.1), 0.028 |
| Kidney Donation (n=195) | 62.7 (9.1) | REFERENCE | 85.1 (11.8) | REFERENCE | 79.0 (15.3) | REFERENCE |
| 12 Month Follow-up (n=100) | 62.2 (11.1) | -1.1 (2.8), 0.07 | 88.5 (13.2) | 2.5 (4.6), <0.0001 | 81.9 (17.5) | 2.3 (4.5), <0.0001 |
| Last Follow-up (n=151) | 62.6 (9.7) | -0.85 (3.9), 0.21 | 88.4 (13.3) | 2.6 (5.9), <0.0001 | 81.8 (17.2) | 2.3 (5.6), <0.0001 |
Conclusions
Despite KDIGO recommendations that overwt and obese patients pursue wt loss pre-donation and donors maintain a healthy wt after donation, this is not what occurred. Significant wt gain occurred in patients with BMI ≥ 25 at baseline. This finding may influence donor risk assessment. Our results highlight the need for effective wt loss interventions both pre- and post-donation.
CITATION INFORMATION: Bugeja A., Harris S., Ernst J., Burns K. D., Knoll G., Clark E. G. Weight Changes before and after Kidney Donation Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Bugeja A, Harris S, Ernst J, Burns KD, Knoll G, Clark EG. Weight Changes before and after Kidney Donation [abstract]. https://atcmeetingabstracts.com/abstract/weight-changes-before-and-after-kidney-donation/. Accessed November 11, 2019.« Back to 2018 American Transplant Congress