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Weight Changes before and after Kidney Donation

A. Bugeja,1 S. Harris,2 J. Ernst,1 K. D. Burns,1 G. Knoll,1 E. G. Clark.1

1Medicine, The Ottawa Hospital, Ottawa, ON, Canada
2Faculty of Science, University of Ottawa, Ottawa, ON, Canada.

Meeting: 2018 American Transplant Congress

Abstract number: D294

Keywords: Donation, Kidney transplantation, Obesity

Session Information

Date: Tuesday, June 5, 2018

Session Name: Poster Session D: Late Breaking

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Hall 4EF

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  • Pre-Donation Weight Loss Postpones Living Kidney Donation without Attaining the Desired Weight Maintenance in the Midterm.
  • What Is the Implication of Pre-Donation Weight Loss to the Post-Donation Weight and Outcome of Living Donors

Introduction

Living kidney donors remain at low risk of end stage kidney disease but obese and overweight donors' risk is increased. We aimed to describe the trajectory of weight (wt) changes pre/post donation to aid in donor risk assessment.

Methods

A single center retrospective chart review from 1/2009 – 12/2017 was performed. Demographics, height and wt measures from hospital and clinic visits were collected. Patients were categorized by BMI (kg/m2) at time of donation. Mean wt at time of initial assessment, kidney donation, 12 mos follow-up and last follow-up were calculated. Paired t-tests compared mean differences in wt at kidney donation relative to other time points.

Results

195 donors were included for analysis. Mean (SD) age was 47±13 years and 73% were female. At donation, 2 patients (1.0%) had BMI <18.5 kg/m2 (underwt); 49 (25.1%) BMI 18.5-24.9 (healthy wt); 85 (43.6%) BMI 25-29.9 (overwt); 46 (23.6%) BMI 30-34.9 (Class 1 Obesity); 13 (6.7%) BMI 35-39.9 (Class 2 Obesity). Wt loss occurred prior to donation in the BMI 18.5-24.9 group and did not change post-donation. Significant wt gain occurred post-donation in patients with BMI ≥ 25 at baseline (P<0.0001).

BMI 18.5-24.9

n=49

BMI ≥ 25

n=144

Overall
Mean wt (SD)

(kg)

Mean Diff (SD), P vs REF value Mean wt (SD)

(kg)

Mean Diff (SD), P vs REF value Mean wt (SD)

(kg)

Mean Diff (SD), P vs REF value
Inital Assessment (n=195) 63.9 (9.8) 1.1 (2.7), 0.004 85.4 (12.1) 0.28 (3.3), 0.30 79.5 (15.4) 0.49 (3.1), 0.028
Kidney Donation (n=195) 62.7 (9.1) REFERENCE 85.1 (11.8) REFERENCE 79.0 (15.3) REFERENCE
12 Month Follow-up (n=100) 62.2 (11.1) -1.1 (2.8), 0.07 88.5 (13.2) 2.5 (4.6), <0.0001 81.9 (17.5) 2.3 (4.5), <0.0001
Last Follow-up (n=151) 62.6 (9.7) -0.85 (3.9), 0.21 88.4 (13.3) 2.6 (5.9), <0.0001 81.8 (17.2) 2.3 (5.6), <0.0001

Conclusions

Despite KDIGO recommendations that overwt and obese patients pursue wt loss pre-donation and donors maintain a healthy wt after donation, this is not what occurred. Significant wt gain occurred in patients with BMI ≥ 25 at baseline. This finding may influence donor risk assessment. Our results highlight the need for effective wt loss interventions both pre- and post-donation.

CITATION INFORMATION: Bugeja A., Harris S., Ernst J., Burns K. D., Knoll G., Clark E. G. Weight Changes before and after Kidney Donation Am J Transplant. 2017;17 (suppl 3).

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To cite this abstract in AMA style:

Bugeja A, Harris S, Ernst J, Burns KD, Knoll G, Clark EG. Weight Changes before and after Kidney Donation [abstract]. https://atcmeetingabstracts.com/abstract/weight-changes-before-and-after-kidney-donation/. Accessed January 23, 2021.

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