Am J Transplant, Volume 18, Suppl 3 Archives - Page 60 of 211 - ATC Abstracts

2018 American Transplant Congress
Human CD8⁺CD28^– T Cells Driven In Vitro by IL-15 Suppress in Allo-Specific Manner Partially through PD-1:PD-L1 Pathway
F. Feng,^1,2 G. Liu,¹ P. Zhu,¹ M. Zhu,¹ X. Lu,¹ J. Liu,² X. Luo,³ Y. Liu,¹ Y. Yu.²
¹Department of Immunology, School of Basic Medical Science, Southern Medical University, Guangzhou, Guangdong, China; ²Department of Urology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China; ³Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.
Background: CD8+CD28- T suppressor cells (Ts) have emerged as an important modulator of alloimmunity, but the in vitro inducibility of Ts subsets is rather unclear.…
2018 American Transplant Congress
IL23R is a Pathogenic Gene in Type 1 Regulatory T Cells during Mouse Cardiac Transplantation Models
G. Gu, T. Lu, N. Xu, Q. Xia.
Department of Liver Surgery, Renji Hospital, Affiliated by Shanghai Jiaotong University School of Medicine, Shanghai, China.
IL23R has been confirmed to be a pathogenic gene in Th17 cells. However, its role in type 1 regulatory T cells (Tr1 cells) is not…
2018 American Transplant Congress
Low Intensity Conditioning Protocol for Inducing Chimerism-Based Tolerance in Non-Obese Diabetic Mice
A. Chhabra, Y. Huang, H. Xu, A. Merchak, S. Ildstad.
Institute for Cellular Therapeutics, University of Louisville, Louisville, KY.
Type 1 diabetes is the most common chronic disease affecting children. Islet cell or pancreas transplantation offer the most physiologic approach to glucose homostasis. However…
2018 American Transplant Congress
Improved Mouse Renal Transplantation Model Mimicking Clinical Antibody Mediated Rejection
D. Zhao,¹ T. Liao,¹ S. Li,¹ J. Zhou,² F. Han,¹ Y. Dong,³ Q. Sun.¹
¹Organ Transplantation Institution, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; ²Department of Pathology, Third Affiliated Hospital of Sun Yat-sen University, Guanghzou, Guangdong, China; ³Department of Pathology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Antibody mediated rejection (AMR) is main barrier to long term renal graft survival and mouse model is important to understand the mechanisms of AMR and…
2018 American Transplant Congress
Involvement of PD-L1 Upregulation in Anti-A/B Antibody-Induced Graft Accommodation: Reduction of CD4 T Cell Allo-Response against Graft HLA Class II DR
K. Iwasaki,¹ Y. Miwa,¹ H. Hamana,³ H. Kishi,³ A. Muraguchi,³ K. Uchida,¹ T. Kobayashi.²
¹Kidney Disease and Transplant Immunology, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan; ²Renal Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan; ³Immunology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
[Background] Antibodies against transplanted organs cause complement-independent graft injury, but there remain many unknown aspects of its mechanism, in particular its effect on allo-response to…
2018 American Transplant Congress
Assessing Response to Desensitization: What Makes Sense?
E. Kransdorf, J. Patel, M. Kittleson, R. Levine, S. Dimbil, D. Geft, D. Chang, L. Czer, J. Kobashigawa.
Cedars Sinai Medical Center, Los Angeles.
Purpose: Sensitized candidates experience prolonged waiting times for heart transplant (HT). Desensitization therapies can increase access to HT for sensitized candidates, but changes in calculated…
2018 American Transplant Congress
Extracorporeal Membrane Oxygenation Experience for Graft Failure after Heart Transplantation
S. Lehmann, K. Jawad, S. Feder, A. Meyer, M. Dieterlen, J. Fischer, J. Garbade, M. Borger.
Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany.
INTRODUCTION:Acute graft failure is the leading cause of early mortality after heart transplantation (HTX). Extracorporeal membrane oxygenation (ECMO) is a therapy option to treat heart…
2018 American Transplant Congress
The Study of the Influence on hIAPP Deposition and Dysfunction in INS-1 Cell by Calcineurin Inhibitors
J. Zhang, W. Lv, C. Zhang, N. Sun, X. Li, Y. Shi, A. Jiao, J. Lin, Y. Lv.
Hepatobiliary Surgery Department and Unit of Organ Transplantation, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Background hIAPP is formed in islet β cells, misfolded hIAPP results in the deposition inside the β-cells and shows a damage to the β-cells. The…
2018 American Transplant Congress
Non-Immunologic Pairing of Kidney Transplant Donors and Recipients: How Important is HLA Match Status?
A. Miller, B. Kiberd, K. Tennankore.
Division of Nephrology, Department of Medicine, Dalhousie University, Halifax, NS, Canada.
Currently, allocation preference in deceased donor kidney transplantation is given to donors and recipients (D/R) with 0 human leukocyte antigen (HLA) mismatches (MM), with non-immunologic…
2018 American Transplant Congress
A Calculated Panel Reactive Antibody (CPRA) Calculator Supporting Both Allele-Level and Antigen-Level HLA Specificities
L. Gragert,^1,2 E. Kransdorf,³ N. Kaur,¹ M. Maiers,² J. Kobashigawa,³ M. Pando.⁴
¹Tulane University School of Medicine, New Orleans; ²National Marrow Donor Program / Be The Match, Minneapolis; ³Cedars-Sinai Heart Institute, Los Angeles; ⁴Baylor Scott and White, Temple.
Introduction:The number of HLA alleles represented on Luminex assays has increased over time, allowing for improved characterization of anti-HLA antibody specificity. Calculated Panel Reactive Antibody…