Am J Transplant, Volume 18, Suppl 3 Archives - Page 51 of 211 - ATC Abstracts

2018 American Transplant Congress
Genome-Wide Association Study of Tacrolimus Dose in Pediatric Solid Organ Transplant Recipients in the CNTRP POSITIVE Study
S. Min,¹ T. Papaz,¹ T. Blydt-Hansen,³ O. Lee,¹ U. Allen,¹ P. Birk,² H. Grasemann,¹ L. Hamiwka,⁴ C. Litalien,⁵ V. Ng,¹ R. Parekh,¹ K. Tinckam,⁶ S. Urschel,⁷ B. Foster,⁸ S. Mital.¹
¹The Hospital for Sick Children, Toronto, Canada; ²Winnipeg Children's Hospital, Winnipeg, Canada; ³BC Children's Hospital, Vancouver, Canada; ⁴Alberta Children's Hospital, Calgary, Canada; ⁵CHU Ste-Justine, Montreal, Canada; ⁶University Health Network, Toronto, Canada; ⁷Stollery Children's Hospital, Edmonton, Canada; ⁸Montreal Children's Hospital, Montreal, Canada.
PURPOSE: There are significant challenges in achieving therapeutic tacrolimus (Tac) concentrations after transplant. We explored variants associated with tacrolimus dose requirements in pediatric solid organ…
2018 American Transplant Congress
Primary Insult to the Native Lungs Are Needed for Antibodies to Lung Self-Antigens, Kα1Tubulin and Collagen V, to Be Pathogenic for the Development of Obliterate Airway Disease
M. Sharma, W. Liu, T. Mohanakumar.
Norton Thoracic Institute, St. Joseph's Hospital & Medical Center, Phoenix.
Introduction: Antibodies (Abs) to lung self-antigens (SAgs) have been correlated with development of bronchiolitis obliterans syndrome following human lung transplantation. Further, administration of Abs to…
2018 American Transplant Congress
Endothelin A Receptor (ETaR) siRNA Ameliorates Renal Ischemia Reperfusion Injury through Upregulating Expression of eNOS in Rats
Y. Jia, L. Li, T. Zhu.
Shanghai Key Labratory of Organ Transplantation, Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China.
Aims: To explore the protective effect of Endothelin A Receptor (ETaR) siRNA on renal ischemia reperfusion injury and its underlying mechanism.Methods: The model of unilateral…
2018 American Transplant Congress
Impact of Sleep Apnea Syndrome on Late Graft Dysfunction
A. Afzal,¹ K. Tecson,² A. Jamil,³ A. Wazir,¹ J. Felius,³ H. Qin,³ P. Garcha,¹ S. Carey,¹ S. Hall.¹
¹Center for Advanced Heart and Lung Disease, Baylor University Medical Center, Dallas, TX; ²Baylor Heart and Vascular Institute, Baylor Scott & White Research Institute, Dallas, TX; ³Annette C. and Harold C. Simmons Transplant Institute, Baylor Scott & White Research Institute, Dallas, TX.
Background: Sleep apnea syndrome (SAS) is associated with higher risk of stroke, cardiovascular events, arrhythmias, hypertension, and congestive heart failure. However, there is a paucity…
2018 American Transplant Congress
Institution-Based, Pharmacist-Managed Anticoagulation in Patients with a Left Ventricular Assist Device
T. Bibb,¹ L. Halder,¹ D. McDanel,¹ A. Briasoulis,² P. Alvarez,² K. Horner,¹ J. Bhama,³ S. Larson.³
¹Department of Pharmaceutical Care, University of Iowa Hospitals and Clinics, Iowa City, IA; ²Division of Cardiovascular Medicine, Department of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA; ³Division of Cardiothoracic Surgery, Department of Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA.
Long-term anticoagulation with warfarin is required for patients with left ventricular assist devices (LVADs). There is limited data of time in therapeutic range (TTR) in…
2018 American Transplant Congress
Extracellular Matrix from Pancreas Improves Human Islet Function In Vitro
Y. Shindo,¹ R. Pouillot,² B. Young,² P. Link,² R. Heise,² M. Levy,^1,3 M. Kanak.¹
¹Department of Surgery, School of Medicine, Virginia Commonwealth University, Richmond; ²Department of Biomedical Engineering, Virginia Commonwealth University, Richmond; ³Hume-Lee Transplant Center, VCU Health System, Richmond.
Background:Islets which are clinically transplanted into the portal vein are subjected to inflammatory insults in the peri-transplant period followed by immune assault causing long-term islet…
2018 American Transplant Congress
A New Reality: Virtual Crossmatch Can Be Used Successfully as Pre-Transplant Compatibility Testing for Most Deceased Donor Transplants at a High Volume Center
R. Rajalingam,¹ D. Gae,¹ Z. Laszik,² G. Roll,³ M. Tavakol,³ C. Freise,³ D. Adey,⁴ A. Webber,⁴ D. Dobi,² K. Cunniffe,¹ G. da Gente,¹ N. Ascher,³ P. Stock,³ J. Roberts.³
¹Immunogenetics and Transplantation Laboratory, Dept. of Surgery, UCSF, San Francisco; ²Dept. of Pathology, UCSF, San Francisco; ³Dept. of Surgery, UCSF, San Francisco; ⁴Dept. of Medicine, UCSF, San Francisco.
Aim: We developed a reliable virtual crossmatch (VXM) method for use as pre-transplant XM for deceased donor (DD) kidney transplantation (KTx). Here we report the…
2018 American Transplant Congress
Evolution of Very Old Donor Grafts
S. Jiménez Alvaro,¹ A. Fernández Rodriguez,¹ C. Galeano Alvarez,¹ S. Elías Treviño,¹ J. Burgos,² F. Liaño García.¹
¹Nephrology, Hospital Ramón y Cajal, Madrid, Spain; ²Nephrology, Hospital Ramón y Cajal, Madrid, Spain; ³Nephrology, Hospital Ramón y Cajal, Madrid, Spain; ⁴Nephrology, Hospital Ramón y Cajal, Madrid, Spain; ⁵Urology, Hospital Ramón y Cajal, Madrid, Spain; ⁶Nephrology, Hospital Ramón y Cajal, Madrid, Spain.
Introduction: The need to implement the pool of donors has led to the use of organs from older donors, as has been described in several…
2018 American Transplant Congress
Pharmacogenetics of CYP3A4, CYP3A5, CYP2C8 and CYP2C19 and Their Influence on Tacrolimus Pharmacokinetics in Renal Transplant Recipients
Z. Wang, Z. Han, J. Tao, H. Chen, L. Sun, R. Tan, M. Gu.
Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China.
Tacrolimus (TAC) is an established essential immunosuppressive agent for renal transplant recipients. Our study aims to investigate the pharmacogenetics of CYP3A4, CYP3A5, CYP2C8 and CYP2C19…
2018 American Transplant Congress
Once-Daily versus Twice-Daily Tacrolimus in De Novo Living Kidney Transplantation Patients: A Multicenter, Parallel Group, Open-Label, 5-Year Randomized Noninferiority Trial
Y. Kakuta,¹ M. Okumi,¹ K. Unagami,² M. Furusawa,¹ H. Ishida,¹ K. Tanabe.¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Nephrology, Tokyo Women's Medical University, Tokyo, Japan.
BackgroundTacrolimus is available as twice-daily (TAC-BID) and once-daily (TAC-QD) formulations. Findings from pharmacokinetic and short-term trials are available. However, results from long-term trials are limited.We…