Am J Transplant, Volume 18, Suppl 3 Archives - Page 38 of 211 - ATC Abstracts

2018 American Transplant Congress
Pancreas Transplant for Type 2 Diabetes is Associated with Preserved Function, but Impaired Glucose Tolerance: A Comparative Analysis
S. Doshi, C. Pulitano, D. Al-Adra, A. Norgate, G. Sapisochin, M. Selzner, I. McGilvray, J. Schiff, M. Cattral.
Multi-Organ Transplant Program, Toronto General Hospital, Toronto, ON, Canada.
Background: The indications and outcomes of pancreas transplantation for type 2 diabetes mellitus (T2DM) remains controversial. The aim of this study was to compare the…
2018 American Transplant Congress
Hypoxia Results in Endoplasmic Reticulum Stress and Activation of the Unfolded Protein Response in Isolated Human Islets and Human Donor Pancreases
B. Sandhu, M. Prendecki, N. Vallant, G. Rutter, C. Pusey, V. Papalois.
Imperial College London, London, United Kingdom.
Background: The Unfolded Protein Response (UPR) is activated as an adaptive response to endoplasmic reticulum (ER) stress, however if ER stress is not resolved, UPR…
2018 American Transplant Congress
Resident Perceptions and Evaluations of a Fellow-Led Transplant Service versus Resident-Led Surgical Services
A. Williams, M. Barrett, N. Matusko, S. Dennahy, R. Sung, G. Sandhu, K. Woodside.
Department of Surgery, University of Michigan, Ann Arbor, MI.
Background: Transplant rotations as a core requirement for surgical training have been questioned. However, surgical resident perceptions of a fellow-led transplant service have not been…
2018 American Transplant Congress
Tomotherapy and Donor Hematopoietic Cells for Tolerance to Kidney Transplants in Rhesus Macaques
D. Kaufman,¹ L. Haynes,¹ P. Hematti,¹ W. Burlingham,¹ L. Forest,² J. Post,¹ R. Redfield,¹ L. Fernandez,¹ A. D'Alessandro,¹ J. Haynes,¹ K. Jensen,³ S. Strober.³
¹Surgery, University of Wisconsin School of Medicine, Madison, WI; ²Surgical Sciences, University of Wisconsin School of Vet Med, Madison, WI; ³Medicine, Stanford University Medical School, Palo Alto, CA.
The goal of this project was to develop a tolerance induction protocol for MHC 1-haplotype mismatched kidney transplants (txs) in a rhesus macaque model. The…
2018 American Transplant Congress
Long Noncoding RNA NEAT1 Induces Tolerogenic Dendritic Cells in Heart Transplantation
J. Wu,^1,2 Y. Zheng,^1,2 S. Li,^1,2 M. Zhang,^1,2 H. Zhang,^1,2 X. Zheng,^1,2 Y. Sun,^1,2 B. Yu.^1,2
¹Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China; ²The Key Laboratory of Myocardial Ischemia, Harbin Medical University, Ministry of Education, Harbin, Heilongjiang, China.
Purpose: Tolerogenic dendritic cells have been gaining interest as an efficient means of promoting antigen-specific tolerance in organ transplantation. Long noncoding RNA NEAT1 plays an…
2018 American Transplant Congress
Anti-Thymocyte Globulin Directly Binds and Functionally Inhibits Allo-Regulatory Myeloid Derived Suppressor Cells
Y. Lee, E. Davila, J. Bromberg, J. Scalea.
Surgery and Immunology, University of Maryland, Baltimore, MD.
BACKGROUND: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of naturally occurring, immunosuppressive cells that may be exploitable in transplantation.There are only a few incomplete…
2018 American Transplant Congress
p40 Homodimer Induced Proliferation of Endogenous Donor-Reactive Memory CD8 T Cells within High Risk Allografts Requires Memory CD8 T Cell Expression of CD122
H. Tsuda, A. Valujskikh, R. Fairchild.
Immunology, Cleveland Clinic, Cleveland, OH.
Increasing the duration of cold ischemic storage (CIS) from 0.5 to 8 hrs prior to transplant induces the increased proliferation of endogenous donor-reactive CD4 and…
2018 American Transplant Congress
A Novel Endothelial Cell Based Complement Dependent Cytotoxicity Test in Kidney Transplantation
R. Lammerts,¹ J. van den Born,¹ W. Dam,¹ M. Seelen,¹ B. Hepkema,² B. Kroesen,² M. Daha,¹ R. Pol,³ S. Berger,¹ On behalf of the COMBAT Consortium.¹
¹Department of Nephrology, University Medical Centre Groningen, Groningen, Netherlands; ²Department of Immunology, University Medical Centre Groningen, Groningen, Netherlands; ³Department of Surgery, University Medical Centre Groningen, Groningen, Netherlands.
Introduction:Relevant alloantibodies in kidney transplantation comprise anti-HLA antibodies, blood group antibodies (ABO incompatible) and anti-endothelial cell antibodies (AECA) and can initiate antibody-mediated rejection (ABMR). ABMR…
2018 American Transplant Congress
Single vs. Multi-Drug Antibiotic Prophylaxis for Continuous-Flow Left Ventricular Assist Device Implantation: A Systematic Review and Meta-Analysis
S. Patel,¹ J. Choi,¹ E. Moncho Escrivà,² S. Rizvi,¹ L. Samuels,¹ J. Luc,³ R. Morris,¹ H. Massey,¹ V. Tchantchaleishvili,¹ N. Aburjania.⁴
¹Division of Cardiac Surgery, Thomas Jefferson University, Philadelphia, PA; ²University of Granada, Granada, Spain; ³University of Alberta, Edmonton, AB, Canada; ⁴Division of Infectious Diseases, Thomas Jefferson University, Philadelphia, PA.
Purpose: Despite the fact that infection remains a major complication of continuous-flow left ventricular assist device (CF-LVAD) therapy, an optimal antimicrobial surgical infection prophylaxis (SIP)…
2018 American Transplant Congress
Cardiac MRI May Help to Determine When to Refer Heart Transplant Patients for Redo Heart Transplant
M. Kittleson, J. Patel, E. Kransdorf, S. Dimbil, R. Levine, D. Geft, D. Chang, L. Czer, J. Kobashigawa.
Cedars Sinai Medical Center, Los Angeles.
Purpose: Small vessel coronary artery disease is known to cause fibrosis. However, it is not clear whether myocardial fibrosis detected on MRI is associated with…