Am J Transplant, Volume 18, Suppl 3 Archives - Page 32 of 211 - ATC Abstracts

2018 American Transplant Congress
Outcomes of Donation after Cardiac Death Liver Grafts from Donors ≥ 50 Years of Age: A Multi-Center Analysis
K. P. Croome,¹ A. K. Mathur,³ D. D. Lee,¹ A. A. Moss,³ C. B. Rosen,² J. K. Heimbach,² C. B. Taner.¹
¹Mayo Clinic Florida, Jacksonville, FL; ²Mayo Clinic Rochester, Rochester, MN; ³Mayo Clinic Arizona, Scottsdale, AZ.
Introduction:As the population in the United States continues to age, an increase in the number of potential DCD donors with advanced chronological age can be…
2018 American Transplant Congress
De Novo Belatacept in Clinical Vascularized Composite Allotransplantation
L. C. Cendales,¹ D. S. Ruch,² A. R. Cardones,³ G. Potter,⁴ J. Dooley,⁵ D. Dore,⁶ J. Orr,¹ G. Ruskin,⁶ M. Song,¹ D. Chen,⁷ A. Selim,⁷ A. D. Kirk.¹
¹Surgery, Duke University, Durham, NC; ²Orthopedics, Duke University, Durham, NC; ³Dermatology, Duke University, Durham, NC; ⁴Psychiatry and Behavioral Sciences, Duke University, Durham, NC; ⁵Anesthesiology, Duke University, Durham, NC; ⁶Psysical and Occupational Therapy, Duke University, Durham, NC; ⁷Pathology, Duke University, Durham, NC.
Most immunosuppressive regimens in vascularized composite allotransplantation (VCA) have been calcineurin inhibitor (CNI)–based. Costimulation blockade has emerged as a replacement for CNI–based regimens in kidney…
2018 American Transplant Congress
Depletion Resistant Effector Memory T Cells Mediate Thymoglobulin Refractory Allograft Rejection in Human Intestinal Transplant Recipients
O. Aguirre, B. Houlihan, A. Karabala, C. Cosentino, R. Girlanda, J. Hawksworth, C. Matsumoto, M. Zasloff, T. Fishbein, A. Kroemer.
Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC.
A. This study aimed to determine the mechanisms underlying T cell depletion-resistant moderate to severe acute cellular rejection (ACR) in intestinal transplantation (ITx) patients.B. A…
2018 American Transplant Congress
Ischemia Reperfusion Injury & Risk for Antibody Mediated Rejection (ABMR) in HLA Sensitized Patients Treated with C1 Esterase Inhibitor (C1INH)
A. Vo,¹ O. Aubert,² J. Choi,¹ N. Ammerman,¹ H. Edmund,¹ A. Peng,¹ R. Najjar,¹ S. Supreet,¹ S. Jordan.¹
¹Kidney Transplant, Cedars-Sinai Medical Center, LA, CA; ²Paris Translational Research for Organ Transplantation, Necker Hospital, Paris, France.
Introduction: Ischemia reperfusion injury (IRI) contributes to delayed graft function (DGF). IRI/DGF in HLA-sensitized (HS) patients likely activates innate and memory injury pathways that may…
2018 American Transplant Congress
Effect of Everolimus with Reduced Calcineurin Inhibitor on Efficacy and Safety in De Novo Kidney Transplant Recipients: 12-Month Results from the US Cohort of TRANSFORM Study
S. Mulgaonkar,¹ Y. Qazi,¹ D. Kim,¹ V. Peddi,¹ K. McCague,² D. Patel,² A. Wiseman.¹
¹TRANSFORM Study Group, Livingston; ²Novartis Pharmaceuticals Corporation, East Hanover.
Purpose: Despite remarkable short-term survival benefits, long-term outcomes in kidney transplant recipients (KTRs) remain unsatisfactory. Everolimus (EVR) may improve long-term outcomes by reducing calcineurin inhibitor…
2018 American Transplant Congress
The Impact of Age-Matching on Graft Function and Graft Survival after Living Donor Kidney Transplantation
J. Lee,¹ D. Kim,¹ J. Lee,¹ J. Lee,¹ Y. Jung,¹ M. Ju,¹ S. Song,² J. Lee,³ K. Huh,¹ B. Kim,⁴ S. Kim,¹ Y. Kim,¹ M. Kim.¹
¹Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea; ²Department of Surgery, Ewha Womans University, School of Medicine, Seoul, Republic of Korea; ³Department of Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea; ⁴Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
Introduction: To overcome the shortage of organs, the influence of age matching in living donor kidney transplantation should be studied. We analyzed the impact of…
2018 American Transplant Congress
Steroid Sparing Maintenance Immunosuppression is Associated with Decreased Mortality after Simultaneous Liver Kidney Transplantation
S. Weeks, X. Luo, C. Song, L. Pote, A. Gurakar, F. Navqi, B. Philosophe, A. Cameron, N. Desai, S. Ottmann, D. Segev, J. Garonzik Wang.
Johns Hopkins, Baltimore, MD.
Purpose: Significant variation in maintenance immunosuppression (mIS) regimens has been described between transplant centers for simultaneous liver kidney (SLK) transplant recipients; we sought to describe…
2018 American Transplant Congress
The Protective Effect of Multivisceral Transplantation on Intestinal Allograft Rejection – Its Correlation with T-Cell Macrochimerism from a Long-Term Prospective Study
P. Liou,¹ M. Martinez,¹ J. Fu,² M. Velasco,¹ A. Griesemer,¹ S. Lobritto,¹ J. Vittorio,¹ S. Ravella,¹ B. Levin,³ J. Emond,¹ M. Sykes,² T. Kato.¹
¹Center for Liver Disease and Transplantation, Columbia University, New York, NY; ²Columbia Center for Translational Immunology, Columbia University, New York, NY; ³Department of Biostatistics, Columbia University, New York, NY.
Objective Graft rejection remains the crux of intestinal transplantation. Although liver-inclusive grafts appear to be protective, the mechanism remains unknown. We hypothesize that T-cell macrochimerism…
2018 American Transplant Congress
Senolytic Drug Treatment Attenuates mtDNA-Mediated Inflammatory Injury in Old Donors and Prolongs Cardiac Allograft Survival
K. Minami,¹ M. Seyda,¹ T. Heinbokel,¹ Y. Nian,¹ M. Quante,¹ G. Liu,¹ R. Abdi,² T. Tchkonia,³ J. Kirkland,³ A. Elkhal,¹ S. Tullius.¹
¹Transplant Surgery Division, Department of Surgery, Brigham and Women's Hospital, Boston, MA; ²Transplantation Research Center, Brigham and Women's Hospital, Boston; ³Robert and Arlene Kogod Center on Aging, Mayo Clinic College of Medicine, Rochester, MN.
Introduction: Solid organ transplantation has seen a increase in the utilization of older organs. Here, we investigate how aging-associated kinetics of damage associated molecular patterns…
2018 American Transplant Congress
Outcomes Analysis of Liver Transplantation Combined with Neoadjuvant Therapy in Patients with Unresectable Locally-Advanced Cholangiocarcinoma
M. Wong,¹ J. Kim,¹ C. Eriksen,¹ T. Pearson,¹ J. Robbins,² B. George,³ M. Zimmerman,¹ J. Hong.¹
¹Div. of Transplant Surgery, Medical College of Wisconsin and Froedtert Hospital (MCW & FH), Milwaukee, WI; ²Dept. of Radiation Oncology, MCW & FH, Milwaukee, WI; ³Div. of Hematology/Oncology, MCW & FH, Milwaukee, WI.
Objective: Liver transplantation (LT) combined with neoadjuvant chemoradiation (NCR) in well-selected patients with unresectable cholangiocarcinoma (CCA) achieves excellent long-term recurrence-free survival. Current criteria for NCR-LT…