Am J Transplant, Volume 18, Suppl 3 Archives - Page 32 of 211 - ATC Abstracts

2018 American Transplant Congress
M-CSF and TNF-α Induce Human MDSCs That Attenuate GVHD
F. Han, C. Ding, Y. Zhao, P. Tian.
Department of Kidney Transplantation, Hospital of Nephropathy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Myeloid-derived suppressor cells (MDSCs) negatively regulate immune response and participate in the induction of prolonged allograft survival in animal models. Human MDSC therapy may be…
2018 American Transplant Congress
Effect of Erythropoietin on Cardiac Allograft Survival in Non-Human Primates
J. O.,¹ K. Robinson,¹ W. Sommer,¹ K. Pruner,¹ J. Paster,¹ M. Hanekamp,¹ A. Dehnadi,¹ I. Rosales,¹ R. Smith,¹ P. Cravedi,² P. Heeger,² G. Benichou,¹ J. Madsen.¹
¹MGH, Boston; ²Icahn School of Medicine at Mount Sinai, New York.
Purpose: Tolerance of cardiac allografts has been achieved in cynomolgus monkeys for the first time via mixed hematopoietic chimerism and donor kidney co-transplantation, but the…
2018 American Transplant Congress
Post-Hoc Analysis of Everolimus Trough Levels around the Onset of Related Adverse Events and Treatment Discontinuation in De Novo Kidney Transplant Recipients from the US92 Study
F. Shihab,¹ Y. Qazi,¹ V. Peddi,¹ D. Shaffer,¹ K. McCague,² D. Patel,² S. Mulgaonkar.¹
¹US92 Study Group, Salt Lake City; ²Novartis Pharmaceutical Corporation, East Hanover.
Purpose: Around 30%-50% of kidney transplant recipients (KTR) on sirolimus discontinue treatment due to drug-related adverse events (AE) and ~23% on everolimus (EVR) discontinue treatment…
2018 American Transplant Congress
Comparison of Continuous Normothermic Ex Vivo Kidney Perfusion to Hypothermic Preservation Methods in Pig Kidneys Donated after Cardiac Death
M. Hamar,^1,2 P. Urbanellis,¹ D. Kollmann,¹ I. Linares,¹ M. Kaths,¹ D. Bagli,³ A. Konvalinka,⁴ I. Mucsi,¹ A. Ghanekar,¹ L. Robinson,² M. Selzner.¹
¹Multi Organ Transplant Program, TGH, Toronto, ON, Canada; ²Division of Nephrology, The Hospital of Sick Children, Toronto, ON, Canada; ³Dept. of Surgery (Urology) & Physiology, The Hospital of Sick Children, Toronto, ON, Canada; ⁴Dept. of Medicine and Institute of Medical Science, UHN and Univ. of Toronto, Toronto, ON, Canada.
Background: Strategies to decrease preservation-related injury in renal grafts donated after circulatory death urgently needed. This highlights the importance of direct comparison of dynamic preservation…
2018 American Transplant Congress
The Continuous Debate of Older Donors into Older Recipients: Another Angle
J. Patel, M. Kittleson, E. Kransdorf, S. Dimbil, R. Levine, D. Geft, D. Chang, L. Czer, J. Kobashigawa.
Cedars Sinai Medical Center, Los Angeles.
Purpose: Heart transplantation (HTx) remains limited by donor availability. Many programs accept older donors (≥50 yrs) for older recipients (≥ 60 yrs) in an effort…
2018 American Transplant Congress
Outcomes of Subsequent Pregnancies in Female Heart Transplant Recipients
S. Rao,^1,2 D. Armenti,¹ L. Coscia,¹ S. Constantinescu,^1,2 M. Moritz.^1,3,4
¹Transplant Pregnancy Registry International, Gift of Life Institute, Philadelphia, PA; ²Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA; ³Surgery, Lehigh Valley Health Network, Allentown, PA; ⁴Surgery, Morsani College of Medicine, Tampa, FL.
The purpose of this study is to analyze the maternal and newborn outcomes in successive pregnancies in female heart transplant recipients (HT) reported to the…
2018 American Transplant Congress
Incidence of Pneumonitis in Heart Transplant Patients Started on a Proliferation Signal Inhibitor
R. Levine, J. Patel, M. Levine, M. Kittleson, E. Kransdorf, S. Dimbil, D. Geft, D. Chang, L. Czer, J. Kobashigawa.
Cedars Sinai Medical Center, Los Angeles.
Purpose: Proliferation signal inhibitors(PSI) have a high discontinuation rate due to side effects. PSI induced pneumonitis has been reported in 14% in renal cell carcinoma…
2018 American Transplant Congress
Ex-Vivo Pretreatment of Islets with Mitomycin-C Have a Potential to Induce Specific Immune Response for Peripheral Tolerance
N. Sato, A. Kenjo, T. Kimura, R. Okada, T. Ishigame, Y. Kofunato, J. Watanabe, M. Muto, S. Suzushino, T. Shimura, S. Marubashi.
Hepato-Biliary-Pancreatic and Transplant Sugery, Fukushima Medical University, Fukushima, Japan.
Background.Our previous study demonstrated that ex-vivo Mitomycin-C(MMC) pretreatment of islets reduced immunogenicity, enhancing graft survival without immunosuppression(IS). However, it is still unclear whether donor specific…
2018 American Transplant Congress
Transplant Benefit to Patients with Long Dialysis Vintage
A. Massie, D. Crews, T. Purnell, J. Garonzik-Wang, D. Segev.
Johns Hopkins, Baltimore.
Following implementation of KAS, deceased donor kidney transplant (DDKT) waitlist registrants with long dialysis vintage have high allocation priority. However, having survived for many years…
2018 American Transplant Congress
Should Kidneys from Donation after Cardiac Death Expanded Criteria Donors Be Transplanted?
D. Harriman, J. Rogers, A. Farney, G. Orlando, A. Reeves-Daniel, M. Gautreaux, W. Doares, S. Kaczmorski, R. Stratta.
Surgery, Medicine, Pathology, Pharmacy, Wake Forest Baptist Medical Center, Winston-Salem, NC.
Introduction: Expanded criteria donor (ECD) kidneys increase the organ pool but their discard rate remains high, especially in the setting of donation after cardiac death…