2018 American Transplant Congress
Pancreas Transplant in the Elderly Patient – Should It Be Done?
1SUNY Downstate Medical Center, Brooklyn, NY; 2SUNY Upstate Medical University, Syracuse, NY.
Introduction: While kidney transplantation in the elderly diabetic patient is an accepted treatment of the secondary complication, pancreas transplants are controversial. Many centers have an…2018 American Transplant Congress
Ablation of IRF4 Induces Transplant Tolerance by Driving Intrinsic T Cell Dysfunction
How transplant rejection is regulated on a transcriptional level remains unclear. We found that T cell-specific conditional knockout (cKO) of the transcription factor IRF4 in…2018 American Transplant Congress
Pro-Inflammatory B Cells Predict Progressive Minimal Early Renal Allograft Inflammation Which is Associated with Poor Graft Outcomes
The clinical significance of minimal tubulointerstitial inflammation (MTI:'t'+'i'scores 0.5-1.5) and Banff Borderline changes (BBC:'t'+'i'scores 2-3) in early renal allograft biopsies is unclear. The rate and…2018 American Transplant Congress
Parsing the 100% CPRA Kidney Transplant Candidates, Who Gets Transplanted?
Medicine, Sacred Heart Hospital, Pensacola, FL.
Currently the United States kidney allocation system gives priority to candidates with a CPRA of 100% by giving them additional allocation points and providing national…2018 American Transplant Congress
Cell Free DNA Sequencing for Diagnosing Infections, Estimating Growth Rates, and Characterizing Antibiotic Resistomes in Urine Supernatants
1Weill Cornell Medicine, New York, NY; 2Cornell University, Ithaca, NY.
INTRODUCTION. We examined the utility of cell-free DNA (cfDNA) sequencing of urine supernatants in kidney transplant recipients for diagnosing rare and common urinary tract infections…2018 American Transplant Congress
Early Microcirculation Inflammation Associated with TCMR Leads to Poor Graft Outcomes in Kidney Transplant Recipients (KTRs)
Renal allograft microcirculation inflammation (MI) lesions including glomerulitis (g) and peritubular capillaritis (ptc) are associated with AMR and poor outcomes. The significance of MI lesions…2018 American Transplant Congress
Liver Transplantation Using Pediatric versus Adult Donor Grafts in Adult Recipients
Organ Transplant Center, Sun Yat-sen University, Guangzhou, Guangdong, China.
Background and Aim: The reported outcomes of adult liver transplantation using pediatric allografts are largely controversial based on single center studies. We aimed to compare…2018 American Transplant Congress
CD4 T Cells Require Both S1PR1 and S1PR4 for Afferent Lymphatic Migration
1UMB, MD; 2NIH, MD; 3Boston Children's Hospital, MA; 4NYU, NY; 5U. Minnesota, MN.
Introduction: Sphingosine 1-phospate (S1P) receptor 1 (S1PR1) drives T cell migration from thymus into blood, and lymph nodes (LN) into efferent lymphatics. Whether S1PR1 and…2018 American Transplant Congress
Ex Vivo-Expanded Human CD19+CD73–CD25+CD71+TIM-1+ B Regulatory Cells Can Prolong Allograft Survival in a Humanized Mouse Model of Skin Transplantation and Are Dependent on TIM-1-Mediated Regulation of STAT3 Signaling
The importance of B regulatory cells (Breg) in both health and disease has rapidly become evident over the last decade. Breg are able to control…2018 American Transplant Congress
Outcome of Second Kidney Transplantation According to Previous Pediatric Donor Type: A Retrospective Cohort Analysis
Medicine-Nephrology, UCLA, Los Angeles, CA.
Background: With the prioritization of age ≤ 18 years old at the time of registration on the kidney transplant waiting list in the United States,…
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