Am J Transplant, Volume 18, Suppl 3 Archives - Page 27 of 211 - ATC Abstracts

2018 American Transplant Congress
Increase in Potentially Resistant Non-Aspergillus Molds Isolated in Lung Transplant Recipients after Voriconazole and Posaconazole Prophylaxis
M. Fung,¹ J. Greenland,^2,3 S. Hays,² J. Singer,² J. Golden,² P. Chin-Hong.¹
¹Infectious Diseases, University of California San Francisco, San Francisco, CA; ²Pulmonary and Critical Care, University of California San Francisco, San Francisco, CA.
Background: Lung transplant recipients are at higher risk for invasive fungal infections compared to other solid organs transplant patients. Antifungal prophylaxis with mold-active azoles has…
2018 American Transplant Congress
Genetically Modified Porcine Erythrocytes: A Cell Model for Studying Human Preformed Antibody-Dependent Xenoimmune Responses In Vitro
Z. Wang, G. Martens, J. Ladowski, M. Tector, A. Tector.
Surgery, University of Alabama at Birmingham, Birmingham, AL.
Background: Powerful gene editing technology is a promising approach to provide genetically-modified pigs as donors for clinical cell, tissue and organ xenotransplantation. Prior to starting…
2018 American Transplant Congress
Transplanting Kidneys from HCV-Infected Donors into HCV-Negative Recipients: Longer-Term and Extended Results of the THINKER Trial
D. Goldberg,¹ E. Blumberg,¹ P. Abt,¹ M. Levine,¹ P. Porrett,¹ A. Naji,¹ S. Nazarian,¹ D. Sawinski,¹ J. Trofe-Clark,¹ V. Van Deerlin,¹ C. Gentile,¹ J. Smith,¹ M. Kaminski,¹ A. Sicilia,¹ R. Hasz,² L. Suplee,² R. Reddy,¹ R. Bloom,¹ P. Reese.¹
¹University of Pennsylvania, Philadelphia; ²Gift of Life, Philadelphia.
Background: In 2016, 800 kidneys from HCV+ deceased donors were discarded. Short-term (6-month) data from the first 10 subjects in the THINKER-1 trial (NCT02743897; funder:…
2018 American Transplant Congress
Outcome Implications of Benzodiazepines and Opioid Co-Prescriptions before Kidney Transplantation
N. Lam,¹ M. Schnitzler,² D. Axelrod,³ V. Dharnidharka,⁴ D. Segev,⁵ A. Naik,⁶ H. Xiao,² R. Ouseph,² H. Randall,² G. Hess,⁷ B. Kasiske,⁸ D. Brennan,⁵ T. Alhamad,⁴ K. Lentine.²
¹Univ Alberta, Edmonton, Canada; ²Saint Louis Univ, St. Louis; ³Lahey Clinic, Burlington; ⁴Washington Univ, St. Louis; ⁵Johns Hopkins, Baltimore; ⁶Univ Michigan, Ann Arbor; ⁷Hennepin, Minneapolis; ⁸Symphony Health, Conshohocken.
Recent studies have identified co-prescription of benzodiazepines and opioids as a risk factor for adverse outcomes in the general population. We previously described associations of…
2018 American Transplant Congress
Secular Trends in the Medical Complexity and Outcomes of Medicare-Insured Patients Undergoing Kidney Transplant
C. Lenihan,¹ S. Liu,¹ M. Montez-Rath,¹ W. Winkelmayer.²
¹Stanford University, Palo Alto, CA; ²Baylor College of Medicine, Houston, TX.
Graft and patient survival following kidney transplant (KT) are improving. The reasons for this trend are unclear. We set out to examine concurrent changes in…
2018 American Transplant Congress
Anti-TIRC7 Antibody Acts Synergistically with Tacrolimus in Promoting Graft Survival in a Rat Kidney Transplant Model
S. Tullius,¹ Y. Kumamoto,² U. Nalan.³
¹Department of Medicine, Brigham and Women's Hospital, Boston, MA; ²Department of Surgery, Kitasato University School of Medicine, Kanagawa, Sagamihara, Japan; ³Institute for Medical Immunology, University Hospital Charite, Berlin, Germany.
Background: Induction of T cell immune response c-DNA (TIRC7) is restricted to activated lymphocytes. Modulation of TIRC7 signalling prevents immune activation specifically at the site…
2018 American Transplant Congress
Outcomes after HIV+ Kidney Transplant: A HOPE in Action Study
C. Durand,¹ M. Bowring,¹ A. Tobian,¹ D. Brown,¹ N. Desai,¹ S. Bagnasco,¹ D. Ostrander,¹ A. Redd,¹ S. Huprikar,² B. Haydel,² S. Lerner,² S. Florman,² S. Chandran,³ A. Chao,³ J. Locke,⁴ S. Mehta,⁴ R. Freidman,⁵ N. Turgeon,⁵ A. Massie,¹ D. Segev.¹
¹JHU, Baltimore, MD; ²Mount Sinai, New York, NY; ³UCSF, San Francisco, CA; ⁴UAB, Birmingham; ⁵Emory, Atlanta.
The HIV Organ Policy Equity (HOPE) Act allows HIV-infected donor (HIV D+) organs to be transplanted into HIV+ recipients (HIV R+) under research protocols. We…
2018 American Transplant Congress
Extra-Renal Effects of Estrogen Receptor-Alpha Mediate Protection from Renal Ischemia-Reperfusion Injury
D. Aufhauser, D. Murken,¹ S. Concors,¹ Z. Wang,¹ G. Ge,¹ T. Bhatti,² W. Hancock,^2,3 M. Levine.¹
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Pathology, Children's Hospital of Philadelphia, Philadelphia, PA; ³Pathology, University of Pennsylvania, Philadelphia, PA.
Introduction: Females exhibit protection from renal ischemia-reperfusion injury (IRI) compared to males in animal models and in human kidneys transplants. Previous experiments have shown that…
2018 American Transplant Congress
Class II Anti-HLA IgG2 and IgG3 DSAs Predict Poorer Outcomes in Chronic Antibody Mediated Rejection of Renal Allografts
A. Gueret-Wardle,¹ G. Lucisano,¹ S. Hassan,¹ P. Brookes,² E. Santos-Nunez,² D. Goodall,¹ C. Clarke,¹ J. Galliford,¹ M. Willicombe,¹ D. Taube.¹
¹Renal and Transplant Centre, Imperial College London NHS Trust, London, United Kingdom; ²Histocompatibility and Immunogenetics, Imperial College London, London, United Kingdom.
Introduction: whilst the development of IgG3 and C1q binding de novo [dn] HLA DSAs are associated with a poor outcome in acute antibody mediated rejection,…
2018 American Transplant Congress
Effects of a Multimodal Pain Control Regimen in Living Donor Laparoscopic Nephrectomies
E. Thomas, J. Nelson, E. Diaz.
Department of Surgery, University of Florida, Gainesville, FL.
Purpose: Evaluate the effects of a multimodal pain control regimen on length of stay (LOS), opioid consumption, pain control, and opioid/NSAID related adverse events in…