ATC Abstracts

American Transplant Congress abstracts

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  • 2018 American Transplant Congress

    Follow-Up and Outcomes of Epstein-Barr Virus Negative Recipients after a Kidney Transplant from an Epstein-Barr Virus Positive Donor

    C. Dudreuilh, E. Asgari, R. Hilton.

    Departments of Nephrology and Transplantation, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.

    Introduction: Post-transplant lymphoproliferative disorder (PTLD) is one of the most serious complications of chronic immunosuppression after an organ transplant. One of the major risk factors…
  • 2018 American Transplant Congress

    Functional Reconstruction of Urogenital Tissue Defects Using VCA: A Novel Microsurgical Penis Transplant Model and Clinical & Histological Rejection Classification

    S. Fidder,1,4 G. Furtmüller,1 B. Simons,2 B. Kern,1 D. Lough,1 B. Oh,1 M. Chicco,1 C. Brayton,3 W. Lee,1 D. Cooney,1 R. Redett,1 G. Brandacher.1

    1Dept of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore; 2Dept of Urology, JHU SOM, Baltimore; 3Dept of Molecular & Comparative Pathobiology, JHU SOM, Baltimore; 4Plastic and Reconstructive Surgery, Erasmus University Medical Center, Rotterdam, Netherlands.

    Background: Defects of male urogenital structures subsequent to major trauma are associated with severely reduced function and quality-of-life. As of recent, penis transplantation represents an…
  • 2018 American Transplant Congress

    Dual Function of IRF1/IRF4 on Dendritic Cells in Mouse Liver Transplantation Model

    G. Gu, T. Lu, N. Xu, Q. Xia.

    Department of Liver Surgery, Renji Hospital, Affiliated by Shanghai Jiaotong University School of Medicine, Shanghai, China.

    Tolerogenic dendritic cells play an essential role in transplant tolerance induction. However, how to induce tolerogenic dendritic cells is not fully understood. Here, we sorted…
  • 2018 American Transplant Congress

    Scoring Transplant Glomerulopathy Using Morphometry: Correlation with Banff Criteria

    M. Morales, A. Denic, W. Park, B. Smith, M. Alexander, M. Stegall.

    William J.von Liebig Transplant Center, Mayo Clinic, Rochester, MN.

    Background: Transplant glomerulopathy (TG) is a prognostic marker for graft survival. Still, scoring TG using the Banff cg-score remains a challenge and no assessments in…
  • 2018 American Transplant Congress

    Liver Transplant Recipients with End-Stage Renal Disease Largely Benefit from Kidney Transplantation

    W. Ju, Y. Tang, Q. Zhao, L. Jing, S. Huang, Z. Zhu, F. Ji, Z. Zhang, X. He, G. Chen, Z. Guo, D. Wang.

    Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

    Background: The incidence of end-stage renal disease (ESRD) following liver transplant (LT) has increased. The actual benefit of kidney transplantation (KT) is not completely understood…
  • 2018 American Transplant Congress

    Impact of Elderly Donor Obesity on Long-Term Outcomes in Renal Transplant Recipients

    M. Yamada,1 R. Jandarov,2 T. Kaur,1 S. Shah.1

    1Nephrology, University of Cincinnati, Cincinnati, OH; 2Environmental Health, University of Cincinnati, Cincinnati, OH.

    Background: There has been a dramatic increase in obesity in the United States. Due to longer waiting times, utilization of kidneys from older donors has…
  • 2018 American Transplant Congress

    Validation of Genetic Variants Identified in GWAS for Tacrolimus Troughs

    P. Jacobson,1 D. Schladt,2 W. Guan,3 J. van Setten,6 R. Remmel,4 B. Wu,3 C. Dorr,5 B. Keating,7 D. Ikle,9 R. Mannon,10 A. Matas,8 A. Israni,5 W. Oetting.1

    1Experimental and Clinical Pharmacology, Univ of MN, Minneapolis, MN; 2Chronic Disease Research Group, Minneapolis Medical Research Foundation, Hennepin County Medical Center, Minneapolis, MN; 3Division of Biostatistics, Univ of MN, Minneapolis, MN; 4Medicinal Chemistry, Univ of MN, Minneapolis, MN; 5Medicine, Hennepin County Medical Center, Minneapolis, MN; 6Cardiology, University Medical Center Utrecht, Utrecht, Netherlands; 7Surgery, Univ of Pennsylvania, Philadelphia, PA; 8Surgery, Univ of MN, Minneapolis, MN; 9Rho Inc, Chapel Hill, NC; 10Department of Medicine and Surgery, Univ of Alabama, Birmingham, AL.

    Purpose: Tacrolimus (TAC) is a substrate for CYP3A4/5 enzymes. It is well-known that variants in these genes are associated with variability in TAC trough concentrations.…
  • 2018 American Transplant Congress

    Belatacept and Tacrolimus Corticosteroid-Free Regimens Lead to Elevated Mycophenolic Acid Exposure at 1 and 3 Months after Kidney Transplantation

    A. Dao, S. Tremblay, A. Shields, A. Loethen, B. Abu Jawdeh, T. Diwan, A. Govil, E. Woodle, R. Alloway.

    UCincinnati, Cincinnati.

    Mycophenolate mofetil (MMF) is generally administered as a fixed dose. Studies have shown a relationship between MPA exposure (MPAAUC) but no data evaluates this relationship…
  • 2018 American Transplant Congress

    Immunosuppression Does Not Affect Adverse Pathological Outcomes in Men Who Underwent Radical Prostatectomy

    M. Eltemamy, A. Elshafei, Y. Nyame, A. Crane, A. Wee, V. Krishnamurthi, E. Klein, S. Jones.

    Cleveland Clinic, Cleveland.

    Introduction: The impact of imuunosuppression (IS) on biological aggressiveness of cancer prostate (PCa) is unclear. We aim to assess the adverse pathological (AP) outcomes in…
  • 2018 American Transplant Congress

    Racial/Ethnic Disparities in Living Donor Kidney Transplantation before and after the New National Kidney Allocation System

    X. Zhang,1 T. Melanson,2 L. Plantinga,3,6 M. Basu,1 S. Pastan,1,7 S. Mohan,4,5 M. Garber,6 R. Patzer.1,6,7

    1Department of Surgery, Emory University School of Medicine, Atlanta; 2Department of Health Policy & Management, Emory University, Atlanta; 3Department of Medicine, Emory University School of Medicine, Atlanta; 4School of Medicine, Columbia University, New York; 5Department of Epidemiology, Columbia University, New York; 6Department of Epidemiology, Emory University, Atlanta; 7Emory Transplant Center, Emory Healthcare, Atlanta.

    We aimed to assess the potential unintended impact of a new national kidney allocation system (KAS) in December 2014 on living donor kidney transplant (LDKT)…
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