Am J Transplant, Volume 18, Suppl 3 Archives - Page 194 of 211 - ATC Abstracts

2018 American Transplant Congress
Demand for Uterine Transplantation in the United States: Initial Recruitment Results of a Trial of Uterine Transplantation in the Northeast U.S.
P. Porrett,¹ N. Latif,² E. Wang,² L. Sortor,³ S. Levin,⁴ A. Shaked,¹ K. Olthoff,¹ C. Coutifaris,² D. Driscoll,² K. O'Neill.²
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²OB/Gyn, University of Pennsylvania, Philadelphia, PA; ³Psychiatry, University of Pennsylvania, Philadelphia, PA; ⁴Orthopedic Surgery, University of Pennsylvania, Philadelphia, PA.
Background Uterine factor infertility (UFI) may affect 7 million women in the United States. Uterine transplantation (UTx) is an emerging treatment for UFI, particularly in…
2018 American Transplant Congress
The Effect of Intravenous Immunoglobulin on In Vitro Human Antibody Binding to Genetically-Engineered Pig Cells – Relevance to Clinical Xenotransplantation –
T. Yamamoto,¹ Q. Li,¹ H. Iwase,¹ D. Ayares,² D. Cooper,¹ H. Hara.¹
¹Xenotransplantation Program, Department of Surgery, University of Alabama at Birmingham, Birmingham; ²Revivicor, Blacksburg.
Background: Xenoreactive antibodies play an important role in xenograft rejection. Intravenous immunoglobulin (IVIG), which has anti-complement activity and contains anti-idiotypic antibodies, is widely used for…
2018 American Transplant Congress
Increased Expression of HLA-DPB1 in Pre-Implantation Kidney Biopsies is Associated with Poor Late Graft Function
K. Mine,¹ T. Mourão,¹ C. Felipe,² G. Rampim,¹ J. Medina-Pestana,² H. Tedesco-Silva,² M. Gerbase-DeLima.¹
¹Instituto de Imunogenética, AFIP, São Paulo, Brazil; ²Hospital do Rim, Universidade Federal de São Paulo, São Paulo, Brazil.
In a previous gene expression microarray study in pre-implantation biopsies (PIB) from kidneys of 53 deceased donors (GeneChip® Human Gene 1.0 ST Arrays, Affymetrix; GEO…
2018 American Transplant Congress
Renal Allograft Cortical Perfusion Quantification by 3D-Arterial Spin Labeling Could Be Used to Identify Subclinical Antibody-Mediated Rejection
W. Wang,¹ J. Wen,² F. Xu,² Y. Yu,³ L. Zhang,³ Z. Liu.²
¹Nanjing Medical University, Jinling School of Medicine, Nanjing, China; ²Jinling Hospital, Nanjing University School of Medicine, National Clinical Research Center of Kidney Diseases, Nanjing, China; ³Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
Background: Antibody-mediated rejection (AMR) is now the most principal post-surgical complication complicating allograft long-term survival. Therefore, its early detection before serum creatinine rises/estimated glomerular filtration…
2018 American Transplant Congress
Psychosocial Assessment of Candidates for Transplantation (PACT) Identifies Non-Adherence in Pediatric Kidney Transplantation
K. Freischlag,¹ V. Chen,² S. Nagaraj,² A. Chua,² E. Chambers.²
¹School of Medicine, Duke University, Durham, NC; ²Pediatrics, Duke University, Durham, NC.
Background: We have demonstrated that overall pre-transplant Psychosocial Assessment of Candidates for Transplantation (PACT) scores can identify high risk pediatric kidney recipients. In this pilot…
2018 American Transplant Congress
Everolimus and the Risk of Graft Loss or Death in Kidney Transplant Recipients: A Trial-Based Linkage Study
T. Ying,^1,2 G. Wong, W. Lim, G. Russ, H. Pilmore, J. Kanellis, D. Goodman, P. Trevillian, S. Campbell, M. Suranyi, M. Mathew, R. Faull, R. Masterson, R. Walker, P. O'Connell, S. Chadban.^1,2
¹Renal Medicine, Royal Prince Alfred Hospital, Camperdown, Australia; ²Kidney Node, Charles Perkins Centre, University of Sydney, Sydney, Australia.
Background: The use of mTORIs may be associated with a reduction of cancer incidence after kidney transplantation (KT) and improved graft function compared with calcineurin-inhibitor…
2018 American Transplant Congress
Assessment of Peak Levels and Metabolism Rates in African American (AA) and Non-AA Kidney Transplant Recipients (KTR) on Immediate-Release Tacrolimus (IR-tac)
T. Horwedel,¹ R. Sodhi,² D. Tsapapas,³ M. Mills,⁴ S. Patel,⁴ G. Towns.⁵
¹Barnes-Jewish Hospital, St. Louis, MO; ²St. Louis University, St. Louis, MO; ³Columbia University, New York, NY; ⁴Veloxis Pharmaceuticals, Cary, NC; ⁵University of Alabama, Birmingham, AL.
Trough-to-daily dose (C/D) ratio has been used as a simple method for evaluation of IR-tac metabolism rate. Recent studies have shown that fast metabolizers defined…
2018 American Transplant Congress
Development of Optimal Simplified Equation for Estimation of Mycophenolic Acid Exposure Following Enteric-Coated Mycophenolate Sodium Administration in Chinese Renal Transplant Recipients
W. Peng, C. Tian, Z. Chen, W. Xue, G. Wang, Q. Ye, X. Zhang, M. Gu, M. Zhao, C. Wang, C. Huang, J. Yan, W. Zhang, C. Ding, Y. Fu, S. Ye, X. Hu, R. Tan, M. Li, R. Deng, Y. Ke, W. Wu, M. Fan, J. Chen.
MyERA Study Group, Hangzhou, China.
Background: Limited sampling strategies (LSS) aids in overcoming the complexity of extensive PK sampling and supporting the calculation of mycophenolic acid (MPA) exposure. This study…
2018 American Transplant Congress
Pharmacokinetics of Mycophenolic Acid Following Enteric-Coated Mycophenolate Sodium Administration in Chinese Renal Transplant Recipients
W. Peng, C. Tian, Z. Chen, W. Xue, G. Wang, Q. Ye, X. Zhang, M. Gu, M. Zhao, C. Wang, C. Huang, J. Yan, W. Zhang, C. Ding, Y. Fu, S. Ye, X. Hu, R. Tan, M. Li, R. Deng, Y. Ke, W. Wu, M. Fan, J. Chen.
MyERA Study Group, Hangzhou, China.
Background: Mycophenolic acid (MPA), active component of mycophenolate mofetil (MMF) or enteric-coated mycophenolate sodium (EC-MPS), is the most commonly used immunosuppressant in renal transplant recipients…
2018 American Transplant Congress
National Survey of Living Donor Coordinators to Identify Barriers to Living Donation
D. Moore,¹ M. Dietrich,¹ P. Buerhaus,² J. Rodrigue,³ A. Minnick.¹
¹Vanderbilt University, Nashville; ²Montana State University, Bozeman; ³Beth Israel Deaconess MC, Boston.
Purpose: Living donor coordinators (LDC) are the frontline healthcare providers for potential living kidney donors. However, there is limited research regarding LDC perceptions of barriers…