ATC Abstracts

American Transplant Congress abstracts

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  • 2018 American Transplant Congress

    Predicting Outcomes of Rat Vascularized Composite Allotransplants through Quantitative Measurement of Chimerism with PCR-Amplified Short Tandem Repeat

    H. Cheng,1 X. Huang,2 C-.F. Lin,1 N. AL Deek,2 L. Shih,2 C-.H. Lin,1,2 F-.C. Wei.1,2,3

    1Center for Vascularized Composite Allotransplantation, Linkou Chang Gung Memorial Hospital, Gueishan, Taoyuan, Taiwan; 2Department of Plastic and Reconstructive Surgery, Linkou Chang Gung Memorial Hospital, Gueishan, Taoyuan, Taiwan; 3College of Medicine, Chang Gung University, Gueishan, Taoyuan, Taiwan.

    Background: Chimerism, defined as coexistence of donor and recipient cells, has been associated with induction and maintenance of tolerance to allotransplants. Although most studies have…
  • 2018 American Transplant Congress

    The Novel Polymer Pro-Drug APP-103 Reduces I/R Injury and Improves Graft Function in a Pre-Clinical Renal Transplant Model

    K. Minami,1,3 H. Uehara,1,3 A. Elkhal,1,3 A. Weins,3 S. Bae,2,3 J. Reder,4 B. Houser,4 P. Kang,2,3 S. Tullius.1,3

    1Transplant Surgery Division, Department of Surgery, Brigham and Women's Hospital, Boston, MA; 2Beth Israel Deaconess Medical Center, Boston, MA; 3Harvard Medical School, Boston, MA; 4Celdara Medical, LLC, Lebanon, NH.

    Purpose: Ischemia-reperfusion injury (IRI) is the strongest non-HLA factor that augments allogenicity of transplanted organs. Damage subsequent to IRI is critically linked to an abundance…
  • 2018 American Transplant Congress

    Lower Incidence of De Novo Donor-Specific Antibodies against HLA-DR in ABO-Incompatible Renal Transplantation

    M. Okada,1 K. Futamura,1 T. Hiramitsu,1 M. Tsujita,1 N. Goto,1 S. Narumi,1 Y. Watarai,1 K. Iwasaki,2 T. Kobayashi.2

    1Department of Transplant and Endocrine Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan; 2Department of Transplant Surgery, Aichi Medical University, Nagakute, Japan.

    IntroductionDe novo DSA-induced chronic antibody-mediated rejection (AMR) is one of major obstacles to long term graft survival. We have reported that anti-A/B antibody binding could…
  • 2018 American Transplant Congress

    Immunogenic HLA Mismatches and Evidence That Belatacept May Be the First Therapy Able to Prevent DQ De Novo DSA: An Analysis of the BENEFIT and BENEFIT-EXT Trial Cohorts

    M. Everly,1 V. Jucaud,1 M. Roberts,2 H. Gebel,3 R. Bray.3

    1Terasaki Research Institute, Los Angeles, CA; 2Immunology Biomarker Group, Bristol-Myers Squibb, Princeton, NJ; 3Pathology & Laboratory Medicine, Emory University School of Medicine, Atlanta, GA.

    The use of belatacept over cyclosporine is associated with lower rates of DSA development in adult kidney transplantation. However, the effect of belatacept on the…
  • 2018 American Transplant Congress

    10-Year Outcomes of Renal Transplantation from Circulatory Death Donors with Increased Terminal Creatinine

    Y. Tomita, K. Iwadoh, I. Nakajima, S. Fuchinoue.

    Surgery III, Tokyo Women's Medical University, Tokyo, Japan.

    Background: To alleviate chronic renal graft shortages in Japan, donation after circulatory death (DCD) is an increasingly used organ resource. Organs from DCD donors with…
  • 2018 American Transplant Congress

    De Novo or Early Conversion to Everolimus and the Risk of Skin Cancers in Kidney Transplant Recipients: A Trial-Based Linkage Study

    T. Ying,1,2 G. Wong, W. Lim, G. Russ, H. Pilmore, J. Kanellis, D. Goodman, P. Trevillian, S. Campbell, M. Suranyi, M. Mathew, R. Faull, R. Masterson, R. Walker, P. O'Connell, S. Chadban.1,2

    1Renal Medicine, Royal Prince Alfred Hospital, Camperdown, Australia; 2Kidney Node, Charles Perkins Centre, University of Sydney, Camperdown, Australia.

    Introduction: Non-melanoma skin cancers (NMSC) are a significant cause of morbidity in kidney transplant (KT) recipients. Choice of immunosuppressive regimen may modify the risk of…
  • 2018 American Transplant Congress

    Once Daily CNI Administration Based on Pharmacodynamic Analysis for Preventing Viral Infection

    Y. Matsuoka,1 K. Iwasaki,2 Y. Miwa,2 K. Horimi,1 K. Uchida,2 T. Kobayashi.1

    1Renal Transplant Surgery, Aichi Medical University, Nagakute City, Aichi, Japan; 2Kidney Disease and Transplant Immunology, Aichi Medical University, Nagakute City, Aichi, Japan.

    BackgroundInfectious complications under immunosuppressive therapy are inevitable problems. Viral infection (include reactivation) occurs at a certain frequency even if immunosuppressive agents are totally adjusted by…
  • 2018 American Transplant Congress

    Transplant Cost Reduction in a Developing Country: “The Case of Guatemala”

    S. Méndez,1 B. Remey,2 E. Reyes,1 A. Aguilar-González,1 R. Lou-Meda.1

    1Servicio de Nefrología, Hipertensión, Diálisis y Trasplante Hospital Roosevelt/FUNDANIER, Guatemala, Guatemala; 2Department of Pharmaceutical Chemistry, Universidad del Valle de Guatemala, Guatemala, Guatemala.

    Background: Guatemala, south-west of Mexico has a population of approximately 16 million people of which 60% are younger than 20 years. As any other developing…
  • 2018 American Transplant Congress

    Opioid Use Following Ultrasound-Guided Transverse Abdominis Plane Blocks in Living Donor Nephrectomy Patients

    E. Henricksen,1 D. Quan,1 C. Freise.2

    1Department of Pharmacy, University of California, San Francisco, San Francisco, CA; 2Department of Surgery, University of California, San Francisco, San Francisco, CA.

    Purpose: Post-operative pain management is of major concern in living donor nephrectomy patients. Opioids are often used for post-surgical pain, however they are associated with…
  • 2018 American Transplant Congress

    The Impact of Duration on Dialysis on the Pre-Transplant Allosensitization According to Panel Reactive Antibody Levels

    Y. Jung,1 D. Kim,1 J. Lee,1 S. Song,2 J. Lee,3 B. Kim,4 J. Lee,1 S. Kim,1 M. Kim,1 S. Kim,1 Y. Kim,1 K. Huh.1

    1Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea; 2Department of Surgery, College of Medicine, Ewha Women's University, Seoul, Republic of Korea; 3Department of Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea; 4Departments of Nephrology, Yonsei University College of Medicine, Seoul, Republic of Korea.

    Purpose : Presensitization to human leukocyte antigen(HLA) is one of the most important barriers to overcome in the field of renal transplantation. Due to the…
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