Am J Transplant, Volume 18, Suppl 3 Archives - Page 193 of 211 - ATC Abstracts

2018 American Transplant Congress
Improving Prognostication amongst Patients Undergoing Liver Transplantation for Hepatocellular Carcinoma: An International, 16-Center Study to Validate and Recalibrate HALTHCC
D. Firl,¹ K. Sasaki,¹ S. Kimura,² W. Dumronggittigule,³ A. Gorgen,⁴ J. Lerut,⁵ M. Rossi,⁶ U. Cillo,⁷ A. Viveiros,⁸ E. Tsochatzis,⁹ G. Otto,¹⁰ G. Ettorre,¹¹ G. Tisone,¹² M. Vivarelli,¹³ S. Agnes,¹⁴ J. Markmann,² T. Ikegami,¹⁵ T. Kaido,¹⁶ G. Sapisochin,⁴ V. Agopian,³ Q. Lai,^5,6 F. Aucejo.¹
¹CCF, Cleveland; ²MGH, Boston; ³UCLA, LA; ⁴UHN, Toronto, Canada; ⁵SLH, Louvain, Belgium; ⁶UH, Rome, Italy; ⁷UP, Padua, Italy; ⁸MUI, Innsbruck, Austria; ⁹UCL, London, United Kingdom; ¹⁰UM, Mainz, Germany; ¹¹SCH, Rome, Italy; ¹²TVU, Rome, Italy; ¹³AOU, Torrette Ancona, Italy; ¹⁴AGH, Rome, Italy; ¹⁵KU, Kyoto, Japan; ¹⁶KU, Kyushu, Japan.
Objective: Prognosticating outcomes in liver transplant (LT) for hepatocellular carcinoma (HCC) continues to challenge the field. Whereas adoption of the binary Milan Criteria (MC) generalized…
2018 American Transplant Congress
Mechanisms of DEPTOR Function in CD4⁺ T Cell Subsets
J. Wedel,¹ K. Liu,¹ P. Sage,² M. Laplante,³ D. Briscoe.¹
¹Transplant Research Program, Boston Children's Hospital, Harvard Medical School, Boston; ²Department of Microbiology and Immunobiology, Harvard Medical School, Boston; ³IUCP, Lavel University, Quebec, Canada.
We have previously observed that the cell intrinsic modulatory protein DEPTOR (DEP) stabilizes Foxp3 expression, enhances Treg function and inhibits Treg dedifferentiation. In vivo, sustained…
2018 American Transplant Congress
Liver Transplantation Outcomes after Share 35: Analysis of NASH Recipients from UNOS Database
Y. Zhang,¹ M. Boktour.²
¹Department of Biostatistics, University of Texas Health Science Center, Houston, TX; ²Department of Surgery, Methodist Hospital, Houston, TX.
Background: Non-alcoholic steatohepatitis (NASH) is a rapidly growing indication for liver transplantation (LT) among patients with end-stage liver diseases. The study aimed to examine the…
2018 American Transplant Congress
Specific Monocyte Memory to Allogeneic MHC Mediated by Paired Immunoglobulin Receptors (PIR)
H. Dai,¹ P. Lan,² A. Friday,¹ A. Williams,¹ M. Oberbarnscheidt,¹ X. Li,² F. Lakkis.¹
¹Surgery, University of Pittsburgh, Pittsburgh, PA; ²Immunobiology, Houston Methodist Hospital, Houston, TX.
Monocytes distinguish between self and allogeneic non-self and contribute to allograft rejection by generating mature, IL-12+, DCs. The initial trigger of monocyte differentiation to DCs…
2018 American Transplant Congress
Serial Monitoring of Resolution of Sub-Clinical Acute Rejection (subAR) in Kidney Transplant Recipients (KTR) Using a Gene Expression Profile (GEP)
L. Zhao,¹ B. Armstrong,² J. Friedewald,¹ T. Whisenant,³ S. Kurian,³ R. Heilman,⁴ E. Poggio,⁵ C. Marsh,³ P. Baliga,⁶ N. Bridges,⁷ J. Odim,⁷ M. Brown,⁷ D. Ikle,² J. Charette,¹ S. Brietigam,¹ N. Sustento-Reodica,¹ M. Kandpal,¹ D. Salomon,³ M. Abecassis.¹
¹Northwestern, Chicago; ²Rho, Chapel Hill; ³Scripps, La Jolla; ⁴Mayo AZ, Scottsdale; ⁵Cleveland Clinic, Cleveland; ⁶MUSC, Charleston; ⁷NIAID, Bethesda.
BACKGROUNDSubAR can currently only be detected using surveillance biopsies (SBx) and is associated with poor long-term graft outcomes. Response to treatment is difficult to assess.…
2018 American Transplant Congress
IgM HLA DSAs Do Not Alter the Outcomes of Renal Allograft Rejection
A. Gueret-Wardle,¹ P. Dodd,¹ G. Lucisano,¹ S. Hassan,¹ P. Brookes,² E. Santos-Nunez,² N. Firmin,² D. Goodall,¹ C. Roufosse,¹ M. Willicombe,¹ D. Taube.¹
¹Renal and Transplant Centre, Imperial College Healthcare NHS Trust, London, United Kingdom; ²Histocompatibility and Immunogenetics, Imperial College Healthcare NHS Trust, London, United Kingdom.
Introduction: whilst IgG HLA DSAs are associated with renal allograft rejection and graft loss, the role of IgM HLA DSAs is controversial. We investigate the…
2018 American Transplant Congress
Characterization of Exosomal DNA from Human Lung Transplant Recipients
S. Bansal, M. Sharma, R. Walia, R. Bremner, M. Smith, T. Mohanakumar.
Norton Thoracic Institute, St. Joseph's Hosp & Med Ctr, Phoenix.
Exosomes are small vesicles which contains biological molecules including proteins, RNA`s and miRNAs. It has been reported that exosomes may contain ds DNA originated from…
2018 American Transplant Congress
Urinary TIMP-2 Predicts the Presence and Duration of Delayed Graft Function in DCD Kidney Transplant Recipients
J. Bank,¹ R. Ruhaak,² D. Soonawala,¹ F. Romijn,² C. van Kooten,¹ C. Cobbaert,² H. de Fijter.¹
¹Nephrology, Leiden University Medical Center, Leiden, Netherlands; ²Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, Netherlands.
Introduction: Tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) are promising biomarkers in acute kidney injury. Here, we investigated the performance…
2018 American Transplant Congress
CCAAT-Enhancer-Binding Protein Homologous Protein Promotes Liver Ischemia and Reperfusion Injury by Inhibiting Beclin-1-Mediated Autophagy in Hepatocytes
H. Zhou,¹ Z. Rao,¹ Y. Xia,¹ R. Liu,¹ S. Zhou,¹ X. Wang,¹ Y. Zhai,¹ L. Lu.¹
¹First Affiliated Hospital of Nanjing Medical University, Nanjing, China; ²David Geffen School of Medicine at University of California-Los Angeles, Los Angeles.
Background and Aims:Critical role of endoplasmic reticulum (ER) stress has been found in ischemia and reperfusion(IR) injury models. However, the role of CCAAT-Enhancer-Binding Protein Homologous…
2018 American Transplant Congress
Overexpression of BAX, NOL3, and XIAP Apoptotic Genes Participates in Calcineurin Inhibitors Nephrotoxicity: New Insights into Chronic Allograft Dysfunction
L. Garcia-Covarrubias,¹ G. Queipo,² M. Fonseca,² D. Alcantara,¹ P. Prieto,¹ H. Diliz,¹ A. Garcia,¹ H. Hinojosa,¹ A. Cicero,¹ G. Melendez,³ M. Alamilla,³ R. Lascurain,⁴ V. Soto.⁵
¹Transplantation, Hospital General de Mexico, Mexico City, Mexico; ²Genetics, Hospital General de Mexico, Mexico City, Mexico; ³Research, Hospital General de Mexico, Mexico City, Mexico; ⁴Faculty of Medicine, UNAM, Mexico City, Mexico; ⁵Pathology, Hospital General de Mexico, Mexico City, Mexico.
Introduction: Calcineurin inhibitors toxicity (CNIT) is a factor that limit the outcome of renal transplantation graft. The hypoxia causes histological data as nodular hyalinosis, hyalinosis,…