ATC Abstracts

American Transplant Congress abstracts

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  • 2018 American Transplant Congress

    Precision Medicine for Determining the Efficacy of a Novel Belatacept Regimen

    J. Shoji, J. Leung, E. Tavares, Q. Tang, F. Vincenti.

    Transplant Nephrology, UCSF, San Francisco, CA.

    IntroBelatacept is increasingly used as maintenance immunosuppression to improve long term outcomes in kidney transplant. Since acute rejection in patients on belatacept have been noted…
  • 2018 American Transplant Congress

    Use of Proton-Pump Inhibitors is Associated with Lower Magnesium and Iron Status and Excess Mortality in Renal Transplant Recipients

    A. Gomes-Neto,1 R. Douwes,1 M. Eisenga,1 S. Berger,1 R. Gans,1 E. Berg,1 G. Navis,1 H. Blokzijl,2 S. Bakker.1

    1Nephrology, UMCG, Groningen, Netherlands; 2Gastroenterology and Hepatology, UMCG, Groningen, Netherlands.

    BackgroundProton-pump inhibitor (PPI) use is common in renal transplant recipients (RTR). However, PPI use may induce micronutrient deficiencies and has been associated with increased mortality…
  • 2018 American Transplant Congress

    Worsening Racial/Ethnic Disparities in Pediatric Kidney Transplant Outcomes in the US

    T. Purnell, X. Luo, L. Cooper, D. Crews, K. Covarrubias, A. Massie, D. Segev.

    Johns Hopkins, Baltimore.

    Purpose: We recently demonstrated narrowed racial/ethnic disparities in adult kidney transplant (KT) outcomes in the US. The goal of this study was to examine twenty-year…
  • 2018 American Transplant Congress

    Elevated Serum Penteraxin in Cardiac Allograft Antibody Mediated Rejection: From Cytokine Arrays to Patients with ABMR

    O. Moussa,3 M. Kavarana,2 L. Klingman,1 J. Felius,1 S. Hall,1 M. Askar.1

    1Baylor Research Institute, Dallas; 2Medical University of South Carolina, Charleston; 3University of Michigan, Ann Arbor, MI.

    Pentraxin 3 (PTX3) is soluble protein that has been implicated in in atherosclerosis, endothelial function, hypertension, myocardial infarction and angiogenesis (Fornai et al., 2016). We…
  • 2018 American Transplant Congress

    Prospective, Multi-Center Observational Study of Cell-Mediated Immunity for Cytomegalovirus Infection in Kidney Transplant Recipients

    D. Kumar,1 P. Chin-Hong,2 L. Kayler,3 D. Wojciechowski,4 A. Limaye,5 O. Gaber,6 S. Ball,7 A. Mehta,8 T. Blanchard,9 C. Kotton.4

    1UHN, Toronto, Canada; 2UCSF, San Francisco; 3ECMC, Buffalo; 4MGH, Boston; 5UOWMC, Seattle; 6WCMC, Houston; 7UHB, Birmingham, United Kingdom; 8EmoryU, Atlanta; 9Oxford Diag, Marlborough.

    Background:T-cell-mediated immunity (CMI) is crucial for the control of CMV infection post-transplant. We evaluated a novel EliSpot assay to determine whether CMI results could predict…
  • 2018 American Transplant Congress

    Resuscitation and Viability Testing of Initially Declined Livers Using Sequential Hypo- and Normothermic Machine Perfusion with an Acellular Fluid

    Y. de Vries,1,2 A. Matton,1,2 S. Karangwa,1,2 M. Nijsten,3 R. de Kleine,2 A. van den Berg,4 V. de Meijer,2 P. Meyer,5 M. de Boer,2 R. Porte.2

    1Surgical Research Laboratory, University of Groningen, University Medical Center Groningen, Groningen, Netherlands; 2Section of HPB Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, Netherlands; 3Department of Critical Care, University Medical Center Groningen, Groningen, Netherlands; 4Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, Netherlands; 5Department of Anesthesiology, University Medical Center Groningen, Groningen, Netherlands.

    While end-ischemic dual hypothermic oxygenated machine perfusion (DHOPE) resuscitates mitochondria and reduces ischemia-reperfusion injury, normothermic machine perfusion (NMP) allows for ex-situ functional testing of donor…
  • 2018 American Transplant Congress

    Prospective, Double Blind, Randomized Trial Comparing the Use of Ketorolac and Lyrica versus SOC+placebo during Live Donor Nephrectomy for Transplant

    J. Campsen,1 T. Call,2 A. Rosales,1 C. Allen,3 A. Presson,3 R. Kim.1

    1Trasplantation and Advanced Hepatobiliary Surgery, University of Utah, Salt Lake City, UT; 2Anesthesiology, University of Utah, Salt Lake City, UT; 3Epidemiology, University of Utah, Salt Lake City, UT.

    Opioid exposure is a concern after live donation (LD) for transplant. We theorized that a protocol using pregablin pre-operation to desensitize nerves followed by ketorolac…
  • 2018 American Transplant Congress

    BK Polyomavirus (BKPyV)-Specific T Cells as a Diagnostic and Prognostic Marker for BKPyV-Infections after Pediatric Kidney Transplantation

    T. Ahlenstiel-Grunow,1 M. Sester,2 U. Sester,3 L. Pape.1

    1Pediatric Nephrology, Hannover Medical School, Hannover, Germany; 2Transplant and Infection Immunology, Saarland University, Homburg, Germany; 3Internal Medicine IV, Saarland University, Homburg, Germany.

    After kidney transplantation (KTx) immunosuppressive therapy causes an impaired cellular immune defense resulting in an increased risk of BKPyV-nephropathy (BKPyVAN). Prognostic markers for the outcome…
  • 2018 American Transplant Congress

    Incidence of Acute Cellular Rejection in Liver Transplant Patients Receiving Direct Acting Antivirals for Hepatitis C Treatment

    D. Bley,1 L. Sagardia,1 R. Ford,2 S. Todd.1

    1Pharmacy, Emory University Hospital, Atlanta, GA; 2School of Medicine, Emory University, Atlanta, GA.

    Direct acting antivirals (DAAs) have been used for the treatment of hepatitis C (HCV) in liver transplant patients since early on after their approval, however…
  • 2018 American Transplant Congress

    Basiliximab Induction in HIV-Positive Renal Transplant Recipients Compared to an HIV-Negative Cohort

    J. Schulte,1 C. Richardson,1 V. Stosor,2 K. Cunningham,1 C. D'Agostino,1 C. Kane.1

    1Pharmacy, Northwestern Memorial Hospital, Chicago; 2Infectious Diseases and Organ Transplantation, Northwestern Memorial Hospital, Chicago.

    Purpose: There is an elevated risk of acute rejection in HIV+ renal transplant recipients and continued evaluation of the most appropriate induction therapy remains. Use…
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