2018 American Transplant Congress
Serial Monitoring of Resolution of Sub-Clinical Acute Rejection (subAR) in Kidney Transplant Recipients (KTR) Using a Gene Expression Profile (GEP)
BACKGROUNDSubAR can currently only be detected using surveillance biopsies (SBx) and is associated with poor long-term graft outcomes. Response to treatment is difficult to assess.…2018 American Transplant Congress
IgM HLA DSAs Do Not Alter the Outcomes of Renal Allograft Rejection
Introduction: whilst IgG HLA DSAs are associated with renal allograft rejection and graft loss, the role of IgM HLA DSAs is controversial. We investigate the…2018 American Transplant Congress
Characterization of Exosomal DNA from Human Lung Transplant Recipients
Norton Thoracic Institute, St. Joseph's Hosp & Med Ctr, Phoenix.
Exosomes are small vesicles which contains biological molecules including proteins, RNA`s and miRNAs. It has been reported that exosomes may contain ds DNA originated from…2018 American Transplant Congress
Urinary TIMP-2 Predicts the Presence and Duration of Delayed Graft Function in DCD Kidney Transplant Recipients
Introduction: Tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) are promising biomarkers in acute kidney injury. Here, we investigated the performance…2018 American Transplant Congress
CCAAT-Enhancer-Binding Protein Homologous Protein Promotes Liver Ischemia and Reperfusion Injury by Inhibiting Beclin-1-Mediated Autophagy in Hepatocytes
Background and Aims:Critical role of endoplasmic reticulum (ER) stress has been found in ischemia and reperfusion(IR) injury models. However, the role of CCAAT-Enhancer-Binding Protein Homologous…2018 American Transplant Congress
Overexpression of BAX, NOL3, and XIAP Apoptotic Genes Participates in Calcineurin Inhibitors Nephrotoxicity: New Insights into Chronic Allograft Dysfunction
Introduction: Calcineurin inhibitors toxicity (CNIT) is a factor that limit the outcome of renal transplantation graft. The hypoxia causes histological data as nodular hyalinosis, hyalinosis,…2018 American Transplant Congress
Title: Donor-Derived Cell Free DNA Predicts Development of Clinically Significant Changes in Donor Specific Antibody Following Kidney Transplant
Background: Recently, high immunologic risk patients comprise a significant percentage of the total adult renal transplants performed yearly. Surveillance management of these patients and interpretation…2018 American Transplant Congress
Can We Expect the “Unexpected”?
Northwestern University, Chicago.
A known, seemingly paradoxical, phenomenon of the HLA system is the high overall degree of homology among different HLA alleles, despite vast polymorphism in the…2018 American Transplant Congress
Do Protocol Biopsies in the Highly Sensitized Improve Renal Allograft Survival? A Single Center Evaluation of 2 Year Graft Function
Organ Transplant Center, University of Iowa, Iowa City, IA.
Highly sensitized kidney transplant recipients (hsKTR) are at an increased risk of antibody mediated rejection (AMR). Following implementation of the new kidney allocation system (KAS)…2018 American Transplant Congress
B-Cell Depletion with Rituximab Exacerbates Anti-Donor CD4+ T-Cell Responses in Patients with Donor-Specific Anti-Human Leukocyte Antigen Antibodies
Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.
Background: It has been reported that preformed donor-specific anti-human leukocyte antigen antibodies (DSAs) were associated with poor graft outcomes in kidney transplant recipients. To eliminate…
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