Am J Transplant, Volume 18, Suppl 3 Archives - Page 186 of 211 - ATC Abstracts

2018 American Transplant Congress
Elevated Serum Penteraxin in Cardiac Allograft Antibody Mediated Rejection: From Cytokine Arrays to Patients with ABMR
O. Moussa,³ M. Kavarana,² L. Klingman,¹ J. Felius,¹ S. Hall,¹ M. Askar.¹
¹Baylor Research Institute, Dallas; ²Medical University of South Carolina, Charleston; ³University of Michigan, Ann Arbor, MI.
Pentraxin 3 (PTX3) is soluble protein that has been implicated in in atherosclerosis, endothelial function, hypertension, myocardial infarction and angiogenesis (Fornai et al., 2016). We…
2018 American Transplant Congress
Prospective, Multi-Center Observational Study of Cell-Mediated Immunity for Cytomegalovirus Infection in Kidney Transplant Recipients
D. Kumar,¹ P. Chin-Hong,² L. Kayler,³ D. Wojciechowski,⁴ A. Limaye,⁵ O. Gaber,⁶ S. Ball,⁷ A. Mehta,⁸ T. Blanchard,⁹ C. Kotton.⁴
¹UHN, Toronto, Canada; ²UCSF, San Francisco; ³ECMC, Buffalo; ⁴MGH, Boston; ⁵UOWMC, Seattle; ⁶WCMC, Houston; ⁷UHB, Birmingham, United Kingdom; ⁸EmoryU, Atlanta; ⁹Oxford Diag, Marlborough.
Background:T-cell-mediated immunity (CMI) is crucial for the control of CMV infection post-transplant. We evaluated a novel EliSpot assay to determine whether CMI results could predict…
2018 American Transplant Congress
Resuscitation and Viability Testing of Initially Declined Livers Using Sequential Hypo- and Normothermic Machine Perfusion with an Acellular Fluid
Y. de Vries,^1,2 A. Matton,^1,2 S. Karangwa,^1,2 M. Nijsten,³ R. de Kleine,² A. van den Berg,⁴ V. de Meijer,² P. Meyer,⁵ M. de Boer,² R. Porte.²
¹Surgical Research Laboratory, University of Groningen, University Medical Center Groningen, Groningen, Netherlands; ²Section of HPB Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, Netherlands; ³Department of Critical Care, University Medical Center Groningen, Groningen, Netherlands; ⁴Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, Netherlands; ⁵Department of Anesthesiology, University Medical Center Groningen, Groningen, Netherlands.
While end-ischemic dual hypothermic oxygenated machine perfusion (DHOPE) resuscitates mitochondria and reduces ischemia-reperfusion injury, normothermic machine perfusion (NMP) allows for ex-situ functional testing of donor…
2018 American Transplant Congress
Prospective, Double Blind, Randomized Trial Comparing the Use of Ketorolac and Lyrica versus SOC+placebo during Live Donor Nephrectomy for Transplant
J. Campsen,¹ T. Call,² A. Rosales,¹ C. Allen,³ A. Presson,³ R. Kim.¹
¹Trasplantation and Advanced Hepatobiliary Surgery, University of Utah, Salt Lake City, UT; ²Anesthesiology, University of Utah, Salt Lake City, UT; ³Epidemiology, University of Utah, Salt Lake City, UT.
Opioid exposure is a concern after live donation (LD) for transplant. We theorized that a protocol using pregablin pre-operation to desensitize nerves followed by ketorolac…
2018 American Transplant Congress
BK Polyomavirus (BKPyV)-Specific T Cells as a Diagnostic and Prognostic Marker for BKPyV-Infections after Pediatric Kidney Transplantation
T. Ahlenstiel-Grunow,¹ M. Sester,² U. Sester,³ L. Pape.¹
¹Pediatric Nephrology, Hannover Medical School, Hannover, Germany; ²Transplant and Infection Immunology, Saarland University, Homburg, Germany; ³Internal Medicine IV, Saarland University, Homburg, Germany.
After kidney transplantation (KTx) immunosuppressive therapy causes an impaired cellular immune defense resulting in an increased risk of BKPyV-nephropathy (BKPyVAN). Prognostic markers for the outcome…
2018 American Transplant Congress
Incidence of Acute Cellular Rejection in Liver Transplant Patients Receiving Direct Acting Antivirals for Hepatitis C Treatment
D. Bley,¹ L. Sagardia,¹ R. Ford,² S. Todd.¹
¹Pharmacy, Emory University Hospital, Atlanta, GA; ²School of Medicine, Emory University, Atlanta, GA.
Direct acting antivirals (DAAs) have been used for the treatment of hepatitis C (HCV) in liver transplant patients since early on after their approval, however…
2018 American Transplant Congress
Basiliximab Induction in HIV-Positive Renal Transplant Recipients Compared to an HIV-Negative Cohort
J. Schulte,¹ C. Richardson,¹ V. Stosor,² K. Cunningham,¹ C. D'Agostino,¹ C. Kane.¹
¹Pharmacy, Northwestern Memorial Hospital, Chicago; ²Infectious Diseases and Organ Transplantation, Northwestern Memorial Hospital, Chicago.
Purpose: There is an elevated risk of acute rejection in HIV+ renal transplant recipients and continued evaluation of the most appropriate induction therapy remains. Use…
2018 American Transplant Congress
Incidence of Epstein Barr Virus (EBV) DNAemia in EBV-Seronegative Solid Organ Transplant (SOT) Recipients with EBV-Seropositive Donors
C. Burton,¹ C. Mabilangan,² J. Preiksaitis.²
¹Pediatrics, University of Alberta, Edmonton, Canada; ²Medicine, University of Alberta, Edmonton, Canada.
Purpose: Since 2002, a pre-emptive approach to post-transplant lymhoproliferative disease prevention has been used at our center that includes EBV viral load (VL) monitoring in…
2018 American Transplant Congress
Inhibition of IL-1R1 Signaling Delays Costimulation Blockade–Resistant Allograft Rejection by Preventing CD8 TEM Expansion
Y. Liu, Y. Dong, D. Mathews, A. Ghosh, A. Adams.
Department of Surgery, Emory University, Atlanta, GA.
The clinical utilization of Costimulaiton Blockade (CoB) led to improved long-term patient outcomes, but wider adoption of is hampered by increased rates of acute cellular…
2018 American Transplant Congress
Prospective Analysis of EBV+ PTLD Incidence in Pediatric Transplant Recipients in the Modern Era
O. Martinez,¹ S. Krams,¹ M. Lapasaran,¹ S. Boyd,² D. Bernstein,² C. Twist,³ K. Weinberg,² D. Gratzinger,² B. Tan,² B. Armstrong,⁴ D. Ikle,⁴ M. Brown,⁵ M. Robien,⁵ C. Esquivel,¹ The CTOTC-06 Investigators.
¹Surgery/Division of Abdominal Transplantation, Stanford University School of Medicine, Stanford; ²Stanford University School of Medicine, Stanford; ³Roswell Park, Buffalo; ⁴Rho, Chapel Hill; ⁵NIAID/NIH, Bethesda.
Post-transplant lymphoproliferative disorder (PTLD) remains a serious problem in the pediatric transplant population. The Clinical Trials of Organ Transplantation in Children (CTOTC)-06 is an NIAID-sponsored…