Am J Transplant, Volume 18, Suppl 3 Archives - Page 174 of 211 - ATC Abstracts

2018 American Transplant Congress
p16^INK4a Deletion in Vascular Endothelium Improves Kidney Regeneration Post Ischemia Reperfusion Injury
A. Melk,¹ A. Baisantry,^1,2 S. Wang,¹ F. Kubaink,¹ R. Bhayadia,¹ R. Schmitt.²
¹Department of Kidney, Liver & Metabolic Diseases, MHH, Hannover, Germany; ²Department of Nephrology, MHH, Hannover, Germany.
Background: Ischemia Reperfusion injury (IRI) mediated cellular senescence in kidney allografts has been linked to a loss in regenerative potential and delayed graft function. Injured…
2018 American Transplant Congress
Improving Prediction of Post-Transplant Death and Graft Loss with Expanded Clinical Data Collection
R. Sung,¹ J. Magee,¹ M. Schnitzler,² N. Dzebisashvili,³ K. Lentine,² L. Ly,¹ D. Axelrod.⁴
¹University of Michigan, Ann Arbor; ²Saint Louis University, St. Louis; ³XynManagement, Inc, St. Louis.
US transplant centers are graded for patient and graft survival of their recipients based on comparison to risk-adjusted expectations using elements captured in the national…
2018 American Transplant Congress
Post‐Donation eGFR Levels Predicts New‐Onset Antihypertensive Medication Use after Living Kidney Donation
K. Lentine,¹ D. Segev,² N. Lam,³ A. Garg,⁴ A. Naik,⁵ D. Axelrod,⁶ H. Xiao,¹ M. Henderson,² A. Massie,² B. Kasiske,⁷ G. Hess,⁸ C. Hsu,⁹ D. Brennan,² M. Schnitzler.¹
¹Saint Louis Univ, St. Louis; ²Johns Hopkins, Baltimore; ³Univ Alberta, Edmonton, Canada; ⁴Western Univ, Ontario, Canada; ⁵Univ Michigan, Ann Arbor; ⁶Lahey Clinic, Burlington; ⁷Hennepin County, Minneapolis; ⁸Symphony Health, Conshohocken; ⁹UCSF, San Francisco.
Limited data are available on the outcome implications of renal function after living kidney donation.We constructed a novel database linking SRTR registry identifiers, serum creatinine…
2018 American Transplant Congress
The Predictive Power of MELD is Decreasing in the Era of Older, Sicker Patients
E. Godfrey,¹ J. Lai,² T. Miloh,³ N. Galvan,¹ R. Cotton,¹ C. O'Mahony,¹ J. Vierling,¹ N. Sussman,¹ A. Rana.¹
¹Department of Surgery, Baylor College of Medicine, Houston, TX; ²Department of Medicine, University of California, San Francisco, San Francisco, CA; ³Department of Pediatrics, Baylor College of Medicine, Houston, TX.
PurposeThe field of liver transplantation has shifted considerably in the MELD era. Liver allocation, immunosuppression, and etiologies of liver failure have changed over time, and…
2018 American Transplant Congress
Economic Evaluation of Contemporary Kidney Transplant Practice
D. Axelrod,¹ M. Schnitzler,² H. Xiao,² W. Irish,³ J. Tuttle-Newhall,³ S-.H. Chang,⁴ B. Kasiske,⁵ T. Alhamad,⁴ K. Lentine.²
¹Lahey Clinic, Burlington; ²Saint Louis University, St. Louis; ³East Carolina University, Greeneville; ⁴Washington University, St. Louis; ⁵Hennepin County, Minneapolis.
Kidney transplantation (KTx) has been established as the optimal therapy for medically suitable patients with end-stage renal disease, prolonging survival and reducing health care spending.…
2018 American Transplant Congress
Information Needs of Adolescent Transplant Recipients Transitioning to Adult Care
B. Kosmach-Park,¹ D. Shellmer,² C. Nguyen,³ G. Mazariegos.²
¹Department of Transplant Surgery, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA; ²Hillman Center for Pediatric Transplantation, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA; ³Department of Pediatric Nephrology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.
Background: As adolescent and young adult (AYA) tx recipients transition to adulthood, a parallel transition in care is essential. The AYA should achieve skills for…
2018 American Transplant Congress
Activity Nanosensors for Early and Noninvasive Detection of Acute Organ Transplant Rejection
Q. Mac,¹ D. Mathews,² J. Kahla,¹ C. Stoffers,¹ O. Delmas,¹ B. Holt,¹ A. Adams,² G. Kwong.¹
¹Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA; ²Department of Surgery, Emory University School of Medicine, Atlanta, GA.
Purpose: We engineered activity nanosensors that sense anti-allograft T cell activity in vivo to noninvasively detect the onset of acute cellular rejection from urine.Methods: Granzyme…
2018 American Transplant Congress
IL-21 Regulates Creation of Tertiary Lymphoid Organs in Chronic Allograft Rejection
J. Breidenbach, C. Baum, P. Schroder, S. Stepkowski.
Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Science, Toledo, OH.
Background: IL-21 is a cytokine expressed almost exclusively by cells of the adaptive immune system, making it an attractive target for reducing chronic allograft rejection…
2018 American Transplant Congress
Early Steroid Withdrawal and Kidney Transplant Outcomes for Recipients with Delayed Graft Function
S. Bae, A. Massie, X. Luo, J. Garonzik Wang, D. Segev.
Johns Hopkins, Baltimore, MD.
Current guidelines suggest early steroid withdrawal (ESW) regimen for kidney transplant (KT) recipients with low immunological risk. Delayed graft function (DGF) is a risk factor…
2018 American Transplant Congress
The Advantage of Utilizing ABO and HLA Compatible Pairs in Kidney Paired Donation
A. Basu,¹ C. Kosberg,¹ H. Khamash,² M. Mai,³ M. Prieto,¹ C. Schinstock.¹
¹Nephrology and Hypertension, Mayo Clinic, Rochester, MN; ²Nephrology and Hypertension, Mayo Clinic, Scottsdale, AZ; ³Nephrology and Hypertension, Mayo Clinic, Jacksonville, FL.
BACKGROUND: Kidney paired donation (KPD) programs are mainly used to facilitate transplantation for candidates with ABO or HLA incompatible living donors. However, the benefit of…