Am J Transplant, Volume 18, Suppl 3 Archives - Page 166 of 211 - ATC Abstracts

2018 American Transplant Congress
Unbiased Sequencing of Urine Cell-Free DNA (cfDNA) to Evaluation Urine Virome and Associated Renal Allograft Damage
D. Dadhania,¹ P. Burnham,² J. Lee,¹ C. Snopkowski,¹ C. Li,¹ S. Albakry,¹ H. Yang,¹ T. Muthukumar,¹ I. De Vlaminck,² M. Suthanthiran.¹
¹Transplantation Medicine-Nephrology, Weill Cornell Medicine, NY, NY; ²Biomedical Engineering, Cornell University, Ithaca, NY.
Intro: Virus reactivation leading to graft damage is a frequent post-kidney transplant (KTx) complication. Immunosuppressed individuals are at risk for multiple virus infections simultaneously. Current…
2018 American Transplant Congress
All DQ DSA May Not Be Equal: Comparing Outcomes between De Novo DQ DSA Specificities
M. Everly,¹ K. Briley,² A. Nguyen,¹ V. Jucaud,¹ A. Maldonado,³ C. Haisch,² P. Bolin,² S. Kendrick,⁴ H. Jones,⁴ K. McLawhorn,⁴ D. Leeser,² L. Rebellato.²
¹Terasaki Research Institute, Los Angeles; ²East Carolina University, Greenville, NC; ³Vidant Medical Center, Greenville, NC; ⁴Eastern Nephrology Associates, Greenville, NC.
It is not known if development of de novo DSA (dnDSA) to different HLA-DQ mismatches (serological) are associated with equal risk to a patient's allograft…
2018 American Transplant Congress
National Study of Living Donor Program Protocols, Processes, and Resources within U.S. Transplant Centers
D. Moore,¹ M. Dietrich,¹ P. Buerhaus,² J. Rodrigue,³ A. Minnick.¹
¹Vanderbilt University, Nashville; ²Montana State University, Bonzeman; ³Beth Israel Deaconess MC, Boston.
Purpose: There is limited research that describes living donor (LD) program processes and protocols. This study aimed to describe LD program protocols, processes, and resources…
2018 American Transplant Congress
HLA-DR4 Matching and Hepatocellular Carcinoma Recurrence after Liver Transplantation
M. Xu, S. Garcia-Aroz, N. Vachharajani, Y. Lin, W. Chapman.
Department of Surgery, Section of Abdominal Transplantation, Washington University School of Medicine, St. Louis, MO.
PURPOSE: The phenomenon of graft versus host disease after orthotopic liver transplantation (OLT) is estimated at approximately 1-2%, suggesting that under some circumstances, the graft…
2018 American Transplant Congress
TORC1 Inhibition Protects Activated Human Regulatory T Cells from Self-Inflicted Damage via Granzyme B
B. Al Dulaijan, S. Eskandari, J. Karnyski, J. Assaker, S. Cai, A. Mansouri, M. Mohamed, J. Azzi.
Transplantation Research Center, BWH, Harvard Medical School, Boston, MA.
The safety and efficacy of adoptive transfer of regulatory T cells (Tregs) are being extensively investigated in ongoing clinical trials. However, these trials have been…
2018 American Transplant Congress
Improving the Organ Donation Referral Process through Telemedicine
M. Groveman,¹ M. Perry,² I. Berman,² N. Benavides,¹ A. Friedman.¹
¹LiveOnNY, NY; ²Northwell Health, New Hyde Park.
Development of a Tele-ICU serving multiple institutions within our donor service area stimulated a collaborative performance improvement project. To improve the referral and timeliness rates…
2018 American Transplant Congress
Role of B Cell Intrinsic NLRP3 in the Development of Chronic Rejection
J. Nie,¹ B. Ramaswami,² X. Guo,³ R. Hoffman,² G. Chalasani.³
¹Thoracic Surgery, Huazhong University of Science and Technology, Wuhan, Hubei, China; ²Surgery, Starzl Transplantation Institute, Pittsburgh, PA; ³Medicine, University of Pittsburgh, Pittsburgh, PA.
Endogenous DAMPs elicited during transplantation are recognized via TLR-MyD88 and NLRP3-inflammosome pathways that are expressed in APCs including B cells. Here, we asked whether B…
2018 American Transplant Congress
Intragraft MicroRNAs Foretell Fibrosis in Kidney Transplant Recipients
H. Yang,¹ L. Amrouche,² K. Akat,³ C. Li,¹ Z. Khan,¹ C. Tinel,² T. Tuschl,³ D. Anglicheau,² T. Muthukumar.¹
¹Weill Cornell Medicine, New York; ²Hôpital Necker, Paris, France; ³Rockefeller University, New York.
BackgroundIdentifying biomarkers that anticipate tubulointerstitial fibrosis (IFTA) of the kidney allograft will be a transformative advance.Aim/HypothesisIntragraft microRNA profile of 3-month surveillance biopsies reported as normal…
2018 American Transplant Congress
Clinical Significance and Therapeutic Potential of Orosomucoid 1 for Chronic Active Antibody Mediated Rejection in Kidney Transplant Recipients
H. Higuchi,^1,2 K. Hotta,¹ D. Iwami,¹ J-.J. Jiang,² D. Kamimura,² Y. Arima,² T. Atsumi,² Y. Takada,^1,2 H. Harada,³ M. Murakami,² N. Shinohara.¹
¹Department of Renal and Genitourinary Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; ²Division of Molecular Psychoimmunology, Institute for Genetic Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; ³Department of Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Hokkaido, Japan.
［Background］We reported a molecular mechanism to develop chronic inflammation (CI), called the inflammation amplifier (IA). IA is activated by concomitant activation of NFkB and STAT3…
2018 American Transplant Congress
Long-Term HIF-1α Stabilization is Associated with Fibrosis in Rat Lung Allografts
K. Freischlag,¹ B. Ezekian,¹ P. Schroder,¹ J. Everitt,¹ J. Yoon,¹ M. Swiderska-Syn,³ W. Parker,¹ A. Diehl,¹ J. Kwun,¹ S. Knechtle.¹
¹Duke Transplant Center, Duke University, Durham, NC; ²Medical University of South Carolina, Charleston, SC.
Introduction: HIF-1α is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) and functions as a master transcriptional regulator of cellular and developmental…