Am J Transplant, Volume 18, Suppl 3 Archives - Page 155 of 211 - ATC Abstracts

2018 American Transplant Congress
Hospitality Houses and Transplant Patients: Assessing the Impact of a Hospitality House Dedicated to Transplant Patients and Their Families
T. Giordano,¹ J. Campbell,² J. Weinstock,³ H. Nathan.³
¹Social Work, Gift of Life Family House, Philadelphia, PA; ²Campbell-Collaboratives, LLC, Ardmore, PA; ³Executive Leadership, Gift of Life Donor Program, Philadelphia, PA.
Hospitality houses exclusively for transplant patients and their families are a relatively new concept and their connection to medical outcomes is untested. One hospitality house…
2018 American Transplant Congress
ABO Tolerance after Treatment of Infant or Adult Mice with MHC-Matched A-Expressing Blood Cells
B. Motyka,¹ J. Fersovich,¹ B. Lamarche,¹ M. Sosniuk,¹ I. Adam,¹ J. Pearcey,¹ K. Tao,¹ C. Cairo,² P. Cowan,³ L. West.¹
¹Dept Pediatrics, Alberta Transplant Institute, Canadian National Transplant Research Program, University of Alberta, Edmonton, Canada; ²Dept Chemistry, University of Alberta, Edmonton, Canada; ³St Vincent's Hospital, Melbourne, Australia.
Purpose: ABO-incompatible heart transplantation (ABOi HTx) is safe during infancy and allows increased donor access. Post-ABOi HTx B cell tolerance develops to donor blood group…
2018 American Transplant Congress
TGF-b Plus Rapamycin Induce Foxp3 and Promote iTreg Development and Suppressive Function, Leading to Long-Term Allograft Survival
L. Wang, A. Samanta, R. Han, N. Zhou, W. Hancock.
Path & Lab Med, CHOP & UPenn, Philadelphia, PA.
Given the major roadblocks to development of Treg-based cell therapy, pharmacologic approaches to expand endogenous Tregs warrant attention, including approaches with more sustained effects than…
2018 American Transplant Congress
α-1 Antitrypsin Facilitate Apoptosis Donor Cells Inducing Donor Specific Protection to Mice Cardiac Allografts
G. Chen, X. Lai, L. Qiu, Y. Zhao, S. Yu, C. Wang, J. Zhang, F. Ning, L. Chen.
Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Previous study has shown that intravenous infusion of ethylene carbodiimide fixed donor splenocytes(ECDI-SPs) can induce tolerance of mice cardiac allografts with rapidly apoptosis of ECDI-SPs…
2018 American Transplant Congress
Genome-Wide Association Study of Tacrolimus Dose in Pediatric Solid Organ Transplant Recipients in the CNTRP POSITIVE Study
S. Min,¹ T. Papaz,¹ T. Blydt-Hansen,³ O. Lee,¹ U. Allen,¹ P. Birk,² H. Grasemann,¹ L. Hamiwka,⁴ C. Litalien,⁵ V. Ng,¹ R. Parekh,¹ K. Tinckam,⁶ S. Urschel,⁷ B. Foster,⁸ S. Mital.¹
¹The Hospital for Sick Children, Toronto, Canada; ²Winnipeg Children's Hospital, Winnipeg, Canada; ³BC Children's Hospital, Vancouver, Canada; ⁴Alberta Children's Hospital, Calgary, Canada; ⁵CHU Ste-Justine, Montreal, Canada; ⁶University Health Network, Toronto, Canada; ⁷Stollery Children's Hospital, Edmonton, Canada; ⁸Montreal Children's Hospital, Montreal, Canada.
PURPOSE: There are significant challenges in achieving therapeutic tacrolimus (Tac) concentrations after transplant. We explored variants associated with tacrolimus dose requirements in pediatric solid organ…
2018 American Transplant Congress
Primary Insult to the Native Lungs Are Needed for Antibodies to Lung Self-Antigens, Kα1Tubulin and Collagen V, to Be Pathogenic for the Development of Obliterate Airway Disease
M. Sharma, W. Liu, T. Mohanakumar.
Norton Thoracic Institute, St. Joseph's Hospital & Medical Center, Phoenix.
Introduction: Antibodies (Abs) to lung self-antigens (SAgs) have been correlated with development of bronchiolitis obliterans syndrome following human lung transplantation. Further, administration of Abs to…
2018 American Transplant Congress
Endothelin A Receptor (ETaR) siRNA Ameliorates Renal Ischemia Reperfusion Injury through Upregulating Expression of eNOS in Rats
Y. Jia, L. Li, T. Zhu.
Shanghai Key Labratory of Organ Transplantation, Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China.
Aims: To explore the protective effect of Endothelin A Receptor (ETaR) siRNA on renal ischemia reperfusion injury and its underlying mechanism.Methods: The model of unilateral…
2018 American Transplant Congress
Impact of Sleep Apnea Syndrome on Late Graft Dysfunction
A. Afzal,¹ K. Tecson,² A. Jamil,³ A. Wazir,¹ J. Felius,³ H. Qin,³ P. Garcha,¹ S. Carey,¹ S. Hall.¹
¹Center for Advanced Heart and Lung Disease, Baylor University Medical Center, Dallas, TX; ²Baylor Heart and Vascular Institute, Baylor Scott & White Research Institute, Dallas, TX; ³Annette C. and Harold C. Simmons Transplant Institute, Baylor Scott & White Research Institute, Dallas, TX.
Background: Sleep apnea syndrome (SAS) is associated with higher risk of stroke, cardiovascular events, arrhythmias, hypertension, and congestive heart failure. However, there is a paucity…
2018 American Transplant Congress
Institution-Based, Pharmacist-Managed Anticoagulation in Patients with a Left Ventricular Assist Device
T. Bibb,¹ L. Halder,¹ D. McDanel,¹ A. Briasoulis,² P. Alvarez,² K. Horner,¹ J. Bhama,³ S. Larson.³
¹Department of Pharmaceutical Care, University of Iowa Hospitals and Clinics, Iowa City, IA; ²Division of Cardiovascular Medicine, Department of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA; ³Division of Cardiothoracic Surgery, Department of Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA.
Long-term anticoagulation with warfarin is required for patients with left ventricular assist devices (LVADs). There is limited data of time in therapeutic range (TTR) in…
2018 American Transplant Congress
Extracellular Matrix from Pancreas Improves Human Islet Function In Vitro
Y. Shindo,¹ R. Pouillot,² B. Young,² P. Link,² R. Heise,² M. Levy,^1,3 M. Kanak.¹
¹Department of Surgery, School of Medicine, Virginia Commonwealth University, Richmond; ²Department of Biomedical Engineering, Virginia Commonwealth University, Richmond; ³Hume-Lee Transplant Center, VCU Health System, Richmond.
Background:Islets which are clinically transplanted into the portal vein are subjected to inflammatory insults in the peri-transplant period followed by immune assault causing long-term islet…