2018 American Transplant Congress
Is Kidney Transplantation Safe in Patients over 71 Years Old?
Department of Kidney & Liver Transplantation, ASUIUD, Udine, Italy.
Introduction: Kidney transplantation in elderly patients is superior over dialysis as therapy for end stage renal disease (ESRD). We analyzed different parameters to evaluate patient…2018 American Transplant Congress
An Effective Tolerance Approach for Porcine Islet Xenotransplantation in Humanized Mice
Purpose: Tolerance for pig-to-human islet transplantation could render a feasible and sustainable cure for T1D. We have previously described a triple therapy (TT) approach consisting…2018 American Transplant Congress
Transplant Hospitals Increase Volumes and Acceptance Rates under the COIIN Project
United Network for Organ Sharing, Richmond.
Introduction. Transplant center performance monitoring is based on one-year patient and graft survival. Through the OPTN contract with HRSA, UNOS created the Collaborative Innovation and…2018 American Transplant Congress
The THINKER Trial: Quality of Life Results at 6- and 12-Month Follow-Up among Hepatitis C-Negative Patients Who Received Kidney Transplants from Deceased Donors with Hepatitis C Infection
Univ of Pennsylvania, Philadelphia, PA.
Background: Short-term (6-month) data from the first 10 subjects in the pilot THINKER-1 trial (NCT02743897; funder: Merck) suggested that kidneys from HCV-infected donors could be…2018 American Transplant Congress
Molecular Profiling of the Injury-Repair Response in Early Subclinical Inflammation
UAB School of Medicine, Birmingham.
Purpose: Surveillance biopsies can detect subclinical T-cell mediated rejection (SC-TCMR) or subclinical borderline rejection (SC-B-TCMR) in kidney transplants with normal/stable creatinine. Some consider SC-B-TCMR to…2018 American Transplant Congress
Molecular Phenotypes of Injury and Rejection in Lung Transplant Transbronchial Biopsies
University of Alberta, Edmonton, Canada.
Purpose: Histologic assessment of lung transplant transbronchial biopsies (TBB) is not reproducible and cannot assess antibody-mediated rejection (ABMR). Molecular diagnostics (MMDx) successfully identified rejection in…2018 American Transplant Congress
hEPCR.hTBM.hCD47.HO-1 Contributes to Increased Survival, Reduced Platelet Sequestration, and Modulation of Coagulation Activation in GalTKO.hCD46 Porcine Livers Perfused with Human Blood
1University of Maryland School of Medicine, Baltimore, MD; 2Revivicor, Inc., Baltimore, MD.
IntroductionPlatelet sequestration and inappropriate coagulation cascade activation are associated with poor outcomes in multiple liver xenotransplant models. Here we evaluate a cassette of additional genetic…2018 American Transplant Congress
Redo Kidney Transplant in FSGS
Kidney and Pancreas Transplant Program, MedStar Georgetown Transplant Institute, Washington, DC.
Objective: Analyze risk of graft failure due to recurrent FSGS in patients with prior failed kidney transplants under consideration for a subsequent transplant.Results: We identified…2018 American Transplant Congress
Cannabis Dependence or Abuse before and after Kidney Transplantation: Implications for Post-Transplant Outcomes
Currently, transplant centers vary in screening practices for marijuana use and requirements for abstinence before kidney transplantationWe examined billing claims and linked SRTR data for…2018 American Transplant Congress
Metformin Use after Kidney Transplantation: A Safe Option in Carefully Selected Patients
Recent guidelines support metformin as a therapeutic option in diabetic patients with mild to moderate renal insufficiency. The frequency and outcomes of metformin use in…
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