Am J Transplant, Volume 18, Suppl 3 Archives - Page 140 of 211 - ATC Abstracts

2018 American Transplant Congress
Medication Adherence: Does Where You Live Matter?
S. Wadhwani,¹ S. Taylor,¹ C. Brokamp,¹ W. Guo,¹ E. Shemesh,² J. Bucuvalas.¹
¹Cincinnati Children's Hospital Medical Center, Cincinnati; ²Mount Sinai School of Medicine, New York.
Background & Objectives: Medication non-adherence remains problematic in pediatric liver transplant (LT)[mdash]estimates suggest that up to 53% of adolescents are non-adherent. We leveraged data from…
2018 American Transplant Congress
Transplantation Tolerance Prevents CMV Reactivation and Preserves Kidney Allograft Function in a D+/R- Transplant Setting
A. Dangi,¹ J-.J. Wang,² M. Burnette,¹ Z. Zhang,² X. Luo.^1,2
¹Division of Nephrology and Hypertension, Department of Medicine, Northwestern University, Chicago, IL; ²Comprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL.
Background: Immune responses to cytomegalovirus (CMV) infection may precipitate acute/chronic graft rejection in immunocompromised transplant recipients. CMV infection can be primary or its reactivation from…
2018 American Transplant Congress
Upregulated IL-33 in Heart Transplants Modulates Local Myeloid Populations to Protect against Chronic Allograft Rejection
Z. Zhang,¹ Q. Liu,¹ G. Hussey,² J. Dziki,² L. Mathews,¹ H. Dai,¹ G. Dwyer,^1,3 A. Lucas,¹ M. Oberbarnscheidt,¹ S. Badylak,² H. Turnquist.^1,3
¹University of Pittsburgh, Starzl Transplant Institute, Pittsburgh, PA; ²University of Pittsburgh, McGowan Institute for Regenerative Medicine, Pittsburgh, PA; ³Immunology, University of Pittsburgh, Pittsburgh, PA.
Purpose: Interleukin-33 (IL-33) is an “alarmin”, or a self-derived molecule that triggers pleotropic immune responses after release from damaged tissue. Yet, how IL-33 shapes alloresponses…
2018 American Transplant Congress
Multi-Organ (M-O) Prioritization of Kidneys: ? Time for Policy Modification
M. Aeder, N. Turgeon.
Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH; Surgery, Emory University, Atlanta, GA.
The revised Kidney Allocation System (KAS) has been operational for 3 years. The bolus effects seen early following the introduction have abated and a steady…
2018 American Transplant Congress
Frailty is Predictive of Early Post-Transplant Infection in Older Renal Transplant Recipients
M. Malinis,¹ C. Ogbejesi,² J. Luo,³ Y. Zhang,³ W. Asch,⁴ R. Deshpande,⁵ S. Akhtar.⁵
¹Section of Infectious Diseases, Yale School of Medicine, New Haven, CT; ²College of Medicine, Central Michigan University, Mount Pleasant, MI; ³Section of Surgical Outcomes and Epidemiology, Department of Surgery, Yale School of Medicine, New Haven, CT; ⁴Section of Nephrology, Yale School of Medicine, New Haven, CT; ⁵Department of Anesthesiology, Yale School of Medicine, New Haven, CT.
Background: Frailty is predictive of postoperative morbidity, including infections in older surgical patients. It is not known if frailty is associated with post-operative infections in…
2018 American Transplant Congress
Medullary Tissue Sampling in Renal Allograft Biopsy is More Sensitive for Pathologic Diagnosis of PVN
D. Abdelwahab,¹ H. Khamash,¹ S. Kriegshauser,³ R. Heilman,¹ M. Smith.²
¹Nephrology and Transplant, Mayo Clinic, Phoenix; ²Pathology and Laboratory Medicine, Mayo Clinic, Phoenix; ³Radiology, Mayo Clinic, Phoenix.
Background Post-transplant polyoma virus nephropathy (PVN) prevalence is 1-10%. Definitive PVN diagnosis requires polyoma virus presence in infected cells, done with immunohistochemical staining for SV40…
2018 American Transplant Congress
Broader Geographic Sharing and Impact on Lung Transplant Waitlist Time and Lung Allocation Score
W. Tsuang, M. Budev.
Cleveland Clinic, Cleveland.
Background: Donor lungs are preferentially offered to patients within a local geographic area before being offered to a broader region. This algorithm may prevent patients…
2018 American Transplant Congress
Lymph Node Stromal Laminins Affect Graft Survival through Regulation of CD4 T Cell Proliferation and Migration
L. Li, T. Simon, W. Piao, Y. Xiong, V. Saxena, T. Zhang, C. Wagner, J. Bromberg.
University of Maryland, Baltimore, MD.
Background: Our prior studies demonstrated that tolerance and immunity are associated with differential expression of lymph node (LN) stromal laminins α4β1γ1 (411) and α5β1γ1 (511),…
2018 American Transplant Congress
Genome Wide Non-HLA Alloimmunity Contributes to Graft Loss after Kidney Transplantation
R. Reindl-Schwaighofer, A. Heinzel, A. Kainz, K. Jelencsics, O. Viklicky, G. Böhmig, G. Fischer, B. Keating, R. Oberbauer.
Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria; Department of Nephrology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; Transplant Institute, University of Pennsylvania, Philadelphia, PA.
BackgroundChronic rejection is the main cause of renal transplant loss after the first year and has mostly been attributed to alloimmune responses against human leukocyte…
2018 American Transplant Congress
Efficacy and Safety of Bleselumab in Kidney Transplant Recipients: A Phase 2, Randomized, Open-Label Study
R. Harland,¹ G. Klintmalm,² S. Jensik,³ H. Yang,⁴ J. Bromberg,⁵ J. Holman,⁶ M. Anil Kumar,⁶ V. Santos,⁶ T. Larson,⁶ X. Wang.⁶
¹University of Arizona, Tucson; ²Annette C. and Harold C. Simmons Transplant Institute, Dallas; ³Rush University, Chicago; ⁴PinnacleHealth Transplant Associates, Harrisburg; ⁵University of Maryland, Baltimore; ⁶Astellas Pharma Global Development, Inc., Northbrook.
Introduction: Bleselumab (ASKP1240) is an anti-CD40 monoclonal antibody currently in development. This phase 2, randomized, open-label study assessed the efficacy and safety of bleselumab in…