2018 American Transplant Congress
Type-1 Interferon Impairs the Immunoregulatory Activity of IL-10: Understanding the Mechanisms of Abrogation of Transplant Tolerance
Plastic Surgery, Johns Hopkins UIniversity, Baltimore, MD.
A growing body of evidence shows that induction of long term transplant survival by costimulation blockade (CoB) regimens is impaired by inflammatory responses (e.g. engagement…2018 American Transplant Congress
Prolongation of Skin Allograft Survival through Dietary Supplementation of Ayrl Hydrocarbon Receptor Ligands
Transplant Surgery, University of Wisconsin, Madison, WI.
The Aryl Hydrocarbon Receptor (AHR) is a cytosolic transcription factor with numerous endogenous and xenobiotic ligands playing a key role in a number of cellular…2018 American Transplant Congress
Donor T Cells Undermine the Graft-Protective Effect of DST Plus Anti-CD154
Plastic Surgery, Johns Hopkins University, Baltimore, MD.
Costimulation blockade (CoB) regimens are a promising immunomodulatory strategy to prevent transplant rejection. However, their efficacy is affected by multiple factors, including still unknown ones.…2018 American Transplant Congress
Thymic Irradiation as a Maneuver for Repertoire Exchange in Costimulatory-Blockade-Based Immunotherapy
Background All successful, prospective clinical tolerance-induction strategies have employed thymic irradiation to achieve chimerism. However, evidence suggests durable chimerism is not required to attain tolerance.…2018 American Transplant Congress
Human Endothelial-Like Cells Transdifferentiated from Peripheral CD14+ Monocytes Inhibit T Cells in Response to Allo-Stimulation
Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.
We have previously demonstrated that the endothelial cells located in immune-privilege sites, such as livers, suppress T-cells in response to both of direct and indirect…2018 American Transplant Congress
Heart Transplant across Low or Moderate Level Donor-Specific Antibodies Have Acceptable Outcome
Cedars Sinai Medical Center, Los Angeles.
Purpose: The presence of pre-transplant donor specific antibodies (DSA) can reduce the likelihood of a patient (pt) obtaining a compatible donor heart. The proportion of…2018 American Transplant Congress
Cardiac MRI May Help to Determine When to Refer Heart Transplant Patients for Redo Heart Transplant
Cedars Sinai Medical Center, Los Angeles.
Purpose: Small vessel coronary artery disease is known to cause fibrosis. However, it is not clear whether myocardial fibrosis detected on MRI is associated with…2018 American Transplant Congress
Early Adjunctive Treatment with Human Cytomegaly Virus (CMV) Immunoglobulin Increased CMV-Free Survival after Heart Transplantation
Purpose: There is still an ongoing discussion whether a prophylactic or a preemptive therapy against cytomegalovirus (CMV) is superior to reduce the incidence of CMV…2018 American Transplant Congress
“I'll Be Back”: Increasing Readmission Rates in the Era of the New Kidney Allocation System
Background: National analysis of the impact of the new KAS has indicated an increase in DGF rates, total inpatient hospital costs & 30 day readmission…2018 American Transplant Congress
Sharing Works; Avoiding Kidney Transplantation to an Unintended Recipient by Precision Virtual Cross Match with Excellent Outcomes
1UCSF, San Francisco; 2Donor Network West, San Ramon.
Aim: It was recently estimated that 19.2% of imported kidneys go into an unintended recipient(UR), most commonly due to a positive crossmatch(AJT 2017, 17:2139) so…
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