2018 American Transplant Congress
Low Kidney Supply to Demand Ratio and Multi-Organ Transplant Centers Are Negatively Associated with Pediatric Renal Transplant Rates Post Kidney Allocation System Implementation: An Analysis of OPTN Data
Under the new kidney allocation system (KAS), pediatric (PED) renal (REN) transplant (Tx) candidates have priority to kidneys from donors with KDPI < 35%. We…2018 American Transplant Congress
Direct-Acting Antiviral Therapy Immune-Mediated Graft Dysfunction in Liver Transplant Recipients with Hepatitis C
Background and Aims:Interferon (IFN) treatment of hepatitis C virus (HCV) infection after liver transplantation (LT) can result in severe immune-mediated graft dysfunction (IGD). The occurrence…2018 American Transplant Congress
Basiliximab Induction in HIV-Positive Renal Transplant Recipients Compared to an HIV-Negative Cohort
Purpose: There is an elevated risk of acute rejection in HIV+ renal transplant recipients and continued evaluation of the most appropriate induction therapy remains. Use…2018 American Transplant Congress
Incidence of Epstein Barr Virus (EBV) DNAemia in EBV-Seronegative Solid Organ Transplant (SOT) Recipients with EBV-Seropositive Donors
Purpose: Since 2002, a pre-emptive approach to post-transplant lymhoproliferative disease prevention has been used at our center that includes EBV viral load (VL) monitoring in…2018 American Transplant Congress
Inhibition of IL-1R1 Signaling Delays Costimulation Blockade–Resistant Allograft Rejection by Preventing CD8 TEM Expansion
Department of Surgery, Emory University, Atlanta, GA.
The clinical utilization of Costimulaiton Blockade (CoB) led to improved long-term patient outcomes, but wider adoption of is hampered by increased rates of acute cellular…2018 American Transplant Congress
Prospective Analysis of EBV+ PTLD Incidence in Pediatric Transplant Recipients in the Modern Era
Post-transplant lymphoproliferative disorder (PTLD) remains a serious problem in the pediatric transplant population. The Clinical Trials of Organ Transplantation in Children (CTOTC)-06 is an NIAID-sponsored…2018 American Transplant Congress
Mechanisms of Vascularized Bone Marrow Graft Protection of Vascularized Composite Allografts
Surgery, University of Maryland, Baltimore, MD.
Background Co-transplantation of vascularized bone marrow (VBM) promotes vascularized composite allograft (VCA) survival with standard immunosuppression in a non-human primate (NHP) model. We investigated mechanisms…2018 American Transplant Congress
Endoplasmic Reticulum Stress Sensor IRE1α Deficiency Promotes Infiltrating Macrophage Polarization and Induces Long-Term Renal Allograft Acceptance in Mice
Objective: Macrophage is involved in the pathogenesis of I/R injury and allograft rejection. However, the mechanisms underlying this is vastly unknown. This study aims to…2018 American Transplant Congress
Effects of IdeS on HLA-SAB, C1q-SAB and CDC-XM
IgG degrading enzyme of Streptococcus pyogenes (IdeS) cleaves human IgG in two steps, first cleaving one of the heavy chains resulting in a single-cleaved IgG…2018 American Transplant Congress
New Onset Diabetes after Kidney Transplant: Comparisons of Risks Associated with Various Steroid-Containing Calcineurin Inhibitor and Sirolimus Regimens
INTRODUCTION: We aimed to examine the risk of new onset diabetes after transplant (NODAT) associated with the following maintenance immunosuppression regimens in kidney transplant recipients…
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