Am J Transplant, Volume 18, Suppl 3 Archives - Page 131 of 211 - ATC Abstracts

2018 American Transplant Congress
Medical Crowdfunding for Organ Transplant Patients
W. Durand,¹ J. Peters,¹ A. Eltorai,¹ S. Kalagara,¹ A. Osband,² A. Daniels.³
¹Alpert Medical School, Brown University, Providence, RI; ²Division of Transplant Surgery, Department of Surgery, Alpert Medical School, Brown University, Providence, RI; ³Division of Spine Surgery, Department of Orthopaedics, Alpert Medical School, Brown University, Providence, RI.
BACKGROUND: An increasing number of patients and families are utilizing online crowdfunding to support their medical expenses related to organ transplantation. The factors that influence…
2018 American Transplant Congress
PD-L1 May Serve as a Biomarker for Chimerism-Induced Tolerance in Kidney Transplant Recipients
A. Merchak,¹ A. Khalil,¹ A. Chhabra,¹ J. Leventhal,² S. Ildstad.¹
¹University of Louisville, Louisville, KY; ²Northwestern Memorial Hospital, Chicago, IL.
Durable chimerism is currently the most reliable biomarker of donor specific tolerance. Identifying and validating other predictive biomarkers is therefore a high priority. Since 2009…
2018 American Transplant Congress
Offspring Living Kidney Donors Should Not Be Ruled Out
X. Luo, A. Massie, C. Holscher, D. Segev.
Johns Hopkins University, Baltimore.
A recent study (AJT, January 2018) suggested that kidneys from offspring live donors conferred worse post-transplant outcomes than non-offspring live donors, and advocated selecting non-offspring…
2018 American Transplant Congress
Validation Study of Operational Tolerance Signatures in Korean Kidney Transplantation Recipients
J. Seo,¹ Y. Lee,¹ Y. Kim,¹ J. Moon,¹ K-.H. Jeong,¹ C-.D. Kim,² J. Park,³ B. Jeong,⁴ S-.H. Lee.¹
¹Department of Nephrology, School of Medicine, Kyung Hee University, Seoul, Korea; ²Department of Nephrology, Kyung-pook National University School of Medicine, Daegu, Korea; ³Department of Nephrology, Sungkyunkwan University, Samsung Hospital, College of Medicine, Seoul, Korea; ⁴Department of Nephrology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Background:A peripheral B cell population was significantly higher in drug-free operationally tolerant patients than those with stable graft function or acute rejection under standard immunosuppression.…
2018 American Transplant Congress
Assessment of Hepatic Ischemia-Reperfusion Injuries by NRF2-Dependent Transcriptional Activities of Bile Transporters in Rats
J. Kim,¹ A. Martin,¹ J. Yee,¹ L. Fojut,¹ A. Geurts,² K. Oshima,³ M. Zimmerman,¹ J. Hong.¹
¹Surgery, Medical College of Wisconsin, Milwaukee, WI; ²Physiology, Medical College of Wisconsin, Milwaukee, WI; ³Pathology, Johns Hopkins University School of Medicine, Baltimore, MD.
Background: The effect of hepatic ischemia and reperfusion injury (IRI) on bile transporter (BT) gene expression and the role of Nrf2 in BT regulation during…
2018 American Transplant Congress
Different Expression Patterns of Exosomal miRNAs under Cyclosporin A and Rapamycin Treatment in Distinct Aggressiveness Colorectal Carcinomas
V. Tubita,¹ M. Ramírez-Bajo,¹ J. Lozano,² D. Moya-Rull,¹ J. Rovira,³ J. Campistol,^4,5,6 F. Diekmann,^1,4,5,6 I. Revuelta.^1,4,5,6
¹Experimental Laboratory of Nefrology and Kidney Transplant (LENIT). Biomedical Research Clinic Foundation (FCRB), Barcelona, Spain; ²Bioinformatics Platform, CIBEREHD, Barcelona, Spain; ³Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; ⁴Renal Transplant Unit. Department of Nephrology and Kidney Transplant. Hospital Clinic, Barcelona, Spain; ⁵REDinREN, Madrid, Spain; ⁶Barcelona University, Barcelona, Spain.
The aggressiveness of colorectal cancer (CRC) in kidney transplantation is much more significant than the increase in its incidence compared with the general population. The…
2018 American Transplant Congress
Peptides Encoded by EBV Latent Cycle Proteins Affect NK Cell Reactivity
B. Mbiribindi, C. Romero Moreno, C. Esquivel, O. Martinez, S. Krams.
Department of Surgery, Stanford University School of Medicine, Stanford, CA.
Introduction: Epstein–Barr virus (EBV) infects more than 90% of adults worldwide and is associated with several malignancies, including post-transplant lymphoproliferative disorder (PTLD). Although EBV infection…
2018 American Transplant Congress
Gene Silencing with p53 si-RNA Downregulates Inflammatory Markers in the Liver: Potential Utilization during Normothermic Machine Preservation
C. Moore,¹ M. Thijssen,^1,2 X. Wang,³ P. Mandrekar,³ E. Xiaofei,³ R. Abdi,⁴ R. Porte,² A. Bozorgzadeh,¹ H. Leuvenink,² T. Kowalik,³ P. Martins.¹
¹Dept of Surgery, University of Massachusetts, Worcester, MA; ²Dept of Surgery, Groningen University, Gronigen, Netherlands; ³Dept of Medicine, Univ. of Massachusetts, Worcester, MA; ⁴Transplant Research Institute, Harvard University, Boston, MA.
Background: RNA interference (RNAi) is a process through which RNA induces the activation of endogenous cellular pathways of RNA degradation, resulting in selective and potent…
2018 American Transplant Congress
Defining Response to Standard of Care Treatment in Kidney Recipients with Antibody-Mediated Rejection: Role of C1q-Binding Donor-Specific Anti-HLA Antibodies
Y. Bouatou, D. Viglietti, O. Aubert, A. Loupy, C. Lefaucheur.
Paris Translational Research Center for Organ Transplantation, Paris, France.
A major hurdle to improving clinical care in kidney transplantation is the lack of biomarkers of the response to antibody-mediated rejection (ABMR) treatment. We investigated…
2018 American Transplant Congress
Comparison of Microvascular Inflammation in Renal Allograft Tissue between ABO Incompatible and ABO Compatible Kidney Transplantation
E. Ko,^1,2 B. Choi,^1,2 C. Park,^1,2 Y. Kim,^1,2 C. Yang,^1,2 B. Chung.^1,2
¹Transplant Research Center, College of Medicine, Seoul St.Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea; ²Division of Nephrology, Department of Internal Medicine, College of Medicine, Seoul St.Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
Background: Microvascular inflammation (MVI) is considered as a pathological marker for antibody-mediated rejection (AMR) in the presence of donor-specific antibody (DSA). We aimed to investigate…