Am J Transplant, Volume 18, Suppl 3 Archives - Page 123 of 211 - ATC Abstracts

2018 American Transplant Congress
Allogeneic T Follicular and T Conventional Responses Assessed by Proliferation, Cytokine Production, and TCR Clonality
C. Macedo,¹ M. Yamada,¹ X. Gu,¹ M. Suchoroski,² D. Hamm,² M. Kaplan,² D. Metes.¹
¹Thomas E. Starzl Transplantation Institute, Pittsburgh; ²Adaptive Biotechnologies, Seattle.
Background: Human CD4+ T cell allo-immunity plays pivotal roles during cellular and humoral allograft rejection. Our previous analysis showed that allo-reactive precursors were present in…
2018 American Transplant Congress
Trends in Liver Transplantation with Older Liver Donors in the United States
C. Haugen, X. Luo, A. Thomas, C. Holscher, J. Garonzik-Wang, M. McAdams-DeMarco, D. Segev.
Surgery, JHU, Baltimore.
As the US population ages, older liver donors (OLDs) represent a potential expansion of the donor pool. Historically, grafts from OLDs have been associated with…
2018 American Transplant Congress
Gut Microbiota Dysbiosis is an Independent Risk Factor for Development of Urinary Tract Infections in Kidney Transplantation
J. Lee,¹ A. Sholi,¹ C. Gong,¹ M. Magruder,¹ S. Albakry,¹ E. Edusei,¹ B. Botticelli,¹ D. Dadhania,¹ M. Lubetzky,¹ Y. Taur,² L. Ling,² E. Pamer,² M. Suthanthiran.¹
¹Weill Cornell, NY, NY; ²Memorial Sloan Kettering, NY, NY.
INTRODUCTION. We examine the relationship between the gut microbiota and development of Escherichia and Enterococcus urinary tract infections (UTIs).METHODS. We recruited 170 kidney transplant recipients…
2018 American Transplant Congress
Validating Molecular Microscope Readings and Estimating Agreement with Histology
P. Halloran, J. Reeve, The INTERCOMEX Study Group.
ATAGC, Edmonton, Canada.
We previously described a microarray diagnostic system (MMDx) for rejection in 1208 kidney transplant biopsies (J. Reeve et al. JCI Insight 2 (12), 2017). The…
2018 American Transplant Congress
Donation after Circulatory Death Donor Liver Transplantation without Ischemic Cholangiopathy: Is It Time to Expand DCD Liver Donor Pool?
C. Kubal,¹ P. Mihaylov,^1,2 B. Ekser,¹ A. Cabrales,¹ J. Fridell,¹ R. Mangus.¹
¹Transplant Surgery, Indiana University, Indianapolis; ²Division of General Surgery, IRCCS Policlinico San Matteo Foundation, University of Pavia, Lombardy, Italy.
Background: To prevent ischemic cholangiopathy (IC) after liver transplantation (LT), a protocol optimizing peri-operative conditions along with thrombolytic (tissue plasminogen activator) donor flush during DCD…
2018 American Transplant Congress
Ablation of Both mTOR and STAT3 in T Cells Induces Heart Transplant Acceptance in Donor Skin-Sensitized Mice
A. Xie,^1,2 W. Chen.^2,3
¹Division of Cardiothoracic and Vascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; ²Center for Immunobiology and Transplantation Research, Houston Methodist Research Institute, Houston, TX; ³Department of Surgery, Weill Cornell Medical College of Cornell University, New York, NY.
Allogeneic memory T cell response precludes the induction of transplant acceptance; how this process is regulated at the molecular level remains unclear. Both mTOR and…
2018 American Transplant Congress
PGE2/Beta-Catenin/XBP1 Signaling Controls Mesenchymal Stem Cell-Mediated Immune Regulation in Liver Ischemia and Reperfusion Injury
C. Li, S. Yue, L. Jiang, Q. Zhu, D. Farmer, R. Busuttil, J. Kupiec-Weglinski, B. Ke.
The Dumont-UCLA Transplant Center, Department of Surgery, Los Angeles, CA.
Background: Mesenchymal stem cells (MSCs) display profound immunomodulatory properties and tissue repairing capability under inflammatory conditions. However, it is unknown how MSCs may affect immunity…
2018 American Transplant Congress
Increasing the Donor Pool for Highly Sensitized Patients with Allele Specific Antibodies: Optimizing the Virtual Crossmatch (vXM)
A. Zhang,¹ Z. Zaky,² J. Africa,³ D. Good,¹ R. Bray,⁴ H. Gebel.⁴
¹Allogen Laboratories, Cleveland Clinic, Cleveland; ²Glickman Urological & Kidney Institute, Cleveland Clinic, Cleveland; ³Transplant Surgery, Charleston Area Medical Center, Charleston; ⁴Pathology & Laboratory Medicine, Emory University, Atlanta.
Background:Since implementation of the current Kidney Allocation System, highly sensitized patients with 98-100% cPRA (HSPs) are receiving ~10% of deceased donor kidneys compared to <2%…
2018 American Transplant Congress
The Living Donor Lost Wages Trial: Study Rationale, Protocol, and Update
J. Rodrigue,¹ M. Pavlakis,¹ A. Evenson,¹ A. Fleishman,¹ M. Carroll,¹ D. Mandelbrot,² P. Baliga,³ D. Howard,⁴ J. Schold.⁵
¹Beth Israel Deaconess Medical Center, Boston, MA; ²University of Wisconsin, Madison, WI; ³Medical University of South Carolina, Charleston, SC; ⁴Emory University, Atlanta, GA; ⁵Cleveland Clinic, Cleveland, OH.
Living donor kidney transplantation (LDKT) is the optimal treatment for adults with renal failure. However, living kidney donation has declined in the past decade, particularly…
2018 American Transplant Congress
Long-Term Medical, Financial, Psychosocial, and Overall Health-Related Quality of Life after Living Donation in Liver Transplantation
J. Emamaullee,¹ L. Sher,¹ T-.L. Fong,² K. Dhanireddy,¹ S. Zielsdorf,¹ C. Romero,¹ N. Wade,¹ Y. Genyk.¹
¹Surgery, University of Southern California, Los Angeles, CA; ²Keck School of Medicine at the University of Southern California, Los Angeles, CA.
Background: The long-term impact of living donation (LD) in liver transplantation on health-related quality of life (HRQOL) has not been well characterized. This study was…