Am J Transplant, Volume 18, Suppl 3 Archives - Page 119 of 211 - ATC Abstracts

2018 American Transplant Congress
Polyclonal Cellular Immune Function is Dose-Dependently Inhibited by Immunosuppressive Drugs but Has Limited Value in Predicting Infection or Rejection Episodes
S. Marx,¹ C. Adam,² S. Leyking,² U. Sester,² M. Sester.
¹Saarland University, Homburg/Saar, Germany; ²Saarland University, Homburg/Saar, Germany.
Background: Dosage of immunosuppressive drugs in transplant patients must be balanced to prevent graft rejection and infectious complications. Knowledge on general immune function may therefore…
2018 American Transplant Congress
Ultra Low Dose of IL-2 Produces Long-Term Drug-Free Survival of Cynomolgus Islets Allografts
M. Koulmanda,¹ V. Chipashivili,¹ L. Li,¹ M. Duggan,² T. Strom.¹
¹Medicine and Surgery, Beth Israel Deaconess Medical Center, Boston, MA; ²Surgery, MGH, Boston, MA.
Therapeutic principles established in non-human transplant models have value for clinical application despite cost related limitations on sample size. We have tested new therapies in…
2018 American Transplant Congress
Impact of the New Kidney Allocation System A2/A2B –> B Policy on Access to Transplantation among Minority Candidates
M. Mustian,¹ P. Martins,² P. MacLennan,¹ J. Ortiz,² J. Caicedo,² S. Gray,^1,2 B. Kelly,² C. Esquivel,² ASTS Diversity Affairs Commmittee,² J. Locke.^1,2
¹University of Alabama at Birmingham, Birmingham; ²ASTS Diversity Affairs Committee, Arlington.
Introduction: Blood group B kidney transplant candidates, many of whom represent ethnic minorities, have historically had diminished access to deceased donor kidney transplantation (DDKT). However,…
2018 American Transplant Congress
Impacts of HBsAg Seropositive Status on Patient and Graft Survival after Kidney Transplantation in the Era of New Antiviral Therapy: A Meta-Analysis
N. Leeaphorn,¹ C. Thongprayoon,² K. Sharma,² A. Sakhuja,³ W. Cheungpasitporn.⁴
¹Transplant Institute, Beth Israel Deaconess Medical Center, Boston, MA; ²Department of Medicine, Bassett Medical Center, Cooperstown, NY; ³Department of Medicine, Mayo Clinic, Rochester, MN; ⁴Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS.
BACKGROUND: An association between HBsAg seropositive status and increased mortality after kidney transplantation has been demonstrated in previous studies over the past decade. Although chronic…
2018 American Transplant Congress
Donor-Specific B-Cell Tolerance after Successful ABO Blood Type Incompatible (ABOi) Living Donor Liver Transplantation (LDLT)
T-.J. Wu, Y-.C. Wang, C-.H. Cheng, T-.H. Wu, C-.F. Lee, H. Chou, K-.M. Chan, W-.C. Lee.
Division of Liver and Transplantation Surgery, Department of General Surgery, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
Background/purposeABO blood type-incompatible (ABOi) liver transplantation is one of the strategies employed to overcome the shortage of donor. By using the Rituximab and plasm exchange,…
2018 American Transplant Congress
Increase in Potentially Resistant Non-Aspergillus Molds Isolated in Lung Transplant Recipients after Voriconazole and Posaconazole Prophylaxis
M. Fung,¹ J. Greenland,^2,3 S. Hays,² J. Singer,² J. Golden,² P. Chin-Hong.¹
¹Infectious Diseases, University of California San Francisco, San Francisco, CA; ²Pulmonary and Critical Care, University of California San Francisco, San Francisco, CA.
Background: Lung transplant recipients are at higher risk for invasive fungal infections compared to other solid organs transplant patients. Antifungal prophylaxis with mold-active azoles has…
2018 American Transplant Congress
Genetically Modified Porcine Erythrocytes: A Cell Model for Studying Human Preformed Antibody-Dependent Xenoimmune Responses In Vitro
Z. Wang, G. Martens, J. Ladowski, M. Tector, A. Tector.
Surgery, University of Alabama at Birmingham, Birmingham, AL.
Background: Powerful gene editing technology is a promising approach to provide genetically-modified pigs as donors for clinical cell, tissue and organ xenotransplantation. Prior to starting…
2018 American Transplant Congress
Transplanting Kidneys from HCV-Infected Donors into HCV-Negative Recipients: Longer-Term and Extended Results of the THINKER Trial
D. Goldberg,¹ E. Blumberg,¹ P. Abt,¹ M. Levine,¹ P. Porrett,¹ A. Naji,¹ S. Nazarian,¹ D. Sawinski,¹ J. Trofe-Clark,¹ V. Van Deerlin,¹ C. Gentile,¹ J. Smith,¹ M. Kaminski,¹ A. Sicilia,¹ R. Hasz,² L. Suplee,² R. Reddy,¹ R. Bloom,¹ P. Reese.¹
¹University of Pennsylvania, Philadelphia; ²Gift of Life, Philadelphia.
Background: In 2016, 800 kidneys from HCV+ deceased donors were discarded. Short-term (6-month) data from the first 10 subjects in the THINKER-1 trial (NCT02743897; funder:…
2018 American Transplant Congress
Outcome Implications of Benzodiazepines and Opioid Co-Prescriptions before Kidney Transplantation
N. Lam,¹ M. Schnitzler,² D. Axelrod,³ V. Dharnidharka,⁴ D. Segev,⁵ A. Naik,⁶ H. Xiao,² R. Ouseph,² H. Randall,² G. Hess,⁷ B. Kasiske,⁸ D. Brennan,⁵ T. Alhamad,⁴ K. Lentine.²
¹Univ Alberta, Edmonton, Canada; ²Saint Louis Univ, St. Louis; ³Lahey Clinic, Burlington; ⁴Washington Univ, St. Louis; ⁵Johns Hopkins, Baltimore; ⁶Univ Michigan, Ann Arbor; ⁷Hennepin, Minneapolis; ⁸Symphony Health, Conshohocken.
Recent studies have identified co-prescription of benzodiazepines and opioids as a risk factor for adverse outcomes in the general population. We previously described associations of…
2018 American Transplant Congress
ACEI/ARB Use within One Year of Kidney Transplant is Associated with Less AKI and Graft Loss in Older Recipients
M. Posadas Salas, R. Rodriguez, P. Amaechi, V. Rao, D. Taber.
Medical University of South Carolina, Charleston, SC.
As short-term outcomes have improved, optimizing long-term graft survival remains a major focus of transplant programs. Older kidney transplant recipients are particularly vulnerable to acute…