2018 American Transplant Congress
Rituximab Interference in B-Cell Crossmatch: A Problem Solved
Background: Rituximab is commonly prescribed in ABO- or HLA-incompatible kidney transplantation. When used before transplant it interferes with B lymphocyte complement-dependent crossmatch (CDC CM) or…2018 American Transplant Congress
A 3C Approach Drives Epigenetic Fixation of Foxp3 Expression and Stabilizes Treg Cell Lineage and Therapeutic Function
Immunobiology & Transplant Research Center, Houston Methodist Hospital, Houston, TX.
The instability of the regulatory T (Treg) cell lineage precludes their therapeutic potential in transplantation and autoimmune diseases. Herein, we invented a novel approach to…2018 American Transplant Congress
Cost Impacts of Alternative Kidney Transplant Immunosuppression: A National Cohort Study
Economic outcomes are increasingly considered along with clinical efficacy to guide choice of alternative therapies. We examined the cost impact of kidney transplant (KTx) induction…2018 American Transplant Congress
Long Term Histologic Allograft Health is Preserved Despite Rejection during Protocolized Immunosuppression Withdrawal (ISW) in Stable Pediatric Liver Transplant Recipients
Background: Long term allograft health after rejection during ISW has not been previously assessed. We compare baseline and 4yr graft histology of 20 rejectors in…2018 American Transplant Congress
Longitudinal Molecular Assessment of Renal Allograft and Short-Term Outcome: Markers of Injury and Recovery
1Surgery, UVA, Charlottesville; 2NWU, Chicago.
Background: Ischemia reperfusion (I/R) is influenced by both donor and recipient characteristics and affects early graft function and the recovery process. To understand underlying mechanisms…2018 American Transplant Congress
Primary Cytomegalovirus Infection in Seronegative Kidney Transplant Patients is Associated with Prolonged Cold Ischemic Time of Seropositive Donor Organs
Introduction: Human Cytomegalovirus (CMV) infection is still a major risk factor for immunocompromised patients, e.g. kidney recipients. Based on the CMV serostatus of donor (D)…2018 American Transplant Congress
Circulating Wnt Pathway Factors Are Non-Invasive Biomarkers of Transplant Vascular Injury
Purpose: Transplant vascular injury (TVI) is a major cause of renal allograft failure and is resistant to treatment. Non-invasive pathogenic biomarkers of TVI would provide…2018 American Transplant Congress
What's Normal? An Evaluation of Pediatric T Cell Markers in Healthy Controls
INTRODUCTION: Studying pediatric patients includes challenges such as difficulty obtaining samples, limited normal controls and small volumes. Standardized flow cytometry (FC) lymphocyte immunophenotyping panels are…2018 American Transplant Congress
Hyperglycemia Aggravates Hepatic Ischemia and Reperfusion Injury by Inhibiting Liver Resident Macrophage M2 Polarization via C/EBP-Homologous Protein-Mediated Endoplasmic Reticulum Stress
Anesthesiology, First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Background:Aggravated liver ischemia and reperfusion (IR) injury has been observed in hyperglycemic hosts, but its underlying mechanism remains undefined. The aim of the study was…2018 American Transplant Congress
Significant Difference between Proteasome and Immunoproteasome Inhibition in Acute Kidney Injury
The proteasome inhibitor bortezomib has successful administrated in kidney transplant recipients with acute or chronic antibody-mediated rejection, but there were some unfavorable cases which arised…
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