Am J Transplant, Volume 17, Suppl 3 Archives - Page 91 of 181 - ATC Abstracts

2017 American Transplant Congress
Impact of Peri-Transplant Viral Upper Respiratory Infection on Pediatric Liver Transplant Outcomes.
J. Kohler,¹ T. Miloh,¹ K. Hosek,¹ J. Goss,² F. Munoz.¹
¹Pediatrics, Baylor College of Medicine, Houston, TX; ²Surgery, Texas Children's Hospital, Houston, TX
BACKGROUND: Viral upper respiratory infection (vURI) is common in children and its effect at the time of liver transplant (LT) on the post-operative outcomes is…
2017 American Transplant Congress
Clinical Significance of Alloantibodies in Hand Transplantation: Impact on Rejection and Functional Outcome.
E. Berglund,¹ M. Andersen Ljungdahl,¹ D. Bogdanovic,¹ D. Berglund,³ J. Wadström,¹ A. Weissenbacher,² P. Petruzzo,⁴ S. Schneeberger.²
¹Karolinsk Institutet, Dpt of Clinical Science, Intervention, and Technology, Stockholm, Sweden; ²Innsbruck Medical University, Center for Operative Medicine, Innsbruck, Austria; ³Uppsala University, Dpt of Immunology, Genetics and Pathology, Section of Clinical Immunology, Uppsala, Sweden; ⁴Edouard Herriot Hospital, Dpt of Transplantation, Lyon, France
Purpose: Although alloantibodies, and donor-specific antibodies (DSA) in particular, are well-known to negatively impact graft survival in human solid organ transplantation, little is known about…
2017 American Transplant Congress
Accelerated Rejection of Secondary Third Party Allografts in Older Recipients Is Facilitated by an Augmented Innate Immune Response.
T. Heinbokel, K. Minami, A. Elkhal, S. Tullius.
Transplant Surgery Research Laboratory and Division of Transplant Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Accumulating evidence acknowledges the central relevance of aging and chronic antigen exposure in shaping the balance of innate and adaptive immunity. Here, we assessed whether…
2017 American Transplant Congress
Ambulatory Antibiotic Utilization and Outcomes in an Adult Kidney Transplant Population: A Pharmacovigilance Analysis.
L. Avery, C. Fominaya, R. Crawford, D. Taber.
Pharmacy, Ralph H Johnson VAMC, Charleston, SC
Antibiotics (abx) are commonly prescribed to kidney transplant (KTX) recipients in the outpatient setting. There is limited data assessing the safety and outcomes associated with…
2017 American Transplant Congress
Use of Ledipasvir/Sofosbuvir with or without Ribavirin in Patients Post-Liver Transplant: Evaluation of Real-World Datasets.
S. Flamm,¹ M. Charlton,² M. Manns,³ M. Prieto,⁴ I. Fernandez,⁵ M. Londono,⁶ R. Kwok,⁷ C. Smith,⁸ S. Lee,⁹ H. Ngo,⁹ A. Osinusi,⁹ A. Copans,⁹ L. Rossaro,⁹ M. Shoreibah,¹⁰ O. Massoud,¹⁰ M. Curry,¹¹ M. Bourliere.¹²
¹Northwestern University, Chicago; ²Intermountain Medical Center, Murray; ³Hannover Medical School, Hannover, Germany; ⁴Hospital Universitari I Politecnic La Fe, Valencia, Spain; ⁵Hospital Universitario 12 de Octubre, Madrid, Spain; ⁶Servicio de Hepatología. Hospital Clinic, Barcelona, Spain; ⁷Walter Reed National Military Medical Center, DC; ⁸Medstar Georgetown University Hospital, Georgetown; ⁹Gilead Sciences, Inc., Foster City; ¹⁰University of Alabama Birmingham, Birmingham; ¹¹Beth Israel Deaconess Medical Center, Boston; ¹²Hospital Saint Joseph, Marsielle, France
PURPOSE: Post-liver transplant(LT) patients with HCV are considered a difficult-to-treat population. Ledipasvir/sofosbuvir(LDV/SOF) +ribavirin(RBV) for 12 weeks is approved in GT1 LT recipients based on the…
2017 American Transplant Congress
Transplantation of Organs from Donors with Hepatitis C: The Potential to Substantially Increase Transplant Activity.
P. Trotter,^1,2 M. Robb,² I. Ushiro-Lumb,² J. Powell,³ C. Watson,¹ J. Bradley,¹ J. Neuberger.^2,4
¹Department of Surgery, University of Cambridge, Cambridge, United Kingdom; ²Organ Donation and Transplantation, National Health Service Blood and Transplant, Bristol, United Kingdom; ³Hepatic-Pancreatico-Biliary Surgical Services and Edinburgh Transplant Unit, Royal Infirmary Edinburgh, Edinburgh, United Kingdom; ⁴The Liver Unit, Queen Elizabeth Hospital, Birmingham, United Kingdom
Introduction. Organs from hepatitis C virus positive (HCV+ve) donors are commonly declined for transplantation because of the risk of disease transmission, but new direct acting…
2017 American Transplant Congress
Assessment of the Association Between Measures of Metabolic Function and Pancreas Graft Survival.
S. Mittal,¹ R. Franklin,² J. Levy,² S. Gough,² E. Sharples,¹ P. Friend.¹
¹Department of Renal Transplantation, Oxford Transplant Centre, Oxford, United Kingdom; ²Department of Diabetology, Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford, United Kingdom
Introduction: The lack of a validated measure of graft function after pancreas implantation has hindered our ability to monitor recipients post-transplant and identify declines in…
2017 American Transplant Congress
TIM-3 – CEACAM1 Checkpoint Regulation of T-Cell Activation and Hepatocellular Function in Liver Transplantation.
K. Nakamura,¹ S. Kageyama,¹ M. Kujawski,³ R. Sosa,² E. Reed,² A. Zarrinpar,¹ R. Busuttil,¹ J. Kupiec-Weglinski.¹
¹Dept. Surgery, UCLA, Los Angeles, CA; ²Dept. Pathology, UCLA, Los Angeles, CA; ³Dept. Molecular Immunology, City of Hope, Duarte, CA
Background/Aim: We have documented crucial role of TIM-3 dependent T cell dysfunction in mouse orthotopic liver transplantation (OLT). CEACAM1 (CD66a; CM1; Carcinoembryonic Antigen-Related Cell Adhesion…
2017 American Transplant Congress
Successful Induction of Tolerance of Fully Allogeneic Lung Graft with Adenosine A_2A Receptor (A2AR) Agonist in MHC-Defined CLAWN Miniature Swine.
H. Sahara, M. Sekijima, T. Murokawa, Y. Ariyoshi, T. Iwanaga, Y. Ichinari, A. Shimizu, K. Yamada.
Center for Advanced Biomedical Science and Swine Research, Kagoshima University, Kagoshima, Japan
Introduction: A2AR agonist is known to potently attenuate lung ischemia-reperfusion injury. However, the long-term effects of A2AR agonist on lung allograft survival remain unclear especially…
2017 American Transplant Congress
Antibodies to Angiotensin Type II Receptor I Are Associated with Primary Graft Dysfunction After Orthotopic Heart Transplant in Patients with Ventricular Assist Device as Bridge to Transplant.
M. Hickey,¹ E. DePasquale,² S. Shah,³ D. Vucicevic,² J. Zhang,¹ N. Valenzuela,¹ M. Deng,² E. Reed.¹
¹UCLA Immunogenetics Center, Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA; ²UCLA Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA; ³UCLA David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA
Primary graft dysfunction (PGD) following orthotopic heart transplant (OHT) is one of the leading causes of posttransplant mortality. We hypothesized that antibody to angiotensin type…