2017 American Transplant Congress
Significance of Atypical Cytology in the Evaluation of Patients with End Stage Renal Disease for Transplantation.
Urology, Western University, London, ON, Canada
INTRODUCTION AND OBJECTIVES: Renal transplantation is the most optimal method of treating patients with end-stage renal disease (ESRD). As part of their routine malignancy screening,…2017 American Transplant Congress
Loss of Bat3 Could Promote Transplant Tolerance by Regulating CD4 + T Cells Function.
Objective: To explore the effect of Bat3 on T cells and its function in transplant tolerance inductionMethodsWe generated Bat3flox/flox CD4-Cre + mice, sorted WT and…2017 American Transplant Congress
Heat Shock Protein 90 Inhibitor, 17DMAG Suppresses Acute Allograft Rejection and Prolongs Allograft Survival in Solid Organ Transplantation.
Urology, Sapporo Medical University School of Medicine, Sapporo, Japan
Purpose: Heat shock protein 90 (HSP90) is a ubiquitously expressed molecular chaperone that is associated with the correct activation of client proteins. Important roles of…2017 American Transplant Congress
IP-10 Monoclonal Antibody Treatment Suppresses Inflammatory Components of IBMIR and Improves Pancreatic Islet Graft Function.
Introduction: An instant blood-mediated inflammatory response (IBMIR) causes acute loss of pancreatic islets. Interferon gamma-induced protein 10 (IP-10) is a key proinflammatory chemokine that may…2017 American Transplant Congress
Novel Biomarkers for Segregating Lung Transplant Rejection Phenotypes.
We sought to investigate biomarkers in BAL fluid and tissue for segregating BOS and RAS chronic rejection phenotypes in lung allografts. We had previously identified…2017 American Transplant Congress
Urine Biomarkers (UBio) Correlate Poorly with Pre-Liver Transplant (LT) Kidney Biopsy Findings and Post-LT Kidney Function.
UBio might be valuable in determining the etiology of renal dysfunction in LT candidates.Aim: Correlate UBio with pre-LT kidney biopsy and post-LT kidney function.Methods:78 LT…2017 American Transplant Congress
Human IL-10 Transfection of Porcine Lungs Significantly Increases IL-10 Levels in Vascular Perfusate During Human Blood Perfusion.
PurposePorcine organs are a potential source for clinical xenotransplantation. Pig lungs perfused with human blood exhibit inflammation and loss of vascular barrier function within hours.…2017 American Transplant Congress
Focal Segmental Glomerulosclerosis Recurrence in Renal Transplant Recipients Treated with Belatacept.
Emory Transplant Center, Atlanta, GA
Introduction: Focal segmental glomerulosclerosis (FSGS) is a cause of end-stage renal failure that frequently recurs following renal transplant, often leading to allograft loss. A recently…2017 American Transplant Congress
Comparison of Long Term Renal Function Outcomes for Everolimus (EVR) vs. Sirolimus (SIR) vs. Mycophenolate Acid (MPA) Immunosuppressive Regimens Post Kidney Transplant (Ktx).
MPA or mammalian target of rapamycin inhibitors (mTORi [EVR or SIR]) in combination with calcineurin inhibitors (CNI, tacrolimus [TAC] or cyclosporine) are used for maintenance…2017 American Transplant Congress
A Critical Analysis of Equations for MPA Exposure in Patients Under EC-MPS and Tacrolimus.
Hospital das Clinicas FMUSP, Sao Paulo, Brazil
Mycophenolic acid(MPA) PK, from enteric-coated mycophenolate sodium(EC-MPS) has a broad range of Tmax avoiding the use a single concentration to calculate the area-under-the-time-concentration curve(AUC). Either…
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