2017 American Transplant Congress
PTEN Inhibition in MSC Upregulates PD-L1 and Enhances Their Immunomodulatory Capacity Prolonging Skin Allograft Survival.
Brigham and Women's Hospital, Boston, MA
Due to lack of autologous and donor site morbidity, there is a distinct clinical need to increase the utility of skin allografts by improving their…2017 American Transplant Congress
Effect of Induction Therapy in ABO Incompatible Living-Donor Kidney Transplantation: A Single Center Experience.
Department of Nephrology and Organ Transplantation, Toulouse University Hospital, Toulouse, France
Due to the shortage in organs, ABO incompatible (ABOi) living-donor kidney transplantation (LDKT) was developed. Herein, we report on our single center experience and assess…2017 American Transplant Congress
A New Strategy for Loco-Regional Therapy of Hepatocellular Carcinoma: Stereotactic Body Radiotherapy as a Bridge to Liver Transplantation.
Background: Transarterial chemoembolization (TACE) or radiofrequency ablation are often used as local Hepatocellular Carcinoma (HCC) treatment while waiting for a liver transplant (LTx). However, it…2017 American Transplant Congress
The American Transplant Congress Effect on Kidney Discard Rates in the United States.
1Mayo Clinic, Scottsdale, AZ; 2University of Utah, Salt Lake City, UT
Background: Deceased-donor kidneys with high kidney donor risk index (KDRI) are often discarded despite evidence that certain candidates would have better survival accepting these kidneys…2017 American Transplant Congress
KDPI Usefulness in Spain: A Comparison with Classical ECD/SCD.
Kidney donor shortage requires an expansion in selection criteria and objective tools to minimize discarded organs. Easy donor pretx variables such as age, standard/expanded criteria…2017 American Transplant Congress
Identification of NKG2D as Senescence Marker in Zero-Hour Kidney Biopsies Is Indicative for Clinical Outcome.
The definition of biological donor organ age rather than chronological age seems an obvious factor for the establishment of valid pre-transplant risk assessment. We therefore…2017 American Transplant Congress
Kidney-Specific Immunosuppression without Adverse Systemic Effects.
Purpose: Immunosuppressive therapy is often accompanied by severe adverse effects. To overcome this, the aim of this study was the evaluation of a kidney-specific drug…2017 American Transplant Congress
CD4 T Cell Depletion Mitigates Ischemic Hepatocellular Damage and Promotes Immune Regulation in Mouse Liver Allografts.
Background: Extended cold preservation contributes to organ ischemia-reperfusion injury (IRI), which stimulates host allo-reactivity, leading to inferior clinical outcomes. We have shown that CD4+ T…2017 American Transplant Congress
Succinate Accumulation During Warm and Cold Ischemia in Mouse, Pig and Man: Mechanistic and Therapeutic Implications for Transplant Ischemia-Reperfusion Injury.
Introduction: The burst of reactive oxygen species associated with ischemia-reperfusion (IR) injury is mediated through a specific metabolic pathway involving mitochondrial accumulation of the metabolite…2017 American Transplant Congress
Transcriptomic Analysis Revealed a Fibrotic Role of Epithelial Cells Originated from the Recipient in Kidney Transplant.
Renal fibrosis is one of major causes for chronic renal dysfunction in kidney diseases and graft loss in kidney transplant. With an aim to better…
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