2017 American Transplant Congress
FcγRIIB-Mediated Coinhibition Attenuates Donor-Reactive CD8+ T Cell Responses.
Emory Transplant Center, Emory University, Atlanta, GA
Memory T cells can be a formidable barrier to long-term, rejection-free allograft survival, particularly in the setting of costimulation blockade. Ongoing work in the field…2017 American Transplant Congress
Retrospective Analysis of Multiple Hemodialysis Access Modalities.
1Tampa General Hospital, Tampa, FL; 2University of South Florida, Tampa, FL
The use of native arteriovenous fistulas (AVF) for hemodialysis (HD) is the gold standard, however, for many patients, this is not an option. We hypothesize…2017 American Transplant Congress
Donor-Derived Cell-Free DNA Predicts Biopsy-Proven Acute Cellular Rejection in Pediatric Kidney Transplant Recipients.
1Surgery, Stanford University, Palo Alto, CA; 2CareDx, Brisbane, CA
Introduction: Surveillance of allograft health is a critical component of post-kidney transplant care. Invasive protocol biopsies are associated with secondary complications and often provide results…2017 American Transplant Congress
Dialysis Facility Providers' Awareness of Racial Disparities in Kidney Transplantation.
Background Racial disparities persist in access to kidney transplant (KTx) in the US, where African Americans (AAs) have lower rates of waitlisting than whites. Despite…2017 American Transplant Congress
Inhibition of Liver Natural Killer Cells Activation Through Co-Transplantation of Pre-Activated Mesenchymal Stem Cells Contributes to Improvement of Islet Graft Survival.
Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan
Introduction: We have previously reported that enhancement of TNF-related apoptosis-inducing ligand (TRAIL)-mediated liver NK-cell activity after intraportal islet transplantation (IT) inhibits engraftment of islets. Recently,…2017 American Transplant Congress
Immune Sensitization During Pregnancy Reduces Long-Term Benefit for Kidney Recipients of Offspring Living Donors.
Background Offspring-to-mother kidney transplantations are associated with excellent short-term outcomes given the accuracy of histocompatibility testing and potency of immunosuppression. However, immunologic memory responses in…2017 American Transplant Congress
The mTOR Signal Regulates Myeloid Derived Suppressor Cells Differentiation and Immunosuppressive Function in Acute Kidney Injury.
Urology, Zhongshan Hospital, Fudan University, Shanghai, China
The mammalian target of rapamycin (mTOR) is a serine–threonine kinase that senses various environmental stimuli. The mTOR signal controls innate and adaptive immune response in…2017 American Transplant Congress
A Novel Equation, GRAIL (GfR Assessment in Liver Disease) Correctly Classifies Patients with Reduced GFR and Predicts Development of ESRD.
1BUMC, Dallas, TX; 2USC, LA, CA; 3NW, Chicago, IL
Estimating glomerular filtration rate(CKD-EPI, MDRD-4, MDRD-6) is poor in liver patients with renal dysfunction(GFR<30ml/min). We developed a model for GFR Assessment In Liver disease(GRAIL) before…2017 American Transplant Congress
IdeS, an IgG Endopeptidase, Effectively Cleaves Anti-CMV IgG, Resulting in Inhibition of Antibody (Ab)-Mediated NK Cell Activation in Kidney Transplant Patients (KTX Pts).
Background: Viral infections represent significant morbidity factors for KTx Pts. Ab-dependent cell-mediated cytotoxicity (ADCC) is a major pathway to eliminate virally infected cells and is…2017 American Transplant Congress
Microcirculation Inflammation in Kidney Allograft Biopsies.
Introduction: The Microcirculation Inflammation (IM) in kidney transplants is a strong predictor of graft loss inde-pedent of C4d and donor specific antibody(DSA)ObjetiveAnalysis of kidney allograft…
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