ATC Abstracts

American Transplant Congress abstracts

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  • 2017 American Transplant Congress

    Vascularized Bone Marrow Mechanisms of Immunomodulation.

    A. Khalifeh, E. Buckingham, M. Uluer, W. Hassanein, W. Twaddell, C. Drachenberg, A. Nam, S. Bartlett, R. Barth.

    University of Maryland School of Medicine, Baltimore, MD

    Introduction:Hand and face transplants containing co-transplanted bone may have improved outcomes. We have previously utilized a NHP model to demonstrate that VCA containing VBM have…
  • 2017 American Transplant Congress

    Molecular Significance of Peritubular Capillaritis in Early Transplant Kidney Biopsies of Donor-Specific Antibody Negative Patients.

    M. Ajaimy, P. O Broin, Y. Bao, E. Akalin.

    Montefiore Medical Center Transplant Center, Albert Einstein College of Medicine, Bronx

    Background: Peritubular capillaritis (PTC) is a part of microvascular inflammation seen in antibody-mediated rejection. However, it can be observed as an isolated lesion in early…
  • 2017 American Transplant Congress

    Preformed HLA Donor-Specific Antibodies Disappearance After Kidney Transplantation: Significance and Comparison with Persistent DSA.

    D. Redondo,1 M. Pérez-Sáez,1 M. Mir,1 J. Gimeno,1 C. García,2 J. Hernández,2 J. Yélamos,3 J. Pascual,1 M. Crespo.1

    1Nephrology Department, Hospital del Mar, Barcelona, Spain; 2Laboratori de Referència de Catalunya, Barcelona, Spain; 3IMIM, Barcelona, Spain

    The presence of donor-specific antibodies (DSA) increase the risk of antibody-mediated rejection (ABMR) and graft failure in kidney transplant recipients (KTR). We aimed to analyze…
  • 2017 American Transplant Congress

    Outcomes of Recurrent Clostridium difficile Infection in Solid Organ Transplant Recipients.

    M. Shiotsuka, Y. Natori, D. Kumar, A. Humar, C. Rotstein, S. Husain.

    Transplant Infectious Diseases, University Health Network, Toronto, ON, Canada

    Introduction:Clostridium difficile infection(CDI) is one of the leading infectious causes among solid organ transplant (SOT) recipients. While the recurrence rate is relatively high, clinical outcomes…
  • 2017 American Transplant Congress

    Identifying Risks and Screening Deceased Organ Donors in the UK for Trypanosoma cruzi .

    I. Ushiro-Lumb,1,2 M. Webster,1 A. Kitchen.1

    1Microbiology Services, NHS Blood and Transplant, London, United Kingdom; 2Virus Reference Department, Public Health England, London, United Kingdom

    Background: In the UK, the Advisory Committee on Microbiological Safety of Blood, Tissues and Organs recommends discretionary T. cruzi antibody screening of donors with identified…
  • 2017 American Transplant Congress

    Dual Role for Caspase-3 in the Regulation of Tubular and Microvascular Damage Post-Renal Ischemia-Reperfusion Injury.

    B. Yang,1,2,3 S. Lan,1,2,3 N. Patey,1,3,4 J. Turgeon,1,3 M. Dieudé,1,3 M.-J. Hébert.1,2,3

    1Research Centre, Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada; 2Canadian National Transplant Research Program, Edmonton, AB, Canada; 3Université de Montréal, Montreal, QC, Canada; 4Department of Pathology, CHU Ste-Justine, Université de Montréal, Montreal, QC, Canada

    Ischemia-reperfusion injury (IRI) in renal transplant recipients is a risk factor of allograft dysfunction and reduced survival. Although tubular epithelial cells (TEC) are classically considered…
  • 2017 American Transplant Congress

    Predictive Value of Serum Biomarkers of Autoimmunity for Recurrence of IgA Nephropathy After Kidney Transplantation.

    N. Maillard,1 H. Suzuki,2 H. Mohey,1 C. Mariat,1 J. Novak,3 B. Julian,4 F. Berthoux.1

    1Nephrology, Dialysis and Renal Transplantation, CHU Saint Etienne, Saint Etienne, France; 2Division of Nephrology, Department of Internal Medicine, Juntendo University, Tokyo, Japan; 3Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL; 4Department of Medicine, University of Alabama at Birmingham, Birmingham, AL

    The recurrence of IgA nephropathy (IgAN) after kidney transplantation is frequent and can cause graft losses. The prediction of the recurrence cannot be performed from…
  • 2017 American Transplant Congress

    Acute Rejection in 6 Antigen HLA Matched Kidney Transplant Recipients: Risk Factors and Outcomes.

    A. Condon, B. Astor, K. Holdener, T. Ellis, A. Djamali.

    University of Wisconsin Health, Madison, WI

    Background: Acute rejection in HLA matched kidney transplant recipients is uncommon, and the mechanisms involved are not well understood.Methods: Data from 6 antigen HLA matched…
  • 2017 American Transplant Congress

    Course of Donor Specific Anti-HLA Antibodies After Induction Therapy with Rituximab in Renal Transplantation.

    M. Baas,1 W. Allebes,2 M. van den Hoogen,3 I. Joosten,2 L. Hilbrands.1

    1Nephrology, Radboud University Medical Center, Nijmengen, Netherlands; 2Blood Transfusion and Transplantation Immunology, Radboud University Medical Center, Nijmegen, Netherlands; 3Internal Medicine, Division of Nephrology and Kidney Transplantation, Erasmus MC, University Medical Center, Rotterdam, Netherlands

    The presence of pre-existing or de novo donor-specific antibodies against HLA (DSA), is associated with a worse graft outcome after renal transplantation. B-cell depletion protocols…
  • 2017 American Transplant Congress

    The Impact of Induction Therapy on Delayed Graft Function Following Kidney Transplantation in Mated Kidneys.

    T. Butler, N. Hayde.

    Department of Transplantation, Albert Einstein-Montefiore, Bronx, NY

    Purpose: Delayed graft function (DGF) is defined as the need for dialysis within one week of transplantation and occurs in 20-50% of deceased-donor kidney transplant…
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