Am J Transplant, Volume 17, Suppl 3 Archives - Page 67 of 181 - ATC Abstracts

2017 American Transplant Congress
Antiretroviral Therapy Modification of HIV+ Patients Listed for Kidney Transplantation.
D. Lee,¹ G. Malat,³ T. Bias,¹ S. Epstein,¹ L. Levin Mizrahi,² M. Harhay,² S. Talluri,² K. Ranganna.²
¹Division of Infectious Diseases and HIV Medicine, Drexel University College of Medicine, Philadelphia; ²Division of Nephrology, Drexel University College of Medicine, Philadelphia; ³Department of Surgery, Drexel University College of Medicine, Philadelphia
Introduction:HIV+ individuals can receive kidney transplant (KT) safely and effectively but face additional challenges from potential drug interactions between antiretroviral therapy (ART) and immunosuppression(IS). Little…
2017 American Transplant Congress
Differences in Kinetics of IFN-y Production Between Endogenous and Allotransplant-Induced Memory T Cells.
B. Gonzalez-Nolasco, J. Marino, W. Orent, G. Benichou.
Center for Transplantation Sciences, Massachusetts General Hospital / Harvard Medical School, Boston, MA
Background:CD8+ memory T cells produce IFN-g in a faster and stronger fashion than their naïve counterparts after allorecognition. Unmanipulated mice possess a proportion of endogenous…
2017 American Transplant Congress
Mechanisms of Fibrosis in the Allograft Kidney: RNA-seq Based Analysis Using Formalin Fixed Biopsies.
G. Zeng,² L. Pan,¹ Z. Lyu,¹ Y. Huang,² P. Randhawa.²
¹Department of Nephrology, Guangxi Medical University, Nanning, Guangxi, China; ²Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA
Development of allograft fibrosis determines long term graft survival but our understanding of this important complication is incomplete. To gain further insight into this problem…
2017 American Transplant Congress
Placental Leukocytes Are Maternally Derived: Implications for Pregnancy-Induced Alloimmunization.
P. Porrett,¹ E. Lewis,² R. Xu,¹ A. Brown,² E. Wherry,³ M. Elovitz.²
¹Surgery, University of Pennyslvania, Philadelphia, PA; ²Obstetrics & Gynecology, University of Pennsylvania, Philadelphia, PA; ³Microbiology, University of Pennsylvania, Philadelphia, PA
Background Alloimmunization of women during pregnancy has significant consequences for both transplant access and outcomes. However, the location and context of maternal immune priming by…
2017 American Transplant Congress
Development of Transplant Glomerulopathy in Recipients with Antibody Mediated Rejection: Activation of Inflammatory Pathway Through Renal Poly (ADP-Ribose) Polymerase (PARP).
B. Ozdemir,¹ F. Ozdemir,² E. Baskin,² M. Haberal.³
¹Pathology, Baskent University, Ankara, Turkey; ²Pediatric Nephrology, Baskent University, Ankara, Turkey; ³Transplant Surgery, Baskent University, Ankara, Turkey
Activation of PARP is a critical factor in the pathogenesis of various inflammatory and fibrotic process. Thus we aimed to show the integral of PARP…
2017 American Transplant Congress
C-C Chemokine Receptor 5 Polymorphisms and Risk of Antibody-Mediated Rejection in Renal Transplantation.
J. Lee,¹ D. Kim,¹ J. Lee,¹ S.-K. Kwon,¹ S. Song,¹ J. Lee,¹ B. Kim,² M. Kim,¹ S. Kim,¹ Y. Kim,¹ K. Huh.¹
¹Transplantation Surgery, Severance Hospital, Yonsei University Health System, Seoul, Republic of Korea; ²Nephrology, Severance Hospital, Yonsei University Health System, Seoul, Republic of Korea
Antibody-mediated rejection (AMR) is the leading cause of graft failure after kidney transplantation. C-C Chemokine receptor 5 (CCR5) plays an important role in immune cell…
2017 American Transplant Congress
Incidence and Clinical Outcomes of Active Tuberculosis in Transplant Recipients from a Low Prevalence Region.
Y. Natori, A. Humar, S. Husain, D. Kumar.
Multi-Organ Transplant Program, UHN, Toronto, Canada
Background: Tuberculosis (TB) is a significant opportunistic infection in solid organ transplant recipients (SOTR). Therapy for TB is complex in this population due to drug…
2017 American Transplant Congress
Efficacy of Trimethoprim-Sulfamethoxazole Prophylaxis for Nocardia in Solid Organ Transplant Recipients (SOTRs): Systematic Review and Meta-Analysis.
A. Alsharidi,¹ A. Gonzalez,² C. Rotstein,³ A. Humar,³ D. Kumar,³ S. Husain.³
¹Medicine, Infectious Diseases, McMaster University, Hamilton, ON, Canada; ²Medicine, Infectious Diseases, University of Florida, Gainesville, FL; ³Multi-Organ Transplant, Transplant Infectious Diseases, University of Toronto, Toronto, ON, Canada
Background:There are increasing reports of breakthrough Nocardia infection in patients taking Trimethoprim-Sulfamethoxazole (TMP-SMX) prophylaxis post SOT. We performed a meta-analysis to evaluate the effectiveness of…
2017 American Transplant Congress
Extended Ex Vivo Kidney Perfusion Using Hemopure as an Oxygen Carrier: A Method to Preserve, Assess and Repair Discarded Organs.
F. Fontan, M. Aburawi, N. Karimian, K. Uygun, F. Delmonico, H. Yeh, J. Markmann.
Transplant Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background: Hypothermic non-oxygenated machine perfusion (HMP) is commonly used in kidney preservation, providing some advantage over static cold storage, as well as flow and resistance…
2017 American Transplant Congress
Longer Anastomotic Time Leads to Delayed Graft Function.
M. Heer,^1,2 P. Trevillian,^1,2,3 A. Hibberd.^1,2,3
¹Newcastle Transplant Unit, John Hunter Hospital, Newcastle, NSW, Australia; ²Newcastle University, Newcastle, NSW, Australia; ³Hunter Transplant Research Foundation, Hunter Medical Research Institute, Newcastle, NSW, Australia
Background: Delayed graft function (DGF) occurs at variable rates in renal transplant recipients. It can be deleterious to renal allograft in long term. Various factors…