Am J Transplant, Volume 17, Suppl 3 Archives - Page 66 of 181 - ATC Abstracts

2017 American Transplant Congress
Is It Safe to Use Older Donor Liver Grafts for Older Recipients?
M. Safwan, K. Collins, K. Takahashi, M. Rizzari, A. Yoshida, M. Abouljoud, S. Nagai.
Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI
Aim: The safety of liver transplantation (LT) using older donor grafts into older recipients remains to be elucidated. The aim of this study was to…
2017 American Transplant Congress
Association of BK and CMV Viremia with Pancreas Allograft Survival Among Adults Receiving Simultaneous Pancreas and Kidney Transplant: The Wisconsin Allograft Recipient Database (WisARD).
F. Aziz, B. Astor, S. Parajuli, N. Garg, B. Muth, D. Mandelbrot, A. Djamali, D. Kaufman, J. Odorico, H. Sollinger, M. Mohamed.
Department of Medicine, University of Wisconsin, Madison, WI
Knowing impact of BKV viremia and CMV infection on pancreas allograft outcome post Simultaneous Pancreas and Kidney transplant (SPK) may improve allograft long-term survival and…
2017 American Transplant Congress
BK Virus in Simultaneous Pancreas Kidney Transplantation.
P. Uva,^1,2 L. Leon,¹ E. Minue,¹ A. Dotta,¹ F. Toniolo,¹ R. Pilotti,¹ E. Chuluyan,² D. Casadei.¹
¹Instituto de Nefrología de Buenos Aires - Nephrology, Buenos Aires, Argentina; ²CEFyBO - CONICET, Buenos Aires, Argentina
BK virus (BKV) may produce nephropathy that could lead to graft failure. The most effective treatment is to decrease immunosuppression (IS). In simultaneous pancreas kidney…
2017 American Transplant Congress
Donor and Recipient Views on Their Relationship in Living Kidney Donation: Thematic Synthesis of Qualitative Studies.
A. Ralph,^1,2 P. Butow,¹ C. Hanson,^1,2 S. Chadban,^1,3 J. Chapman,¹ J. Craig,^1,2 J. Kanellis,⁴ G. Luxton,⁵ A. Tong.^1,2
¹University of Sydney, Sydney, Australia; ²Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, Australia; ³Royal Prince Alfred Hospital, Sydney, Australia; ⁴Monash University, Melbourne, Australia; ⁵University of New South Wales, Sydney, Australia
Background: Many donors and recipients report an improved relationship after transplant, however tension, neglect, guilt and proprietorial concern over the recipient can impede donor and…
2017 American Transplant Congress
Chimerism-Related Allotolerance Is Induced by Exosome Acquisition and Reprogramming of Host Dendritic Cells.
D. Lema,¹ W. Bracamonte-Baran,² E. Jankowska-Gan,¹ F. Claas,³ J. van Rood,³ A. Mulder,³ W. Burlingham.¹
¹Surgery - Transplant Division, University of Wisconsin-Madison, Madison, WI; ²Pathology, Division of Immunology, Johns Hopkins University, Baltimore, MD; ³Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands
Maternal microchimerism (MMc) has been associated with allo-specific graft tolerance in mice and humans. This tolerance is associated with membrane allo-antigen acquisition (mAAQ), which is…
2017 American Transplant Congress
Blocked of Bat3 Expression Promotes Transplant Tolerance by Inducing IL-10 Expression in Dendritic Cells.
G. Gu, H. Hang, Q. Xia.
Department of Hepatic Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
Objective: To explore the effect of Bat3 on DCs during transplant tolerance induction.Methods: Allogeneic heart transplants were performed between WT and Bat3flox/floxCD11c-Cre+ mice, to test…
2017 American Transplant Congress
MERTK Mediates Transplantation Tolerance via Inhibition of TBK1 Phosphorylation and IFN-a Production.
L. Zhang,¹ M. DeBerge,² X. Zhang,³ J. Wang,³ Z. Zhang,³ E. Thorp,² X. Luo.^1,2,3
¹Division of Nephrology and Hypertension, Northwestern University Feinberg School of Medicine, Chicago, IL; ²Department of Microbiology and Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL; ³Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL
Introduction: The TAM (Tyro3, Axl and MERTK) receptor tyrosine kinases (RTKs) mediate homeostatic phagocytosis of apoptotic cells, and transmit regulatory signals that modulate immune response.…
2017 American Transplant Congress
Immunosuppressive Role of Pancreas Derived Mesenchymal Stem Cells.
M. Kanak,¹ F. Kunnathodi,² M. Levy,^1,3 M. Lawrence,² B. Naziruddin.⁴
¹Transplant Surgery, Virginia Commonwealth University, Richmond, VA; ²Baylor Research Institute, Dallas, TX; ³Hume-Lee Transplant Center, VCU Health System, Richmond, VA; ⁴Simmons Transplant Institute, Baylor Scott and White Health, Dallas, TX
BackgroundThe Edmonton protocol revived islet transplantation therapy for Type-1 Diabetic patients. However, Long-term islet function still remains a challenge. Immunosuppression used after islet transplantation contributes…
2017 American Transplant Congress
Identification of Plasma Protein Biomarkers of Acute Renal Allograft Rejection.
M. Rossetti,¹ C. Fitzpatrick,¹ N. Harre,¹ Y. Zheng,¹ N. Mercer,² G. Sunga,¹ D. Gjertson,¹ E. Reed.¹
¹Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA; ²Department of Biostatistics, University of California Los Angeles, Los Angeles, CA
Background & Aim: Upon presentation of clinical symptoms, renal transplant recipients routinely undergo needle core biopsy to diagnose acute graft rejection. This procedure is invasive…
2017 American Transplant Congress
Mechanistic Insights by RNA Profiling on Rejecting Vascularized Composite Allotransplants.
H.-Y. Cheng,¹ S.-C. Liu,² C.-F. Lin,¹ L.-Y. Shih,³ F.-C. Wei.^1,2,3
¹Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; ²College of Medicine, Chang Gung University, Taoyuan, Taiwan; ³Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan
Background: Detailed molecular changes associated with rejection to vascularized composite allotransplants (VCA) are not well understood. Materials and Methods: peripheral blood was drawn from the…