2017 American Transplant Congress
The Intragraft Vascularized Bone Marrow Component and Recipient T Regulatory Cells Facilitate Tolerance Induction After Post Transplant High Dose Cyclophosphamide Treatment in VCA.
Johns Hopkins University School of Medicine, Baltimore, MD
Background: VCA is a viable treatment option for devastating tissue defects. However, the life-long need for immunosuppression curtails the wider use of VCA. Unique VCA-features…2017 American Transplant Congress
In Depth Characterization of Ex Vivo Expanded Polyclonal Regulatory T Cells Used in a Phase I Clinical Trial Following Kidney Transplantation.
Initial clinical trials have investigated the safety of regulatory T cells (Tregs) as a therapy during aberrant immune activation, like graft-versus-host disease (GVHD) following stem…2017 American Transplant Congress
Enhanced Hepatic Engraftment of Stem Cell Derivatives Using Magnetic Targeting into Structurally Normal Liver.
Surgery, University of Texas Medical Branch, Galveston, TX
Attaining consistent robust engraftment in the structurally normal liver is an obstacle for cellular transplantation. Until now, many therapies to increase engraftment after cellular transplantation…2017 American Transplant Congress
Blood Gene Expression Predicts Bronchiolitis Obliterans Syndrome Appearance After Lung Transplantation.
Bronchiolitis obliterans syndrome (BOS) is the main manifestation of chronic lung allograft dysfunction responsible for the poor long-term outcome after lung transplantation. While physiopathological mechanisms…2017 American Transplant Congress
Beneficial Effects of Hydrogen Sulfide (H2S) on Renal Ischemia-Reperfusion Injury (IRI) in CLAWN Miniature Swine.
Center for Advanced Biomedical Science and Swine Research, Kagoshima University, Kagoshima, Japan
Objective: The prevention of IRI is important for both early and long-term graft function, especially when using extended-criteria or donation after cardiac donors. H2S has…2017 American Transplant Congress
Improved Preservation During Normothermic Ex-Vivo Liver Perfusion with Delta Opioid Agonist (D-Ala2, D-Leu5) Enkephalin (DADLE).
Background: The metabolic demand of donor livers during prolonged normothermic ex-vivo perfusion with its associated oxygen stress is a challenge. Delta opioid agonist (D-Ala2, D-Leu5)…2017 American Transplant Congress
Impact of Immunosuppression Adherence on De Novo Donor-Specific Antibody Formation in Renal Transplant Recipients in Canada: A Modeling Analysis.
Acute rejection rates and short-term graft survival have improved substantially as a result of advances in immunosuppression (IS), though longer-term graft survival rates have improved…2017 American Transplant Congress
Steroid Withdrawal Using Everolimus in Maintenance Kidney Transplant Recipients with Post-Transplant Diabetes Mellitus.
Background: Although steroid withdrawal from conventional immunosuppressive therapy has been attempted to ameliorate various complications, especially diabetes mellitus (DM), in kidney transplant recipients, a steroid-sparing…2017 American Transplant Congress
Tacrolimus Dose Requirement Based on the CYP3A5 Genotype in Renal Transplant Patients.
Background The aim of the present study is to determine whether CYP3A5*A and CYP3A5*G genotype is a predictive index of tacrolimus dose requirement, and also…2017 American Transplant Congress
Pre-Transplant Panel Reactive T Cells (PRT) with IL-15 as a Risk-Stratifier of Acute Rejection in Kidney Transplant Patients on Belatacept Therapy.
While kidney transplant recipients treated with bela without calcineurin inhibitors (CNI) have better 5-10y eGFR versus those on CNI, Belatacept (bela) use is associated with…
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