ATC Abstracts

American Transplant Congress abstracts

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  • 2017 American Transplant Congress

    Microarray Analysis of Rejection in Formalin-Fixed Paraffin-Embedded Biopsies: Similarities and Disparities with Conventionally Stabilized Biopsies.

    K. Famulski, J. Revee, P. Halloran.

    Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, AB, Canada

    Despite potential for performing molecular diagnostics on formalin-fixed paraffin embedded (FFPE) biopsies, there has been no systematic comparison of microarray gene expression data obtained from…
  • 2017 American Transplant Congress

    iNKT Cell Activation Plus Veto Cell Transfer Yields Complete Chimerism in a Murine Sub-Lethal Bone Marrow Transplant Model.

    R. Ishii,1 T. Hirai,1 Y. Ishii,2 M. Okumi,1 K. Tanabe.1

    1Department of Urology, Tokyo Women's Medical University, Tokyo, Japan; 2Cluster for Industry Partnerships (CIP), RIKEN, Yokohama, Japan

    Transplant tolerance induction makes it possible to preserve functional grafts for a lifetime without immunosuppressants. We have previously established a novel method for mixed chimera…
  • 2017 American Transplant Congress

    Presence of Complement Activating Donor Specific Antibodies Is Associated with Poor Renal Allograft Survival: Two Centre Retrospective Study.

    A. Babu,1,4,5 O. Shaw,2 L. Howe,2 N. Kessaris,3 A. Dorling,3 N. Mamode,3 R. Vaughan,2 N. Krishnan,5 R. Higgins,5 D. MItchell,1 D. Briggs,4 S. Daga.1,5,6

    1Warwick Medical School, University of Warwick, Coventry, United Kingdom; 2Clinical Transplantation Laboratories, Guy's Hospital, Viapath, London, United Kingdom; 3Nephrology and Transplantation, Guy's Hospital, London, United Kingdom; 4Histocompatibility and Immunogenetics, NHS Blood and Transfusion, Birmingham, United Kingdom; 5Nephrology and Transplantation, University Hospitals Coventry and Warwickshire, Coventry, United Kingdom; 6Nephrology and Transplantation, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom

    Introduction: Complement fixing donor specific antibodies (DSA) as detected by presence of C3d at the time of rejection is associated with poor graft outcome;no studies…
  • 2017 American Transplant Congress

    The Glasgow Prognostic Score and Its Variants Predict Mortality in Living Donor but Not in Deceased Donor Liver Transplantation for Hepatocellular Carcinoma: A Double-Center Validation Study.

    A. Kaltenborn,1 J. Gwiasda,1 N. Heits,2 F. Braun,2 H. Schrem.1

    1Core Facility Quality Management Transplantation, Hannover Medical School, Hannover, Germany; 2Department of General, Visceral-, Thoracic-, Transplantation- and Pediatric Surgery, University Medical Center Schleswig-Holstein, Kiel, Germany

    The notion that inflammation parameters such as CRP and albumin might have an influence on outcome in malignant disease is gaining interest. Serum CRP- and…
  • 2017 American Transplant Congress

    Favorable Long-Term Prognosis of Hepatitis B Surface Antigen Positive Intrahepatic Cholangiocarcinoma for Both Hepatic Resection and Incidental Liver Transplantation via Inhibiting Cancer-Associated Lymphangiogenesis.

    J. Gu, S. Jeong, M. Sha, J. Zhang, Q. Xia.

    Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China

    Background: In recent years, a few publications indicated that hepatitis B virus (HBV) infection is associated with the prognosis of patients with ICC after resection.…
  • 2017 American Transplant Congress

    Accepting a High-KDPI Kidney versus Waiting for Another Offer Can Improve Chances of a Functioning Graft.

    A. Wey,1 N. Salkowski,1 W. Kremers,2 A. Israni,1 B. Kasiske,1 J. Snyder.1

    1Scientific Registry of Transplant Recipients, Minneapolis, MN; 2Mayo Clinic, Rochester, MN

    Less than 50% of waitlisted candidates undergo a first deceased donor transplant within 5 years. Yet approximately 20% of recovered kidneys and >50% of kidneys…
  • 2017 American Transplant Congress

    mRNA Biomarkers in Renal Allograft Protocol Biopsies Detected by the Nanostring Platform Predict Tolerance in Non-Human Primates.

    M. Matsunami,1 T. Oura,1 I. Rosales,2 R.-N. Smith,2 B. Adam,3 M. Mengel,3 A. Cosimi,1 R. Colvin,2 T. Kawai.1

    1Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA; 2Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; 3Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada

    Background. Renal allograft tolerance has been achieved in some but not all MHC mismatched kidneys in non-human primates (NHPs) and humans after induction of transient…
  • 2017 American Transplant Congress

    Assessment of Donor-Reactive T-Cell Immunity by the Novel Urine Cell-Derived Alloantigen Assay Allows Prediction of Acute Rejection in Renal Transplant Patients.

    C. Thieme,1 B. Weist,1 A. Müskes,1 P. Reinke,1 T. Westhoff,2 N. Babel.1,2

    1BCRT (Berlin-Brandenburg Center for Regenerative Therapies), Berlin, Germany; 2Ruhr University Bochum, Bochum, Germany

    Presensitization and donor-specific immunity play a major role in acute and chronic rejection of kidney transplant patients. While assessment of humoral sensitization is well standardised…
  • 2017 American Transplant Congress

    Tacrolimus and Mycophenolic Acid Have a Limited Inhibitory Effect on Monocyte Signaling Pathway Phosphorylation, Function and Differentiation.

    N. Kannegieter,1 D. Hesselink,1 M. Dieterich,1 R. Kraaijeveld,1 A. Rowshani,1 P. Leenen,2 C. Baan.1

    1Internal Medicine, Erasmus MC, Rotterdam, Netherlands; 2Immunology, Erasmus MC, Rotterdam, Netherlands

    Introduction Monocytes and macrophages play key roles in cellular and humoral rejection after solid organ transplantation, but little is known about the effects of the…
  • 2017 American Transplant Congress

    Down-Regulation of Nuclear HMGB1 by Small Interfering RNA Protects Against Liver Ischemia-Reperfusion Injury.

    G. Zhao, C. Fu, L. Wang, L. Zhu, S. Chen, G. Chen.

    Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, HUST, Wuhan, Hubei, China

    Background:High mobility group box 1 (HMGB1) was found to have both a beneficial intracellular role and injurious extracellular role after a sterile inflammatory insult.Hepatocyte-specific HMGB1…
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