2017 American Transplant Congress
A Possible Unintended Consequence of the Kidney Allocation System: The Effect of Duration of Dialysis on Mental Health Outcomes.
Purpose: Long-term dialysis has been shown to adversely affect physical health-related quality of life (HRQOL) but its effect on mental HRQOL and symptoms of depression…2017 American Transplant Congress
Induction of Proliferative Responses in B Cell and Plasma Cell Populations Following Proteasome Inhibitor Desensitization Treatment in Rhesus Macacques and Humans.
1U of Cincinnati, Cincinnati; 2Duke, Durham; 3Cincinnati Childrens, Cincinnati
Proteasome inhibitor (PI)-based desensitization (DS) in humans has demonstrated variable reduction in HLA antibody levels that is often associated with variable rebound following treatment cessation.The…2017 American Transplant Congress
Reduction in Kidney Offer Acceptance at Centers Undergoing Systems Improvement Agreements.
Kidney transplant centers flagged twice by CMS for poor outcomes enter a Systems Improvement Agreement (SIA) if they fail to demonstrate mitigating factors. Motivated to…2017 American Transplant Congress
Share35: Increasing Biliary Complications and Healthcare Resources?
Data has shown that major outcomes of liver transplant post-Share35 have been equivalent to pre-Share35, despite organs accumulating longer CIT and traveling further.The PURPOSE of…2017 American Transplant Congress
Addition of FEV1 Drop to LAS May Improve Access of CF Patients to Transplant: Analysis of the SRTR and US CF Foundation Patient Registries.
1Cleveland Clinic, Cleveland; 2SRTR, Minneapolis; 3CF Foundation, Bethesda
Lung transplant is a widely accepted treatment for cystic fibrosis (CF) end-stage lung disease. The US lung allocation score (LAS) system prioritizes transplant candidates primarily…2017 American Transplant Congress
Higher Tacrolimus Blood Levels Predict Better Graft Survival in Kidney Recipients with De Novo DSA.
Background: De novo anti-HLA donor specific antibodies (dnDSA) are associated with poorer outcomes in kidney transplant recipients. Nonetheless, their monitoring post transplant is not widespread,…2017 American Transplant Congress
Genomic Analysis of Gene Expression in Human Kidney Transplants Identifies Moxd1 as a Key Driver for Renal Fibrosis.
Chronic allograft injury (CAI), characterized histologically by high chronic allograft dysfunction index (CADI) score on biopsy, is known to be a major determinant of graft…2017 American Transplant Congress
Is the Current Heart Allocation System Just and Fair for Blood Type O Recipients? – A Propensity-Matched Analysis of 34353 Patients in the UNOS Registry.
Columbia University Medical Center, New York, NY
Purpose: There is a known disparity between the waiting time on heart transplant (HTx) between blood type O and non-O recipients. This difference is mainly…2017 American Transplant Congress
Dendritic Cell Expression of Rictor (mTORC2), but Not Raptor (mTORC1), Protects Against Renal Ischemia-Reperfusion Injury.
Background: Dendritic cells (DC) are critical initiators of innate immunity in the kidney and orchestrate inflammation subsequent to ischemia-reperfusion injury (IRI). The mechanistic target of…2017 American Transplant Congress
Noninvasive Prognostication of Renal Allograft Failure Following BK Virus Associated Nephropathy – A Validation Study.
Transplant Medicine, Weill Cornell Medicine, NY, NY
Introduction. Identification of kidney transplant (KTx) recipients at risk for graft loss following BKVN diagnosis may allow personalization of immunosuppressive protocols. Previous study demonstrated that…
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