Am J Transplant, Volume 17, Suppl 3 Archives - Page 56 of 181 - ATC Abstracts

2017 American Transplant Congress
Personalized Tacrolimus (TAC) Dosing Using Genetic Variants in Caucasian Kidney Transplant (Tx) Recipients.
D. Margraf,¹ R. Brundage,¹ D. Schladt,² W. Guan,³ B. Wu,³ R. Remmel,⁴ C. Dorr,^2,7 D. Berglund,¹ R. Mannon,⁵ A. Matas,⁶ W. Oetting,¹ A. Israni,^2,7 P. Jacobson,¹ For the DeKAF Genomics Investigators.
¹Dept of Experimental and Clinical Pharmacology, Col of Pharmacy, Univ of Minnesota(UMN), Mpls, MN; ²Chronic Disease Research Group, MPLS Medical Research Foundation, Mpls, MN; ³Div of Biostatistics, School of Public Health, UMN, Mpls, MN; ⁴Dept of Med Chem, Col of Pharmacy, UMN, Mpls, MN; ⁵Dept of Nephrology, Univ of Alabama, Birmingham, AL; ⁶Div of Transplantation, Dept of Surgery, School of Medicine, UMN, Mpls, MN; ⁷Dept of Nephrology, Hennepin County Medical Center, School of Medicine, UMN, Mpls, MN
TAC is an immune suppressant with a narrow therapeutic index and high pharmacokinetic (PK) variability leading to uncertainty in blood concentrations. We previously developed an…
2017 American Transplant Congress
Impact of Polymorphisms of UGT 1 A9 on the Prognosis of Renal Transplant Patients. Association with Digestive Tumors.
N. Calvo, I. Perez-Flores, A. Shabaka, M. Moreno, B. Rodriguez-Cubillo, J. Delgado, M. Calvo, A. Sanchez-Fructuoso.
Nephrologist, Hospital Clinico San Carlos, Madrid, Spain
The aim of this study was to evaluate the distribution of UGT1A9 promoter region T-275A and C-2152T single nucleotide polymorphisms (SNPs) in stable transplant patients…
2017 American Transplant Congress
Influence of Tacrolimus Metabolism Rate on Patients' Survival After Renal Transplantation.
G. Thölking, J. Steinke, K. Schuette-Nuetgen, H. Pavenstädt, B. Suwelack, S. Reuter.
Department of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Münster, Münster, Germany
Introduction: Tacrolimus (Tac) is an integral part of the immunosuppressive regimen after renal transplantation (RTx). A fast Tac metabolism rate defined as the Tac blood…
2017 American Transplant Congress
The IL6/Th17 Pathway May Play Different Roles in Cell-Mediated and Antibody-Mediated Alloimmune Injury in Renal Allografts.
D. Dobi,¹ Q. Tang,² S. Chandran,³ F. Vincenti,³ Z. Laszik.¹
¹Department of Pathology, University of California, San Francisco, San Francisco, CA; ²Department of Surgery, Division of Transplant Surgery, University of California, San Francisco, San Francisco, CA; ³Department of Medicine, Division of Nephrology, University of California, San Francisco, San Francisco, CA
Purpose. IL6 has been shown to contribute to shifting the balance between tolerogenic regulatory T cells and proinflammatory Th17 cells towards the latter. Our study…
2017 American Transplant Congress
Detection of Right Ventricular Dilation and Dysfunction by Transthoracic Echocardiography Predicts Renal Transplant Outcomes.
F. Tinney Jr,¹ S. Lazar,² A. Naik,² M. Samaniego-Picota,² N. Bhave.²
¹Wayne State University School of Medicine, Detroit, MI; ²University of Michigan, Ann Arbor, MI
Introduction: The prevalence of pulmonary hypertension (PHTN) among end stage renal disease (ESRD) patients on hemodialysis is approximately 40-50%. Right heart catheterization is the gold…
2017 American Transplant Congress
A Single Center Retrospective Review of Pediatric Kidney Transplant Outcomes According to Banff Grade and Cellular Rejection Treatment.
J. Chen,¹ R. Liverman,² R. Garro,^2,3 S. Jernigan,^2,3 P. Winterberg.^2,3
¹Morgan Stanley Children's Hospital, New York, NY; ²Children's Healthcare of Atlanta, Atlanta, GA; ³Department of Pediatrics, Emory University, Atlanta, GA
Acute cellular rejection (ACR) remains a major cause of graft dysfunction and loss. There is limited data to provide guidance on optimal treatment strategies stratified…
2017 American Transplant Congress
The Outcome of 0 Mismatch Kidney in Pediatric Population with High Immunologic. The Impact of Induction Therapy. An Analysis of UNOS Database.
V. Whittaker, M. Laftavi, Z. Acun, R. Gruessner, A. Gruessner.
Surgery, State University New York, Syracuse, NY
Background: 0 mismatch kidneys have superior outcomes in primary transplant recipient. We performed Analysis UNOS database to determine the outcome of high PRA transplant pediatric…
2017 American Transplant Congress
An Argument for Expanding the Simultaneous Liver and Kidney Transplant Criteria: Validity of the New UNOS Allocation Policy.
S. Nagai,¹ M. Safwan,¹ K. Collins,¹ M. Rizzari,¹ D. Moonka,² K. Brown,² A. Patel,³ A. Yoshida,¹ M. Abouljuod.¹
¹Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI; ²Gastroenterology, Henry Ford Hospital, Detroit, MI; ³Nephrology, Henry Ford Hospital, Detroit, MI
Aim: According to the latest simultaneous liver-kidney transplant (SLK) allocation policy by UNOS, allocation of kidney is dependent on duration of low glomerular filtration rate…
2017 American Transplant Congress
Impact of Donor Genotype on Recipient Tacrolimus Pharmacokinetics: The Liver Matters.
S. Tremblay,¹ T. Fukuda,² T. Mizuno,² E. Woodle,¹ B. Abu Jawdeh,¹ A. Govil,¹ U. Christians,³ J. Klawitter,³ A. Vinks,² R. Alloway.¹
¹U of Cinicnnati, Cincinnati; ²Cincinnati Children's, Cincinnati; ³iC42 Clinical Research, Colorado
Tacrolimus (Tac) is a cornerstone immunosuppressant metabolized in the gut and liver, resulting in high intra/inter patient pharmacokinetic (PK) variability. Recipient genotype (RG) impacts tac…
2017 American Transplant Congress
Treating Refractory Liver Allograft Rejection with Photopheresis.
I. Lopez Plaza,¹ A. Eisenbrey,¹ M. Raoufi,¹ A. Yoshida,² D. Moonka.²
¹Department of Pathology and Laboratory Medicine, Henry Ford Health System, Detroit, MI; ²Transplant Institute, Henry Ford Health System, Detroit, MI
DSAs with persistent high titer alloantibodies are associated with refractory antibody mediated rejection (AMR) and liver injury.METHODS: We present 4 liver transplant (LT) patients refractory…