2017 American Transplant Congress
Waitlist Desensitization and the Rate of Deceased Donor Kidney Transplantation After Implementation of the Kidney Allocation System.
Comprehensive Transplant Center, Cedars Sinai Medical Center, Los Angeles, CA
Background:At Cedars Sinai Medical Center (CSMC), candidates with calculated panel reactive antibodies (cPRA) ≥30% (based on unacceptable antigens with MFI≥15,000) are desensitized while awaiting transplant.…2017 American Transplant Congress
Tacrolimus Trough Concentration Variability and Disparities in African American Kidney Transplantation.
Low tacrolimus (FK) trough concentrations have been associated with higher risk of acute rejection, particularly within African-American (AA) kidney transplant recipients; less is known about…2017 American Transplant Congress
Circulating Exosomes Isolated from Human Lung Transplant Recipients with Rejection Are Immunogenic and Induce Antibodies to Lung Associated Self-Antigens, Kα1 Tubulin and Collagen-V.
Norton Thoracic Institute, St. Joseph's Hospital and Med Center, Phoenix
Background: Exosomes isolated from acute and chronic rejections in lung transplant recipients (LTxR) demonstrated surface expression of mismatched donor human leukocyte antigen and lung associated…2017 American Transplant Congress
Post-Transplant Reduction in Pre-Existing Donor-Specific Antibody Levels After Belatacept- vs Cyclosporine-Based Immunosuppression.
1Emory University, Atlanta, GA; 2Bristol-Myers Squibb, Lawrenceville, NJ
Purpose: We explored the effect of belatacept (bela)- and cyclosporine (CsA)-based immunosuppression (IS) on pre-existing donor-specific antibody (DSA) levels by mean fluorescence intensity (MFI) in…2017 American Transplant Congress
Rapamycin Directly Alters Human Endothelial Cell Alloimmunogenicity.
The mTOR inhibitor rapamycin (Rapa) is known to suppress T cell function. However, many of its in vivo effects, particularly its synergistic effects with costimulation…2017 American Transplant Congress
Improving Communication of SRTR Transplant Program Outcomes Evaluations Using a 5-Tier System.
Scientific Registry of Transplant Recipients, Minneapolis
SRTR developed a 5-tier outcome assessment to improve the accessibility and understanding of the program outcomes evaluations SRTR performs as mandated by the Final Rule…2017 American Transplant Congress
Extra-Renal Cardiac Injury Is Associated with Upregulation of NOD2 and Nlrp3 in the Heart After Renal IRI.
Medicine, Division of Nephrology and Hypertension, University of California San Diego, La Jolla, CA
Background: Recent studies show renal ischemia reperfusion injury (IRI) is associated with systemic release of danger associated molecular patterns (DAMPs). DMAPs induce significant extra-renal organ…2017 American Transplant Congress
BK Polyomavirus-Specific 9mer T-Cell Responses Predict Control of Viremia in Kidney Transplant Recipients: First Report from the Swiss Transplant Cohort Study.
BK polyomavirus (BKPyV) causes premature kidney transplant (KT) failure in 1-15% of patients. Since antivirals are lacking, most programs screen KT patients for BKPyV viremia…2017 American Transplant Congress
Effects of Liver Transplantation on Cardiac Function in Patients Transplanted for NASH Cirrhosis.
Internal Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL
Nonalcoholic Steatohepatitis (NASH) is independently associated with increased cardiovascular events after liver transplantation (LT). NASH is also associated with subclinical myocardial dysfunction in the general…2017 American Transplant Congress
Expression of T-Cell Mediated Rejection (TCMR) Associated Genes in Native and Renal Allograft Renal Biopsies with Inflamed Scars (i-IFTA).
The presence of i-IFTA in allograft kidney biopsies is a bad prognostic parameter. However, despite the presence of T-cell infiltrates in these lesions there is…
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