2017 American Transplant Congress
Clinical and Molecular Significance of Microvascular Inflammation Negative Transplant Glomerulopathy.
Transplant glomerulopathy (TGP) with donor specific antibodies (DSA) and microvascular inflammation (MVI) is due to chronic antibody mediated rejection (CAMR). We reported previously that intragraft…2017 American Transplant Congress
Tocilizmab (Anti-IL-6R) Treatment (TCZ-Rx) Reduced Total IgG Levels Including Anti-HLA IgG: Analysis of IgG Subclasses (IgG1-IgG4) and Anti-HLA IgG Subclasses Show Similar Reductions in All Subclasses from Patients with DSA+ Chronic Antibody-Mediated Rejection (CABMR).
Background: DSA+ CABMR constitutes the major cause for renal allograft loss in the U.S. Currently there are no approved therapies. We have reported TCZ use…2017 American Transplant Congress
Vancomycin Prophylaxis for Prevention of Clostridium difficile Recurrence in Renal Transplant Patients.
Purpose: Clostridium difficile infection (CDI) is higher in solid organ transplant recipients. IDSA/SHEA guidelines do not recommend prophylactic (PROPH) vancomycin (VANC) or metronidazole in CDI…2017 American Transplant Congress
Incidence of Fungal and Viral Infections Following Rituximab Use in Kidney Transplant Recipients.
Northwestern Memorial Hospital, Chicago, IL
Rituximab is used off-label in solid organ transplant for desensitization and treatment of antibody-mediated rejection (AMR). It targets CD20 and results in B cell depletion.…2017 American Transplant Congress
Histone Deacetylase Inhibition Mitigates Liver Ischemia/Reperfusion Injury in Mice.
Introduction: Ischemia/reperfusion injury (IRI) causes significant morbidity in liver transplantation and other surgical scenarios. A better understanding of the molecular mechanisms of IRI is required…2017 American Transplant Congress
Short Term Renal Allograft Outcomes Following Treatment of Early Subclinical Borderline Changes on Surveillance Biopsies.
University of Michigan, Ann Arbor, MI
There is no consensus on treating subclinical borderline changes on surveillance biopsy in kidney transplant (KT) recipients. We examined whether treatment with pulsed corticosteroids led…2017 American Transplant Congress
Streamlining Discharge Pathways in Kidney Transplant Recipients with Delayed Graft Function.
Background180 end-stage renal disease (ESRD) patients undergo kidney transplantation at the Toronto General Hospital Multi-Organ Transplant Unit yearly. 30% develop delayed graft function (DGF), defined…2017 American Transplant Congress
Classification of Fibromuscular Dysplasia in Kidney Donors Based on Severity and Extent of Lesion.
Introduction: Selection of living kidney donors (LKD) with renal artery (RA) fibromuscular dysplasia (FMD) is controversial, as traditional diagnostic classifications lack estimates on FMD severity.…2017 American Transplant Congress
Induction Treatment with Rabbit Antithymocyte Globulin versus Basiliximab in Renal Transplant Recipients with Planned Early Steroid Withdrawal.
Transplant Surgery, Brigham and Women's Hospital, Boston
Introduction: In a previous study by our group, rabbit antithymocyte globulin (r-ATG) induction was associated with lower rates of rejection when compared to basiliximab in…2017 American Transplant Congress
Readmissions After Liver Transplantation–They May Be Predictable, but Are They Inevitable?
Dept of Tx Surgery, Tx ICCE, Dept of Pharmacy, MUSC, Charleston, SC
Purpose: Published studies suggest that approximately 40% of OLTx recipients are readmitted within 30 days. The aim of this study is to analyze the risk…
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