Am J Transplant, Volume 17, Suppl 3 Archives - Page 50 of 181 - ATC Abstracts

2017 American Transplant Congress
Induced Pluripotent Stem Cell (iPS) Derived Schwann Cells to Enhance Functional Recovery Following Nerve Injury and Limb Allotransplantation.
B. Kern,¹ K. Sarhane,² Z. Ibrahim,² B. Mukherjee-Clavin,³ J. Budihardjo,² C. Cashman,³ K. Krick,⁴ S. Schneeberger,¹ W. Lee,² H.-Q. Mao,⁴ G. Lee,³ G. Brandacher.²
¹Operative Medicine, Innsbruck Medical University, Innsbruck, Austria; ²Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; ³Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD; ⁴Materials Science and Engineering, Johns Hopkins University School of Medicine, Baltimore, MD
Background Stem cell therapies have provided new aspects for functional recovery. A novel cell-based approach utilizing human induced Pluripotent Stem Cell-derived Schwann Cells (iPSC-SCs) supported…
2017 American Transplant Congress
Noninvasive Renal Transplant Graft Monitoring in Single Institution Using Cell-Free DNA in Recipient Plasma via Insertion-Deletion Allele Polymorphism.
Y. Goh,¹ S. Ho,² L. Raman,¹ V. Anantharaman,³ T. Goh,³ S. Koay,² H. Tiong.¹
¹Urology, National University Hospital, Singapore, Singapore; ²Laboratory Medicine, National University Hospital, Singapore, Singapore; ³Nephrology, National University Hospital, Singapore, Singapore
IntroductionThere is an unmet clinical need in renal transplantation towards early detection of donor organ damage. Serum creatinine(SCr) and biopsies are not ideal.Cell-free donor DNA(cfdDNA)…
2017 American Transplant Congress
Next-Generation Sequencing-Based Exosome MicroRNA Profiling for Specific Identification of Islet Damage.
P. Saravanan,¹ J. Gu,¹ X. Wang,¹ P. Nguyen,¹ G. Yoshimatsu,¹ M. Lawrence,¹ B. Naziruddin.²
¹Baylor Scott and White Research Institute, Dallas, TX; ²Baylor Simmons Transplant Institute, Dallas, TX
Introduction: A significant mass of intraportally transplanted islets undergo damage due to various stress conditions including hypoxia and inflammation. Development of innovative ultrasensitive tests to…
2017 American Transplant Congress
ERK and HIF1 Play a Major Role in Hypothermic Protection Against Renal Ischemia-Reperfusion Injury.
K. Lee,¹ J. Jeong,² D. Choi,¹ K. Na,¹ H. Bae,¹ Y. Ham.¹
¹Chungnam National University, Nephrology, Daejeon, Korea; ²Chungnam National University, Department of Medical Science, Daejeon, Korea
Purpose: Hypothermia attenuates the renal injury induced by ischemia-reperfusion. However, the detailed molecular pathway remains unknown. ERK and HIF1 are known to protect against ischemia-reperfusion…
2017 American Transplant Congress
High Risk Renal Transplant Recipients on Steroid Free Immunosupression Regimen. Indiana University Experience.
O. Adebiyi, S. Hussain, D. Mishler, W. Goggins, M. Yaqub, T. Taber, A. Sharfuddin.
Renal Transplant, Indiana University School of Medicine, Indianapolis, IN
Background : Immunologic risk often influence the choice immunosuppressive regimen used in renal transplant recipient. Patient with positive flow cytometry crossmatch (FCXM) or presence of…
2017 American Transplant Congress
Population Pharmacokinetic Profiling of Tacrolimus in Renal Transplant Recipients (RTRs) Taking Diltiazem.
P. Trevillian,^1,2,3 M. Heer,^1,2 S. Ainsworth,¹ A. Hibberd.^1,2,3
¹Newcastle Transplant Unit, John Hunter Hospital, Newcastle, NSW, Australia; ²University of Newcastle, Newcastle, NSW, Australia; ³Hunter Transplant Research Foundation, Hunter Medical Research Institute, Newcastle, NSW, Australia
Background: Over the past 6 years we have prospectively used pharmacokinetic (PK) profiling of Tacrolimus (TAC) in “stable” RTR's to individualise future dosing. This study…
2017 American Transplant Congress
Conversion from Calcineurin Inhibitor to Sirolimus in Kidney Transplantation Recipients with Malignancy.
J. Yoon, S. Kang, S. Kim, C. Baeck, H. Kim, S.-K. Park.
Nephrology, Asan Medical Center, Seoul, Republic of Korea
Background: Kidney transplant recipients are at an increased risk of malignancy for various reasons, such as the chronic use of calcineurin inhibitor (CNI). Sirolimus (SRL),…
2017 American Transplant Congress
Pro Inflammatory Transitional B (TrB) Cells Characterize Renal Allograft Recipients with DSA and T Cell Mediated Rejection (TCMR).
A. Sharma, A. Cherukuri, D. Rothstein.
UPMC, Pittsburgh
De novo DSA detected post-renal transplantation is associated with adverse outcomes. We have shown that de novo DSA is strongly associated with TCMR. In this…
2017 American Transplant Congress
Post-Transplant Graft Function Is Associated with Major Cardiovascular Events in Kidney Transplant Recipients: A Multicenter Cohort Study.
J. Park,¹ Y. Kim,² S. Yang,³ S. Park,² S.-K. Park,⁴ D. Han,⁵ Y. Kim,² Y. Kim,⁵ J. Lee.⁶
¹Department of Internal Medicine, Dongguk University Ilsan Hospital, Gyeonggi-do, Korea; ²Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; ³Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea; ⁴Department of Internal Medicine, Asan Medical Center and University of Ulsan College of Medicine, Seoul, Korea; ⁵Department of Surgery, Asan Medical Center and University of Ulsan College of Medicine, Seoul, Korea; ⁶Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea
Background: Reduced kidney function is an independent risk factor for cardiovascular disease in the general population. However, the association between post-transplantation graft function and subsequent…
2017 American Transplant Congress
Early Introduction of Oral Paricalcitol in Renal Transplant Recipients. An Open-Label Randomized Study.
H. Pihlstrøm,¹ F. Gatti,² C. Hammarstrom,² I. Eide,¹ M. Kasprzycka,² J. Wang,² G. Haraldsen,² M. Svensson,³ K. Midtvedt,¹ A. Hartmann,¹ G. Mjøen,¹ D. Dahle,¹ H. Holdaas.¹
¹Department of Surgery, Inflammation Medicine and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway; ²Department of Pathology, Oslo University Hospital Rikshospitalet, Oslo, Norway; ³Department of Nephrology, Akershus University Hospital, Oslo, Norway
In stable renal transplant recipients with hyperparathyroidism, the vitamin D agonist paricalcitol reduces level of proteinuria. Animal studies indicate possible anti-fibrotic and anti-inflammatory effects. The…