2017 American Transplant Congress
A Molecular Signature Characterized by Dominance of Negative Regulation over Cytotoxic Effectors in Tolerant Kidney Allograft Recipients.
Introduction. Development of tolerance biomarkers is important for interrogating the in-vivo immune status of patients entered in clinical trials of tolerance.Methods. To determine the feasibility…2017 American Transplant Congress
Treating Ischemically Damaged Porcine Kidneys with Mesenchymal Stromal Cells During Normothermic Machine Perfusion.
Normothermic machine perfusion (NMP) could provide superior organ preservation and offers the unique opportunity for interventions to an isolated kidney prior to transplantation. There is…2017 American Transplant Congress
Hepatitis B Virus Infection Is Associated with Recurrent Nephropathy After Kidney Transplantation.
Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Background Hepatitis B virus(HBV) infection can cause HBV associated nephropathy, and is one of the major reasons for secondary nephropathy. We carried out a retrospective…2017 American Transplant Congress
Post-Donation Experiences of Non-Directed (Altruistic) Living Kidney Donors in the United States.
A. Non-directed donors (NDDs) can potentially help alleviate the overburdened kidney transplant waiting list while also improve the quality of life for patients with end-stage…2017 American Transplant Congress
Circulating Donor-Specific Anti-HLA Antibodies Accelerate the Progression of Interstitial Fibrosis in Kidney Allografts.
Paris Translational Research Center for Organ Transplantation, Paris, France
Interstitial fibrosis represents a major cause of kidney allograft failure. Addressing the causes of accelerated ageing of kidney allografts represents an important challenge to improve…2017 American Transplant Congress
36 Hours of Ex-Vivo Warm Cellular Perfusion of Swine Liver Using the Organ Care System (OCS™) Liver with Excellent Functional, Metabolic and Histological Outcomes.
Cold storage preservation results in ischemia/reperfusion injury to the donor liver, it lacks any resuscitative or assessment capabilities. The OCS™ Liver maintains livers in a…2017 American Transplant Congress
Experience with Obinutuzumab (Type II Anti-CD20) in Kidney Transplant Patients with Donor Specific Antibody (DSA+) Antibody Mediated Rejection.
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
Introduciton:Rituximab is a type I chimeric IgG1 anti-CD20 antibody that has revolutionized the management and treatment of B-cell malignancies, and numerous autoimmune diseases. In addition,…2017 American Transplant Congress
TIM-4 Identifies Pro-Inflammatory B Effector Cells That Are Potent Drivers of Alloimmunity and Allograft Rejection Through Expression of Both IFN-γ and IL-17.
Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh
B cells can either augment or inhibit immune responses due to the presence both regulatory (Bregs) and effector (Beff) B cells expressing anti- or pro-…2017 American Transplant Congress
CD47 Blockade Reduces Ischemia/Reperfusion Injury in Donation After Cardiac Death Rat Kidney Transplantation.
Purpose: We evaluated the potential effects of antibody-mediated CD47 blockade to modulate vascular endothelial nitric oxide activity and reduce ischemia reperfusion injury in a rat…2017 American Transplant Congress
Importance of Acquisition of Carbapenemase (KPC)-Producing Enterobacteriaceae in Solid Organ Transplant Recipients: A Single-Center Experience.
Background: Among multi-drug resistant bacteria, carbapenem-resistant Enterobacteriaceae (CRE) is recently spreading in several countries. Carbapenemase-producing (CP) Enterobacteriaceae (CPE) has great clinical importance because it could…
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