2017 American Transplant Congress
The Impact of the New Kidney Allocation System on Living Donor Kidney Transplantation(LDTX) Among Patients in the Lowest Quintile of Expected Post-Transplant Survival (EPTS).
Division of Nephrology, University of British Columbia, Vancouver, Canada
Background: Changes in deceased donor allocation policy may impact LDTX.The prioritization of patients in the top 20% of EPTS to receive deceased donor kidneys in…2017 American Transplant Congress
Barriers and Experiences When Patients Decide on a Kidney Transplant Center.
Choosing a transplant center is one decision in a long pre-transplant process facing many patients. Qualitative studies have previously been used to better understand the…2017 American Transplant Congress
B Cell-Derived Cytokines Rather Than T/B Cognate Interactions Mediate CD8 T Cell Reconstitution Following Lymphoablation.
Immunology, Cleveland Clinic, Cleveland, OH
Antibody-mediated lymphoablation is a commonly used induction therapy in sensitized transplant recipients. Using murine anti-thymocyte globulin (mATG) in a model of BALB/c (H-2d) to B6…2017 American Transplant Congress
Efficacy and Safety of ASP0113 versus Placebo in CMV-Seronegative Kidney Transplant Patients Receiving an Organ from a CMV-Seropositive Donor.
Introduction: ASP0113 is a first-in-class DNA-based vaccine in development for the prevention of human cytomegalovirus (CMV) infection in at-risk hematopoietic cell transplant and solid organ…2017 American Transplant Congress
CD16a-Activated NK Cells in ABMR Are Highly Similar to CD3-Activated Effector T Cells in TCMR.
University of Alberta, Edmonton, Canada
BACKGROUND: NK cell CD16a and T cell CD3 activate shared pathways. Since NK cell CD16a activation occurs in antibody-mediated rejection (ABMR) and T cell CD3…2017 American Transplant Congress
Inflammatory Cytokines Are Associated with Angiotensin II Type 1 Receptor Antibodies and Vascular Inflammation in Pediatric Renal Transplantation.
1University of California, Los Angeles, CA; 2Duke University, Durham, NC
Background: We recently found that angiotensin II type 1 receptor antibody (AT1R-Ab) was associated with decreased renal function in pediatric renal transplant recipients independent of…2017 American Transplant Congress
Predicting Immunologic Risk for Acute Rejection in Pediatric Liver Transplantation.
Yale University, New Haven, CT
Background: Studies in heart, lung, kidney, & liver transplantation (LT) indicate an increased negative impact of antibodies (Ab) to HLA on allograft outcome.Aim: To describe…2017 American Transplant Congress
Educational Strategies for Increased Wait-Listing Rates: Opportunities for Dialysis Center Intervention.
1UCLA, Los Angeles, CA; 2SLU, St. Louis, MO
Dialysis centers vary in how well they educate patients about kidney transplant (KT). This study categorized common groups of educational strategies used by dialysis staff;…2017 American Transplant Congress
Characterization of Human Plasma Cell Proteasome Adaptations to Proteasome Inhibitor Therapy: A Precision Medicine Approach to Overcome Drug Resistance in Desensitization.
1U of Cincinnati, Cincinnati, OH; 2Cincinnati Children's, Cincinnati, OH
Purpose: Bone marrow niche-resident plasma cells (BMNRPCs) exhibit variable sensitivity to proteasome inhibitor (PI) therapy. Here, we characterized alterations in the gene and protein expression…2017 American Transplant Congress
Venous Thromboembolism and the Risk of Death and Graft Loss in Kidney Transplant Recipients.
Background: The incidence of venous thromboembolism (VTE) in kidney transplant recipients varies widely in the literature. The implications of VTE for morbidity and mortality in…
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