2017 American Transplant Congress
Applicability and Safety of a Regulatory T Cell Therapy in Adult Liver Transplantation: The “ThRIL” Phase I First-in-Human Trial.
MRC Centre for Transplantation, King's College London, London, United Kingdom
Aim“ThRIL” is a multiple site, open-label, uncontrolled, phase I clinical trial assessing the safety and applicability of a CD4+CD25+FOXP3+ regulatory T cell (Treg) immunotherapy in…2017 American Transplant Congress
Kidney Injury Molecule-1 Mitigates Tissue Damage from Transplant Renal Ischemia Reperfusion Injury.
Ischemia reperfusion injury (IRI) at the time of organ harvesting is unavoidable, may cause delayed renal graft function, and is associated with premature graft loss.…2017 American Transplant Congress
BK Polyomavirus-Specific 9mer T-Cell Responses Predict Control of Viremia in Kidney Transplant Recipients: First Report from the Swiss Transplant Cohort Study.
BK polyomavirus (BKPyV) causes premature kidney transplant (KT) failure in 1-15% of patients. Since antivirals are lacking, most programs screen KT patients for BKPyV viremia…2017 American Transplant Congress
Effects of Liver Transplantation on Cardiac Function in Patients Transplanted for NASH Cirrhosis.
Internal Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL
Nonalcoholic Steatohepatitis (NASH) is independently associated with increased cardiovascular events after liver transplantation (LT). NASH is also associated with subclinical myocardial dysfunction in the general…2017 American Transplant Congress
Expression of T-Cell Mediated Rejection (TCMR) Associated Genes in Native and Renal Allograft Renal Biopsies with Inflamed Scars (i-IFTA).
The presence of i-IFTA in allograft kidney biopsies is a bad prognostic parameter. However, despite the presence of T-cell infiltrates in these lesions there is…2017 American Transplant Congress
Ex-Situ Extended Limb Preservation: A Protocol for Porcine Limb Perfusion.
1Plastic Surgery, Cleveland Clinic, Cleveland, OH; 2General Surgery, Cleveland Clinic, Cleveland, OH
Background: Ischemia and reperfusion injury remains a significant limiting factor for the success of vascularized composite allotransplantation. Compared to the cold storage of the procured…2017 American Transplant Congress
Meta-Analysis of Clinical Significance of Complement Activating Anti-HLA DSA in Kidney Transplantation.
Donor-specific anti-HLA antibodies (DSA) are currently recognized as the major limitation to access transplantation and the first cause of late transplant failures. The effect of…2017 American Transplant Congress
Podocyte-Specific Knockdown of SHROOM3 Causes Albuminuria and Foot-Process Effacement by Interaction with FYN.
Nephrology, Medicine, Icahn School of Medicine, New York, NY
In the translational GoCAR study, we identified that a CKD-associated SHROOM3-SNP, and tubular SHROOM3 expression correlated with the development of renal fibrosis post-transplant. The SNP…2017 American Transplant Congress
Single Kidney Transplantation from DCD Maastricht Category 3 Donors ≥ 60 Years: Is It Safe?
Aim. Compared to DBD, DCD kidneys show higher rates of primary non function (PNF), DGF, rejection, and premature transplant (Tx) loss. Some authors have advised…2017 American Transplant Congress
Performance-Based vs. Self-Reported Functional Assessment on Outcomes After Kidney Transplant.
Renal and Pancreas Transplant Department, Saint Barnabas Medical Center, Livingston, NJ
Reduced functional capacity (FC) is associated with poor outcomes and early hospital readmission after kidney transplant (KT). The aim of the study was to determine…
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