Am J Transplant, Volume 17, Suppl 3 Archives - Page 43 of 181 - ATC Abstracts

2017 American Transplant Congress
Long-Term Outcomes After Liver Transplantation (tx) with Everolimus (EVR) and Mycophenolic Acid (MPA) in a Calcineurin Inhibitor-Free Regimen: The CERTITUDE Trial.
F. Saliba,¹ C. Duvoux,² S. Dharancy,³ J. Dumortier,⁴ Y. Calmus,⁵ F. Di Giambattista,⁶ F. Conti.⁵
¹AP-HP Hôpital Paul Brousse, Villejuif, France; ²AP-HP Hôpital Henri Mondor, Créteil, France; ³CHRU de Lille, Lille, France; ⁴Hôpital Edouard Herriot, Lyon, France; ⁵AP-HP Hôpital Pitié Salpêtrière, Paris, France; ⁶Novartis Pharma SAS, Rueil-Malmaison, France
Background. Long-term outcomes under EVR with MPA and no calcineurin inhibitor are undocumented after liver tx.Methods. CERTITUDE is a prospective, multicenter, observational study of liver…
2017 American Transplant Congress
A Novel Belatacept Regimen to Optimize Efficacy and Safety.
D. Wojciechowski,¹ S. Chandran,² M. Sarwal,² J. Yang,² F. Vincenti.²
¹MGH, Boston; ²UCSF, San Francisco
Despite superior long term graft survival when compared to cyclosporine, the use of the FDA approved belatacept regimen in clinical practice has been constrained by…
2017 American Transplant Congress
Rituximab Desensitization (DES) and Alemtuzumab Induction Significantly Reduced EBV Viremia and Post-Transplant Lymphoproliferative Disorder (PTLD) in HLA-Sensitized (HS) Kidney Transplant Patients.
B.-H. Shin,¹ S. Ge,¹ J. Mirocha,² D. Thomas,¹ E. Rodriguez,¹ C. Chao,¹ O. Galera,¹ A. Vo,¹ J. Choi,¹ A. Peng,¹ J. Kahwaji,¹ S. Jordan,¹ M. Toyoda.¹
¹Transplant Immunology Laboratory and Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; ²Biostatistics Core, Cedars-Sinai Medical Center/UCLA School of Medicine, Los Angeles, CA
Background: PTLD is a serious complication in KTx pts and is usually associated with EBV infection. Recent studies showed that rituximab treatment prior to Tx…
2017 American Transplant Congress
Inflammasome, Unfolded Protein Response, and T Cell Immunity in DAIH.
A. Arterbery,¹ M. Martinez,³ S. Lobritto,³ Y. Avitzur,² U. Ekong.¹
¹Ped Gastro. and Hep., Yale University, New Haven, CT; ²Gastro., Hep., and Nutr., Hospital for Sick Children, Toronto, ON, Canada; ³Ped. Gastro., Hep., and Nutr., Columbia University, New York, NY
Background: Regulatory T cells (Tregs) of patients with de novo autoimmune hepatitis (DAIH) secrete IL-17A & IFN-g; display TH1 & TH17 pehnotypes & are functionally…
2017 American Transplant Congress
Circulating Donor-Specific Memory B Cells (mBc) Discriminates Kidney Transplant Patients with Histological Lesions of ABMR in Absence of Circulating DSA.
S. Luque,² M. Lúcia,⁴ M. Jarque,² E. Crespo,² E. Melilli,¹ J. Martorell,³ J. Cruzado,^1,2 J. Torras,^1,2 J. Grinyó,^1,2 O. Bestard.^1,2
¹Kidney Transplant Unit, Nephrology Department, Bellvitge University Hospital, Barcelona, Catalunya, Spain; ²Experimental Nephrology Laboratory, IDIBELL, Barcelona, Catalunya, Spain; ³Immunogenetics Laboratory, Hospital Clínic, Barcelona, Catalunya, Spain; ⁴Transplant Immunology, School of Medicine, Stanford
Chronic (c)ABMR is a main cause of immune-mediated kidney allograft loss. For its diagnosis, specific histological lesions together with presence of circulating donor-specific alloantibodies (DSA)…
2017 American Transplant Congress
The Beneficial Effect of Janus Kinase 3 Inhibitor on Transplanted Islet via Protection from Oxidative Stress-Induced β Cell Death.
S.-J. Kang,^1,2,3,4 H. Chung,^1,2,3,4 S. Lee,^1,2,3,4 J.-S. Shin,^1,3,5 H.-J. Kim,^1,2,3,4 J.-M. Kim,^1,3,5 B.-H. Min,^1,3,5 S. Choi,^1,2,3,4 C.-G. Park.^1,2,3,4,5
¹Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Korea; ²Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea; ³Xenotransplantation Research Center, Seoul National University College of Medicine, Seoul, Korea; ⁴Department of Biomedical Sciences, Seoul National University, Seoul, Korea; ⁵Institute of Endemic Diseases, Seoul National University College of Medicine, Seoul, Korea
Janus kinase 3 (JAK3) is one of the molecules that make up the JAK-STAT signaling pathway that regulates numerous 40 cytokines. Thus, this cascade can…
2017 American Transplant Congress
The Impact of Belatacept on Anti-HLA Antibodies of Highly Sensitized Kidney Transplant Recipients.
R. Parsons, H. Decker, T. Pearson, C. Larsen, R. Bray, H. Gebel.
Emory Transplant Center, Atlanta, GA
Background: Anti-HLA antibodies often prevent successful organ transplantation. Interestingly, belatacept limits de novo antibody production within the germinal center, but its impact on long-lived plasma…
2017 American Transplant Congress
Women in the United States Receive More Resections and Ablations for Hepatocellular Carcinoma Than Men.
L. Sobotka,¹ A. Hinton,² L. Conteh.¹
¹The Ohio State Wexner Medical Center, Columbus; ²The Ohio State University, Columbus
Background: Previous studies have shown conflicting data regarding gender disparities in the treatment of hepatocellular carcinoma. Several studies have suggested that men are more likely…
2017 American Transplant Congress
Serum AFP Greater Than 200 ng/ml as a Predictor for Low Survival in Patients with Hepatocelullar Carcinoma Recurrence in a Brazilian Multicentric Study.
I. Boin,¹ M. Possatto,¹ E. Ataide,¹ R. Silva,² R. Silva,² H. Felicio,² L. Amado,³ A. Lima,³ T. Seva-Pereira.¹
¹Unit of Liver Transplantation, State University of Campinas, Campinas, SP, Brazil; ²Digestive Surgery - Liver Transplantation, Faculty of Medicine- São Jose do Rio Preto, Rio Preto, SP, Brazil; ³Digestive Surgery - Liver Transplantation, Faculty of Medicine, Federal University of Minas Gerais, Minas Gerais, Brazil
Introduction: Liver transplantation (LT) is the only potential curative treatment for hepatocellular carcinoma (HCC) with recurrence (HCC-R) diagnosed in 16%. Aim: The objective of this…
2017 American Transplant Congress
Facing Unintended Challenges of Increased Risk Donor Kidneys in a New Kidney Allocation Era.
A. Rahnemai-Azar,¹ J. Perkins,¹ A. Limaye,² N. Leca,³ C. Blosser,³ C. Johnson,³ S. Morrison,¹ R. Bakthavatsalam,¹ L. Sibulesky.¹
¹Abdominal Organ Transplantation, University of Washington Medical Center, Sattle, WA; ²Transplant Infectious Disease, University of Washington Medical Center, Sattle, WA; ³Transplant Nephrology, University of Washington Medical Center, Seattle, WA
Background: In 2014, the Organ Procurement and Transplantation Network (OPTN) approved a new kidney allocation system (KAS). One of the intended goals of this system…