ATC Abstracts

American Transplant Congress abstracts

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  • 2017 American Transplant Congress

    Pediatric Liver Transplantation for Alpha-1 Antritrypsin Deficiency: A UNOS Database Analysis.

    J. Jossen,1 R. Annunziato,2 J. McShane,2 J. Chu,1 R. Arnon.1

    1Department of Pediatrics, Mount Sinai Hospital, New York, NY; 2Psychology, Fordham University, Bronx, NY

    PurposeAlpha-1 Antritypsin Deficiency (ATD) is a heterogeneous disease, and is an important indication for liver transplantation (LT) in children. We examine the ATD population requiring…
  • 2017 American Transplant Congress

    Xenogeneic Lung Transplantation: Identifying Transgenes and Supportive Drug Treatments to Achieve Long-Term Survival.

    L. Burdorf,1 C. Laird,1 N. O'Neill,1 T. Zhang,1 D. Parsell,1 I. Tatarov,1 A. Cimeno,2 S. Sendil,1 K. Thomas,1 C. Phelps,2 D. Ayares,2 A. Azimzadeh,1 R. Pierson III.1

    1Surgery, University of Maryland, Baltimore, MD; 2Revivicor, Inc., Blacksburg, VA

    Purpose: Recent progress in genetic engineering has facilitated generation of pigs expressing various multi-transgene and knock-out combinations. Which transgenes and what targeted drug treatments are…
  • 2017 American Transplant Congress

    Blood Tfh Cells Exhibit Impaired B Cell Help in Operationally Tolerant Patients.

    R. Danger,1 A. Chenouard,1 M. Chesneau,1 S. Castagnet,2 P. Guérif,1 N. Degauque,1 M. Giral,1 S. Brouard.1

    1Inserm UMR 1064, Nantes University Hospital, Nantes, France; 2HLA Laboratory, Etablissement Français du Sang, Nantes, France

    Introduction: Operationally tolerant (TOL) patients display a defect of B cell differentiation, with a deficiency in circulating plasma cells secreting antibodies, which could partly contribute…
  • 2017 American Transplant Congress

    Impact of Serum EDTA Treatment on Identification of Unacceptable Antigens for Kidney Transplant Candidates.

    J. Xin, N. Brown, R. Upchurch, J. Weidner, S. Marino.

    Pathology, University of Chicago Medicine, Chicago, IL

    BACKGROUND AND AIMS: The prozone effect is one factor causing false negative reactions in HLA antibody testing. EDTA, which is commonly used to remove this…
  • 2017 American Transplant Congress

    Online Patient Resources for Deceased Donor and Live Donor Kidney Recipients: A Comparative Analysis of Readability.

    E. Zhou, E. Kiwanuka, W. Cioffi, P. Morrissey.

    Department of General Surgery and Division of Organ Transplantation, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, RI

    BackgroundThe Internet has extensive online resources for kidney transplantation recipients. However, it is unclear if these materials are comprehensible for kidney transplant patients. Nearly, one-half…
  • 2017 American Transplant Congress

    Disparities in Access to the Liver Transplant Wait List: A Statewide Analysis.

    Y. Bababekov, D. Chang, Y.-C. Hung, J. Adler, S. Stapleton, J. Markmann, H. Yeh.

    Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA

    Background:Racial disparities in access to the liver transplant wait list for patients with end-stage liver disease (ESLD) are thought to be attributable to differences in…
  • 2017 American Transplant Congress

    Opioid and Opioid Substitution Therapy in Liver Transplant Candidates: A Survey of Center Policies and Practices.

    J. Fleming,1 J. Lai,3 H. Te,2 A. Said,4 E. Spengler,4 S. Rogal.5

    1MUSC, Charleston, SC; 2UCSF, San Francisco, CA; 3UCMC, Chicago, IL; 4UWSMPH and VA, Madison, WI; 5Pittsburgh VA, Pittsburgh, PA

    Background: Chronic opioid use for pain and opioid substitution therapy (OST) are common among patients with cirrhosis. Little is known of transplant center policies and…
  • 2017 American Transplant Congress

    Photopheresis for Recalcitrant Rejection After Heart Transplantation: Worthwhile?

    J. Patel, M. Kittleson, X. Zhang, E. Klapper, T. Aintablian, K. Murayama, L. Czer, D. Geft, D. Chang, J. Kobashigawa.

    Cedars-Sinai Heart Institute, Los Angeles

    Background: Rejection is leading cause of mortality after heart transplantation (HTx). While the rates of rejection have declined over the past few decades from improvement…
  • 2017 American Transplant Congress

    Time to First Therapeutic Tacrolimus Level: What Impact Does It Have After Heart Transplantation?

    O. Witkowsky, J. Teuteberg, C. Sciortino, M. Shullo.

    University of Pittsburgh Medical Center, Pittsburgh, PA

    Purpose: Appropriate time to therapeutic immunosuppression levels is not well defined. The purpose of this study is to investigate outcomes related to time to therapeutic…
  • 2017 American Transplant Congress

    Platelets Stimulate Liver Sinusoidal Endothelial Cells to Secrete Interleukin-6 During the Early Phase of Liver Regeneration in Mice.

    J. Meyer,1,2 E. Perroud,2 P. Fontana,3,4 K. Sadoul,5 P. Morel,1,2 C. Gonelle-Gispert,2 L. Bühler.1,2

    1Division of Digestive and Transplantation Surgery, University Hospitals of Geneva, Geneva, Switzerland; 2Unit of Surgical Research, University of Geneva, Geneva, Switzerland; 3Division of Angiology and Haemostasis, University Hospitals of Geneva, Geneva, Switzerland; 4Geneva Platelet Group, University of Geneva, Geneva, Switzerland; 5Institute for Advanced Biosciences, Inserm U1209, Grenoble, France

    Background and aimsPlatelets and liver sinusoidal endothelial cells (LSEC) are known to both independently regulate liver regeneration. Our aim was to investigate the role of…
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