Am J Transplant, Volume 17, Suppl 3 Archives - Page 42 of 181 - ATC Abstracts

2017 American Transplant Congress
Safety and Activity of Anti-C1s Humanized Monoclonal Antibody TNT009 in Late Antibody-Mediated Kidney Allograft Rejection – Results of a First-in-Human Phase 1 Trial.
F. Eskandary,¹ B. Jilma,² J. Muehlbacher,³ M. Wahrmann,¹ H. Regele,⁴ N. Kozakowski,⁴ S. Panicker,⁵ J. Reeve,⁶ P. Halloran,⁶ J. Gilbert,⁵ G. Bohmig.¹
¹Department of Medicine III, Medical University Vienna, Vienna, Austria; ²Department of Clinical Pharmacology, Medical University Vienna, Vienna, Austria; ³Department of Surgery, Medical University Vienna, Vienna, Austria; ⁴Department of Clinical Pathology, Medical University Vienna, Vienna, Austria; ⁵True North Therapeutics Inc., San Frnacisco; ⁶Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, Canada
Study purpose:The classical pathway (CP) of complement may significantly contribute to antibody-mediated rejection (ABMR). Blockade of CP key component C1 may be a promising strategy…
2017 American Transplant Congress
Antibodies Specific for HLA Class I and Lung Associated Self-Antigens, Kα1Tubulin and Collagen V, Induces Exosomes Following In Vitro Binding to Human Airway Epithelial Cells.
M. Gunasekaran, M. Sharma, S. Bansal, S. Biswas Roy, R. Walia, M. Smith, R. Bremner, T. Mohanakumar.
Norton Thoracic Institute, St. Joseph's Hospital and Med Center, Phoenix
Background: It is generally accepted that antibody (Ab) binding to its specific antigen, in addition to activating complement pathway, can induce intracellular signals leading to…
2017 American Transplant Congress
A Humanized Anti-CD47 Monoclonal Antibody Therapy Alleviates Ischemia-Reperfusion Injury of Porcine Renal Allografts Donated After Cardiac Death.
M. Xu,¹ B. Banan,¹ X. Wang,¹ D. Chirumbole,¹ B. Rabe,¹ S. Garcia-Aroz,¹ D. Nayak,¹ Z. Zhang,¹ J. Jia,¹ G. Upadhya,¹ J. Gaut,² P. Manning,³ Y. Lin,¹ W. Chapman.¹
¹Department of Surgery, Washington University School of Medicine, St. Louis; ²Department of Pathology and Immunology, Washington University School of Medicine, St. Louis; ³Tioma Therapeutics, Inc, St. Louis
PURPOSE: This study investigated whether the blockade of the CD47 signaling pathway, which is involved in vascular endothelial nitric oxide regulation, reduces ischemia-reperfusion injury (IRI)…
2017 American Transplant Congress
Fosfomycin Tromeltamol (FOS) Is an Effective Alternative in Post Renal Transplant Urinary Tract Infection Prophylaxis Caused by Escherichia coli and Enterococcus faecalis without Increasing Resistance Rate.
J. Arreola-Guerra,¹ J. Alberu,² L. Morales-Buenrostro,² E. Maravilla,³ R. Rosado,³ J. Sifuentes.³
¹Nephrology and Transplantation, Centenario Hospital Miguel Hidalgo, Aguascalientes, Mexico; ²Transplantation, Instituto Nacional de Nutrición Salvador Zubirán, Mexico, Mexico; ³Medicine, Instituto Nacional de Nutrición Salvador Zubirán, Mexico, Mexico
Urinary tract infection (UTI) is one of the most important complications in renal transplant recipients (rTR) during the first year after renal transplantation (RT). Antimicrobial…
2017 American Transplant Congress
The Associations Between Body Mass Index and Kidney Transplant Outcomes Are Mediated by Weight-Adjusted Immunosuppression Dosing.
K. Flabouris,^1,2 S. Chadban,^1,3,4 M. Ladhani,^1,3,5 M. Cervelli,⁶ P. Clayton.^1,2,6
¹Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry, Adelaide, Australia; ²School of Medicine, University of Adelaide, Adelaide, Australia; ³Sydney Medical School, University of Sydney, Sydney, Australia; ⁴Department of Renal Medicine, Royal Prince Alfred Hospital, Sydney, Australia; ⁵Department of Renal Medicine, Lyell McEwin Hospital, Adelaide, Australia; ⁶Central Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, Australia
Purpose: High body mass index (BMI) is associated with acute rejection after kidney transplantation. We hypothesised that weight-adjusted immunosuppression dosing is a contributing factor. We…
2017 American Transplant Congress
A Donor BMI Greater Than 30 Is Not a Contraindication for Live Liver Donation.
N. Goldaracena, A. Doyle, D. Al-Adra, G. Sapisochin, M. Cattral, P. Greig, L. Lilly, I. McGilvray, A. Ghanekar, D. Grant, N. Selzner, M. Selzner.
Toronto General Hospital, University of Toronto, Toronto, Canada
Background & aims: The increased prevalence of obesity worldwide threatens the pool of potential living liver donors. While the negative effects of graft steatosis on…
2017 American Transplant Congress
Vital Role of the CoREST Complex as a Master Regulator of Foxp3+ T-Regulatory Cell Gene Expression and Suppressive Function.
L. Wang,¹ A. Samanta,¹ M. Levine,¹ U. Beier,¹ R. Han,¹ J. Kalin,² E. Holson,³ P. Cole,² W. Hancock.¹
¹Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; ²Johns Hopkins University, Baltimore, MD; ³Broad Institute, Cambridge, MA
While the Foxp3 promoter and its three associated conserved non-coding sequence (CNS)/enhancer regions have received much attention, literally nothing is known of the contribution of…
2017 American Transplant Congress
Inferior Graft and Patient Survival After Living Donor Renal Transplantation of Negatively Selected Right Kidneys.
S. Yamanaga,^1,2,3 A. Posselt,¹ C. Freise,¹ C. Niemann,¹ A. Rosario,¹ D. Fernandez,¹ T. Kobayashi,³ A. Ahearn,⁴ M. Tavakol,¹ S.-M. Kang.¹
¹Department of Surgery, UCSF, San Francisco, CA; ²Department of General Surgery, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan; ³Department of Renal Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan; ⁴Department of Transplant Surgery, UMass Memorial Medical Center, Worcester, MA
Purpose: In living donor renal transplantation, the left kidney is usually chosen for anatomical reasons. The right kidney is sometimes chosen if it is believed…
2017 American Transplant Congress
Reassessing Thymoglobulin Induction in Kidney Transplantation (RETHINK): An Analysis of the North American Pediatric Renal Trials and Collaborative Studies (NAPRTCS) Registry.
I. Ashoor,¹ K. Martz,² R. Beyl,³ V. Dharnidharka.⁴
¹Children's Hospital, New Orleans, LA; ²EMMES Corporation, Rockville, MD; ³Pennington Biomedical Research Center, Baton Rouge, LA; ⁴Washington University, St. Louis, MO
There is no consensus on Thymoglobulin (TMG) dose used for induction immunosuppression (IS) in pediatric kidney transplants (KTx). We aimed to identify: 1) TMG induction…
2017 American Transplant Congress
Elevated Donor HbA1C Confers Impaired Overall Survival Following Renal Allotransplantation in Recipients of Allografts from Donors with Diabetes Mellitus: A National Analysis.
M. Mulvihill, B. Yerokun, R. Davis, A. Barbas, M. Hartwig.
Surgery, Duke University Medical Center, Durham, NC
Introduction: Donor diabetes mellitus (DM) is a risk factor for impaired outcomes following renal transplant. Donor DM is factored into the Kidney Donor Risk Index…