Am J Transplant, Volume 17, Suppl 3 Archives - Page 39 of 181 - ATC Abstracts

2017 American Transplant Congress
Facing Unintended Challenges of Increased Risk Donor Kidneys in a New Kidney Allocation Era.
A. Rahnemai-Azar,¹ J. Perkins,¹ A. Limaye,² N. Leca,³ C. Blosser,³ C. Johnson,³ S. Morrison,¹ R. Bakthavatsalam,¹ L. Sibulesky.¹
¹Abdominal Organ Transplantation, University of Washington Medical Center, Sattle, WA; ²Transplant Infectious Disease, University of Washington Medical Center, Sattle, WA; ³Transplant Nephrology, University of Washington Medical Center, Seattle, WA
Background: In 2014, the Organ Procurement and Transplantation Network (OPTN) approved a new kidney allocation system (KAS). One of the intended goals of this system…
2017 American Transplant Congress
Intended and Unexpected Impact of the New Kidney Allocation System on a Large Volume Transplant Program.
A. de Mattos, M. Alnimri, L.-X. Chen, J. Sageshima, C. Santhanakrishnan, R. Perez.
University of California Davis, Sacramento, CA
On December 4, 2014 the new Kidney Allocation System (KAS) went into effect in the United States. The intentions of KAS were to increase the…
2017 American Transplant Congress
T Cell Responses to Viral Peptide Stimulation Predict Influenza Vaccine-Induced Seroconversion in Pediatric Solid Organ Transplant Recipients.
E. Mayer,¹ M. Altrich,² C. Cordes,² S. Fausett,² J. Tepp,³ R. Albrecht,³ A. Fernandez-Sesma,³ B. Herold,¹ I. Ramos,³ R. Madan.¹
¹Pediatrics, Albert Einstein College of Medicine, Bronx, NY; ²Viracor Eurofins, Lee's Summit, MO; ³Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY
Introduction: Biomarkers predictive of vaccine response are needed to determine the optimal timing of immunization post-transplantation. We previously found that low T-cell ELISPOT responses to…
2017 American Transplant Congress
Dexamethasone Prolongs Cardiac Allograft Survival in a Murine Model Through Myeloid-Derived Suppressor Cells.
T. Nakao,¹ T. Nakamura,¹ K. Masuda,¹ T. Matsuyama,¹ H. Ushigome,¹ E. Ashihara,² N. Yoshimura.¹
¹Organ Transplantation and Regenerative Surgery, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan; ²Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan
Recently, myeloid-derived suppressor cells (MDSCs) have attracted considerable attention because of their cancer-promoting and immunosuppressive effects. The glucocorticoid (GC) dexamethasone (Dex) is an important immunosuppressive…
2017 American Transplant Congress
A Promising MyD88 Inhibitor TJ-M2010-2 Protects Heart from Myocardial Ischemia Reperfusion Injury.
Y. Miao, L. Xie, X. Zhang, Z.-C. Ding, M. Yang, Y. Yang, P. Zhou.
Institute of Qrgan Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Key Labrory of Organ Transplantation, Wuhan, Hubei, China
BACKGROUND: The activation of innate immunity via myeloid differentiation factor 88 (MyD88) contributes to myocardial ischemia reperfusion injury (IRI). This study is to investigate the…
2017 American Transplant Congress
On the Pathogenesis of Post-Transplant Diarrhea in Kidney Transplant Recipients.
J. Lee,¹ M. Mcgruder,¹ L. Zhang,¹ M. Thangamani,¹ D. Dadhania,¹ L. Westblade,¹ M. Satlin,¹ A. Robertson,² L. Ling,² Y. Taur,² E. Pamer,² M. Suthanthiran.¹
¹Medicine, Weill Cornell, NY, NY; ²Medicine, Memorial Sloan Kettering Cancer Center, NY, NY
Introduction. Post-transplant diarrhea is a frequent complication after kidney transplantation but its etiology is unknown in the majority of cases; herein, we investigated whether post-transplant…
2017 American Transplant Congress
Kidney Allocation Using CMV Matching Optimizes Low and High Risk Profiles for Prevention of CMV Infection in Kidney Transplant Recipients.
J. Lockridge,¹ E. Langewisch,² D. Basuli,¹ A. Olyaei,³ C. Shaut,⁴ D. Norman.¹
¹Division of Nephrology, Department of Medicine, Oregon Health and Science University, Portland, OR; ²Nephrology, University of Nebraska, Omaha, NE; ³Pharmacy, Oregon Health and Sciences University, Portland, OR; ⁴Immunogenetics and Transplant, Oregon Health and Sciences University, Portland, OR
Cytomegalovirus (CMV) confers a major impact on morbidity, mortality, and graft survival in kidney transplant recipients. Efforts to prevent CMV disease and infection have traditionally…
2017 American Transplant Congress
Down but Not Out: Leucopenia Can Be Safely Treated with Reduction in Immunosuppression without Increasing Risk to the Kidney Allograft.
A. Gilbert,¹ A. Vergottini,¹ A. Karabala,¹ M. Grafals,¹ B. Javaid,¹ J. Moore,¹ J. Verbesey,² P. Abrams,² S. Ghasemian,² M. Cooper.²
¹Department of Medicine, Medstar Georgetown Transplant Institute, Washington, DC; ²Department of Surgery, Medstar Georgetown Transplant Institute, Washington, DC
IntroductionLeucopenia is a growing problem with increasing immunosuppression (IS) in kidney transplantation. Reducing IS in the face of leucopenia is a concern due to the…
2017 American Transplant Congress
Treatment and Outcomes of Simultaneous Acute Rejection and Polyomavirus Allograft Nephropathy.
T. Sparkes, S. Hammad, C. Drachenberg, A. Haririan.
University of Maryland, Baltimore, MD
Background: Reduction of immunosuppression for polyomavirus allograft nephropathy (PVAN) is associated with risk of acute rejection (AR), and in uncommon cases both are present together…
2017 American Transplant Congress
Retroactive Application of a New Risk Index for Living Donor Kidney Transplantation (LKDPI) to Renal Transplants in Veracruz, Mexico.
G. Martinez-Mier,^1,2 E. Soto-Miranda,¹ S. Avila-Pardo,² L. Budar-Fernandez,¹ M. Mendez-Lopez,¹ P. Moreno-Ley,¹ E. Aguilar-Sandoval,¹ G. Coello-Torres,³ F. Diaz-Trueba.³
¹Organ Transplantation, IMSS UMAE HE 14, Veracruz, Mexico; ²Organ Transplantation, HRAEV, Veracruz, Mexico; ³Research, IMSS UMAE HE 14, Veracruz, Mexico
Kidney Donor Profile Index (KDPI) was designed to estimate the graft loss risk in deceased donor transplants. Recently, the Epidemiology Research Group for Organ Transplantation…