Am J Transplant, Volume 17, Suppl 3 Archives - Page 37 of 181 - ATC Abstracts

2017 American Transplant Congress
Largest US Series of Minimally Invasive Full and Laparoscopy-Assisted Living Donor Hepatectomy.
K. Collins, J. Emond, A. Fox, B. Samstein.
Surgery, New York Presbyterian/Columbia University, New York, NY
Columbia University Medical Center (CUMC) has offered minimally invasive donor hepatectomies since 2008. Donor hepatectomies have been performed using 3 access routes (1) hybrid technique;…
2017 American Transplant Congress
Utility of IL-2 Complexes in Promoting Vascularized Composite Allograft Survival.
H. Xu,¹ S. Dahiya,² L. Wang,² T. Akimova,² W. Hancock,^2,4 S. Levin.³
¹Plastic and Reconstructive Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; ²Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia; ³Orthopaedic Surgery, Hospital of the University of Pennsylvania, Philadelphia; ⁴Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia
Vascularized composite allografts (VCA) are a novel, life-enhancing form of transplantation (Tx). The complexity of host immune responses to VCA tissues, especially those involving skin,…
2017 American Transplant Congress
Specific Gene Expression Signature of Complement-Activating Donor Specific Anti-HLA Antibody-Mediated Rejection in Kidney Allografts.
C. Lefaucheur,¹ D. Viglietti,¹ L. Hidalgo,² O. Aubert,¹ A. Zeevi,³ P. Halloran,² A. Loupy.¹
¹Paris Translational Research Center for Organ Transplantation, Paris, France; ²University of Alberta, Edmonton, Canada; ³University of Pittsburgh Medical Center, Pittsburgh
Complement-binding anti-HLA DSA have demonstrated higher rejection rate and decreased allograft survival. However, their specific effects on rejection pathogenesis have not been identified. We investigated…
2017 American Transplant Congress
Assessment of Simple Indices Based on a Single Fasting Blood Sample in Search for an Optimal Tool to Estimate Beta Cell Function After Islet Transplantation.
J. Golebiewska,¹ J. Solomina,² E. Konsur,² K. Cieply,² L. Basto,² A. Kotukhov,² K. Golab,² C. Thomas,³ A. Debska-Slizien,¹ P. Witkowski.²
¹Department of Nephrology, Medical University of Gdansk, Gdansk, Poland; ²Departemt of Surgery, University of Chicago, Chicago; ³Department of Medicine, University of Chicago, Chicago
Background:Precise yet logistically feasible evaluation of beta-cell function is extremely important after islet allotransplantation. We investigated the utility and possible limitations of indices using only…
2017 American Transplant Congress
Donor Recipient Matching Based on HLA Epitopes Improves Outcome in Kidney Transplant Recipients.
O. Staeck,¹ M. Niemann,³ F. Halleck,¹ D. Khadzhynov,¹ C. Schönemann,² P. Reinke,¹ E. Spierings,⁴ K. Budde,¹ N. Lachmann.²
¹Nephrology, Charité Universitaetsmedizin, Berlin, Germany; ²HLA Laboratory, Charité Universitaetsmedizin, Berlin, Germany; ³PIRCHE, Berlin, Germany; ⁴Laboratory of Translational Immunology, UMC Utrecht, Utrecht, Netherlands
Background: HLA mismatches of the donor and recipient causing de novo donor-specific HLA antibodies (dnDSA) are a risk factor for immunologic complications and poor graft…
2017 American Transplant Congress
Gut Microbial Metabolite Improves Function and Prolongs Kidney Allograft Survival in Mice.
H. Wu,^1,2 T. Kwan,¹ Y. Loh,¹ X. Chen,¹ L. Macia,^2,3 S. Alexander,^2,4 S. Chadban.^1,2
¹Kidney Node Laboratory, The Charles Perkins Centre and Renal Medicine, Sydney Medical School and Royal Prince Alfred Hospital, Sydney, Australia; ²University of Sydney, Sydney, Australia; ³Nutritional Immunometabolism Lab, The Charles Perkins Centre, Sydney Medical School, Sydney, Australia; ⁴Nephrology Department, The Children Hospital at Westmead, Sydney, Australia
To determine the impact of dietary administration of the gut microbial metabolite sodium acetate (SA) on kidney rejection and survival in a fully MHC-mismatched murine…
2017 American Transplant Congress
Effect of Preformed Donor-Specific Antibodies in Intestine/Multivisceral Transplantation.
M. Safwan,¹ M. Rizzari,¹ K. Collins,¹ A. Yoshida,¹ S. Skorupski,² O. Fagoaga,² M. Abouljoud,¹ S. Nagai.¹
¹Divison of Transplant and Hepatobiliary Surgery, Henry Ford Transplant Institute, Detroit, MI; ²Transplant Immunology, Henry Ford Hospital, Detroit, MI
Aim: To analyze the effect of preformed donor-specific antibodies (DSA) in intestine/multivisceral transplantation patients.Methods: Retrospective review of preformed and de novo DSAs of all intestine/multivisceral…
2017 American Transplant Congress
CD28 Directed Immunotherapy Is More Potent Than Belatacept in a Nonhuman Primate Xenotransplant Model.
S. Kim,¹ L. Higginbotham,¹ D. Mathews,¹ C. Breeden,¹ A. Stephenson,¹ C. Larsen,¹ M. Ford,¹ J. Tector,² A. Adams.¹
¹Emory Transplant Center, Emory University, Atlanta, GA; ²University of Alabama Birmingham, Birmingham, AL
Introduction. Xenotransplantation may alleviate the organ shortage, yet experimental renal xenotransplantation has met limited success. T cell-mediated damage remains a critical problem. Our group has…
2017 American Transplant Congress
How to Improve Pre-Kidney Transplant Education for Hispanics: Preferences and Perceptions of Northwestern Memorial Hospital's Hispanic Transplant Program.
H. Gomez, E. Malagon-Blackwell, J. Caicedo.
The Comprehensive Transplantation Center, Northwestern University Feinberg School of Medicine, Chicago, IL
Context: Pre-Transplant educational sessions improve access to transplantation. Currently, however, there is lack of culturally competent approaches to improve living kidney donation for Hispanics Americans.…
2017 American Transplant Congress
Long-Term Drug-Free Survival of Tiny Cynomolgus Islet Allografts.
M. Koulmanda, V. Chipashivili, M. Duggan, T. Strom.
Surgery and Medicine, Beth Israel Deaconess Medical Center, Boston, MA; Surgery, Massachusetts General Hospital, Boston, MA
Following upon highly beneficial effects observed with short-term alpha 1-antitrypsin (AAT) treatment in the marginally sized autologous cynomolgus islet transplant model, we are testing the…