ATC Abstracts

American Transplant Congress abstracts

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  • 2017 American Transplant Congress

    The Impact of Delayed Graft Function on Long Term Graft Survival Adjusted for Donor Kidney Quality Assessed by the KDPI.

    L. Lehner, F. Halleck, D. Khadzhynov, E. Schrezenmeier, M. Dürr, K. Budde, O. Staeck.

    Nephrology Charite Campus Mitte, Charite Universitaetsmedizin Berlin, Berlin, Germany

    IntroductionDelayed graft function (DGF) is associated with impaired graft survival in kidney transplant recipients. The kidney donor profile index (KDPI) is increasingly evaluated as a…
  • 2017 American Transplant Congress

    Determinants of Severe Interstitial Fibrosis in Kidney Allografts: Major Impact of Circulating Donor-Specific Anti-HLA Antibodies.

    C. Gosset, D. Viglietti, M. Rabant, E. Pillebout, J. Taupin, D. Glotz, C. Legendre, J. Duong Van-Huyen, A. Loupy, C. Lefaucheur.

    Paris Translational Research Center for Organ Transplantation, Paris, France

    Interstitial fibrosis represents a major cause of kidney allograft failure. We investigated the independent contribution of circulating donor-specific anti-HLA antibodies (DSA) in the development of…
  • 2017 American Transplant Congress

    Donor-Derived Nonclassical Monocytes Produce MIP-2 to Recruit Recipient Neutrophils and Cause Ischemia Reperfusion Injury After Lung Transplant.

    S. Chiu,1 Z. Zheng,1 M. Akbarpour,1 R. Fernandez,1 A. McQuattie-Pimentel,1 P. Reyfman,1 K. Anekalla,1 D. Kreisel,2 H. Perlman,1 G. Budinger,1 A. Misharin,1 A. Bharat.1

    1Northwestern University, Chicago; 2Washington University, St Louis

    Purpose: Primary graft dysfunction (PGD), the primary cause of early mortality after lung transplant, is mediated by neutrophils. However, neutrophil depletion may not be clinically…
  • 2017 American Transplant Congress

    Blood and Biopsy Genomic Signatures of Acute Rejection in Liver Transplant Recipients.

    J. Levitsky,1 T. Whisenant,2 S. Kurian,2 S. Rao,1 A. Demetris,3 M. Abecassis.1

    1Northwestern, Chicago; 2The Scripps Research Institute, San Diego; 3University of Pittsburgh, Pittsburgh

    Background: Biomarker profiles diagnostic of acute rejection (AR) could enhance the diagnosis and management of liver transplant (LT) recipients. Our aim was to identify diagnostic…
  • 2017 American Transplant Congress

    Complement Binding Activity (C3d, C1q) of De Novo Donor-Specific HLA Antibody Is Associated with Increased Risk of Antibody-Mediated Rejection in Non-Sensitized Kidney Transplant Recipients.

    H. Lee,1 E. Han,1 A.-R. Choi,1 K. Park,2 J. Ryu,2 B. Chung,3 C. Yang,3 E.-J. Oh.1

    1Laboratory Medicine, The Catholic University of Korea, Seoul, South Korea (KOR), Korea; 2Biomedical Science, Graduate School, The Catholic University of Korea, Seoul, South Korea (KOR), Korea; 3Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea, Seoul, South Korea (KOR), Korea

    Despite advances in therapeutic strategies and medicine, antibody mediated rejection (AMR) is a leading cause of kidney graft loss. The complement binding activity of donor-specific…
  • 2017 American Transplant Congress

    Comparison Between IgG, C1q and C3d Single Antigen Bead Assays in Detecting Class I Complement-Binding Anti-HLA Antibodies.

    M. Moreno Gonzales,1 D. Mitema,2 B. Smith,3 C. Schinstock,3 M. Stegall,3 M. Gandhi.3

    1Servicio de Cirugía General, Clínica Anglo Americana, Lima, Peru; 2Division of Nephrology, Mississippi Baptist Medical Center, Jackson, MS; 3Transplant Center, Mayo Clinic, Rochester, MN

    Introduction. Donor specific antibodies (DSA) are associated with an increased risk of chronic antibody mediated rejection (CAMR). DSA characterization by single antigen bead (SAB) assays…
  • 2017 American Transplant Congress

    PTEN Inhibition in MSC Upregulates PD-L1 and Enhances Their Immunomodulatory Capacity Prolonging Skin Allograft Survival.

    M. Climov, M. Uehara, Z. Solhjou, H. Matsumine, N. Bouyani, E. Kefaloyianni, B. Basmani, V. Kasinath, G. Giatsidis, D. Orgill, R. Abdi.

    Brigham and Women's Hospital, Boston, MA

    Due to lack of autologous and donor site morbidity, there is a distinct clinical need to increase the utility of skin allografts by improving their…
  • 2017 American Transplant Congress

    Effect of Induction Therapy in ABO Incompatible Living-Donor Kidney Transplantation: A Single Center Experience.

    L. Lanfranco, L. Esposito, A. Del Bello, O. Cointault, A. Allal, L. Rostaing, N. Kamar.

    Department of Nephrology and Organ Transplantation, Toulouse University Hospital, Toulouse, France

    Due to the shortage in organs, ABO incompatible (ABOi) living-donor kidney transplantation (LDKT) was developed. Herein, we report on our single center experience and assess…
  • 2017 American Transplant Congress

    A New Strategy for Loco-Regional Therapy of Hepatocellular Carcinoma: Stereotactic Body Radiotherapy as a Bridge to Liver Transplantation.

    T. Uemura,1 A. Kirichenko,2 M. Bunker,3 M. Vincent,1 L. Machado,1 A. Singhal,1 N. Thai.1

    1Transplant Surgery, Allegheny General Hospital, Pittsburgh; 2Radiation Oncology, Allegheny General Hospital, Pittsburgh; 3Pathology, Allegheny General Hospital, Pittsburgh

    Background: Transarterial chemoembolization (TACE) or radiofrequency ablation are often used as local Hepatocellular Carcinoma (HCC) treatment while waiting for a liver transplant (LTx). However, it…
  • 2017 American Transplant Congress

    The American Transplant Congress Effect on Kidney Discard Rates in the United States.

    D. Abdelwahab,1 G. Wei,2 I. Hall.2

    1Mayo Clinic, Scottsdale, AZ; 2University of Utah, Salt Lake City, UT

    Background: Deceased-donor kidneys with high kidney donor risk index (KDRI) are often discarded despite evidence that certain candidates would have better survival accepting these kidneys…
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