2017 American Transplant Congress
Ectopic Lymphoid Structures Are Present in Type I T-Cell Mediated Kidney Transplant Rejection.
BackgroundIn renal transplantation, many allograft recipients develop donor-specific antibodies associated with an increased risk for graft rejection. Current immunosuppressive agents are principally aimed at T-cell-mediated…2017 American Transplant Congress
Relationship Between Mixed Chimerism and Tolerance in HLA-Matched and -Mismatched Recipients of Kidney and Hematopoietic Cell Transplants.
Twenty-eight fully HLA-matched and 18 HLA haplotype- matched recipients were given combined kidney and hematopoietic cell transplants using a completely post-transplant conditioning regimen consisting of…2017 American Transplant Congress
A Proof of Concept for Liver Graft Modification Using Warm Ex Vivo Perfusion – “It Is Not Just About Rescuing Marginal Grafts”.
Toronto General Hospital, University of Toronto, Toronto, Canada
Background: The active metabolism during normothermic ex vivo liver perfusion (NEVLP) offers a new opportunity to use the preservation time for graft modification and repair…2017 American Transplant Congress
Mutations in Influenza A Virus and Clinical Implications in Transplant Recipients.
1UHN, Toronto, Canada; 2REIPI, Seville, Spain; 3UPenn, Philadelphia; 4LUMC, Leiden, Netherlands
Background: Organ and hematopoietic stem cell transplant (HSCT) recipients are predisposed to complications of influenza infection and as such may constitute an important source of…2017 American Transplant Congress
Prescription Opioid Use Before and After Kidney Transplant: Implications for Post-Transplant Outcomes.
We previously identified associations of opioid use before kidney transplant (KTx) with post-KTx complications.To confirm and extend these findings, we examined a novel database wherein…2017 American Transplant Congress
Analysis of Differences in Living Donor and Recipient Pairs Estimated GFR at Six Months Over Time.
Medicine, Division of Nephrology, Sacred Heart Hospital, Pensacola, FL
Previous studies of the United States Kidney Transplant Database revealed that the median estimated GFR (eGFR) has improved over the last decade for living donor…2017 American Transplant Congress
First Report of Human Liver Transplantation After Normothermic Machine Perfusion (NMP) in the United States.
NMP is a novel preservation method for liver grafts. We transplanted 10 human livers after NMP to test the safety and feasibility of NMP on…2017 American Transplant Congress
Safety and Activity of Anti-C1s Humanized Monoclonal Antibody TNT009 in Late Antibody-Mediated Kidney Allograft Rejection – Results of a First-in-Human Phase 1 Trial.
Study purpose:The classical pathway (CP) of complement may significantly contribute to antibody-mediated rejection (ABMR). Blockade of CP key component C1 may be a promising strategy…2017 American Transplant Congress
Antibodies Specific for HLA Class I and Lung Associated Self-Antigens, Kα1Tubulin and Collagen V, Induces Exosomes Following In Vitro Binding to Human Airway Epithelial Cells.
Norton Thoracic Institute, St. Joseph's Hospital and Med Center, Phoenix
Background: It is generally accepted that antibody (Ab) binding to its specific antigen, in addition to activating complement pathway, can induce intracellular signals leading to…2017 American Transplant Congress
A Humanized Anti-CD47 Monoclonal Antibody Therapy Alleviates Ischemia-Reperfusion Injury of Porcine Renal Allografts Donated After Cardiac Death.
PURPOSE: This study investigated whether the blockade of the CD47 signaling pathway, which is involved in vascular endothelial nitric oxide regulation, reduces ischemia-reperfusion injury (IRI)…
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