2017 American Transplant Congress
The Gut Microbiota Regulates Murine Cardiac Transplant Outcome.
Background: Gut microbiota regulates systemic immunity and can activate pro- or anti-inflammatory pathways. We hypothesized that the gut microbiota influences the survival of mismatched murine…2017 American Transplant Congress
MHC Class II-Peptide Complexes Displayed on Activated T Cells Guide Treg Suppression.
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
Background: Regulatory T cell (Tregs) therapy remains a promising strategy for minimizing immunosuppression and extending allograft survival. Although Treg suppression requires initial activation through cell…2017 American Transplant Congress
Gene Expression Profiling for the Identification and Classification of Antibody-Mediated Heart Rejection.
Antibody-mediated rejection (AMR) is a major determinant of heart allograft loss. However, the specific effects of anti-HLA antibodies on heart allograft injury have not been…2017 American Transplant Congress
Impact of Donor BK-Virus Replication on Posttransplant BKV Replication After Living-Donor Transplantation.
Department of Nephrology and Organ Transplantation, Toulouse University Hospital, Toulouse, France
BK-virus-associated nephropathy (BKVAN) can cause kidney-allograft dysfunction after kidney transplantation: several risk factors for BKV replication after kidney transplantation have been identified. They can be…2017 American Transplant Congress
Cardiovascular Events Are a Substantial and Increasing Cause of Graft Loss in Liver Transplant Recipients.
Pharmacy, Transplant, MUSC, Charleston, SC
Purpose: The overall 1- and 3- year graft survival rates following liver transplant are 89.1% and 79.9%, respectively. While these numbers have vastly improved, they…2017 American Transplant Congress
Is “Death with a Functioning Graft (DWF)” Really Death with Function? Data from the Long-Term Deterioration of Kidney Allograft Function (DeKAF) Study.
To understand causes of kidney transplant (KT) failure, outcomes are often segregated into death-censored graft failure (DCGF, a proxy for immunologic injury) and DWF. To…2017 American Transplant Congress
The Impact of the New Kidney Allocation System on Length of Dialysis Prior to Transplantation.
1Emory University, Atlanta; 2Columbia University, New York
Introduction: The Kidney Allocation System (KAS) changed the starting point for calculating waiting time for patients on the kidney transplant (KTx) waitlist from the time…2017 American Transplant Congress
The Molecular Phenotypes of Rejection in Kidney Transplant Biopsies.
University of Alberta, Edmonton, AB, Canada
In a microarray analysis of 1208 kidney transplant indication biopsies, each biopsy was assigned molecular scores for seven phenotypes related to various aspects of TCMR,…2017 American Transplant Congress
Gene Expression During Development of Chronic Antibody-Mediated Rejection in Renal Allografts from Non-Human Primates: Validation of Markers Used in Humans and Sequential Changes in Protocol Biopsies.
Background: RNA transcript measurement is a promising adjunct for the diagnosis and classification of antibody-mediated rejection (ABMR), however most technologies require specially processed biopsy samples.…2017 American Transplant Congress
The Cumulative United States Experience with Transplants (Txs) from Living Donors (LDs): 140,156 LD Txs in 28 Years.
Background/Purpose: Solid organ txs from LDs provide better outcome results than from DDs. We analyzed the cumulative US LD tx experience since UNOS inception. The…
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