2017 American Transplant Congress
Commonly Expressed Living Donation Fears and Concerns by Non-Directed (Altruistic) Living Kidney Donors in the United States.
A. In the United States, many factors, including lack of awareness and misconceptions about living kidney transplantation, create challenges that limit increasing the live kidney…2017 American Transplant Congress
Human Regulatory T Cells Undergo Self-Inflicted Damage via Granzyme Pathways Upon Activation.
In this study, we investigated the mechanisms behind the activation induced cell death of human regulatory T cells (Tregs) that can explain their rapid loss…2017 American Transplant Congress
Liver Targeted Expression of a Single Allogeneic MHC I Molecule Promotes Tolerance to Pancreatic Islet Allograft by Inducing Specific CD8+ Regulatory T Cells in Mice.
A. Induction of donor-specific immune tolerance is a good alternative to chronic life-long immunosuppression for transplant patients. Donor major histocompatibility complex (MHC) molecules represent the…2017 American Transplant Congress
Identification of Promising Targets for Tolerance Induction Following Heart Transplantation.
Clinic for Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany
Introduction: Tolerance-inducing cell subsets which can support the organ acceptance following heart transplantation (HTx) can be found among dendritic cells (DCs) and regulatory T cells…2017 American Transplant Congress
Beneficial Effects of Human Mesenchymal Stromal Cells on Porcine Hepatocytes Viability and Albumin Secretion.
Aim: Acute liver failure carries a very high mortality and transplantation of encapsulated pig hepatocytes might temporarily compensate the metabolic functions until the dysfunctional liver…2017 American Transplant Congress
Assessment of C4d Positive Biopsies with No Histological Evidence of Inflammation Using Nanostring nCounter Technology.
Deposition of C4d has been an established part of the Banff classification scheme for antibody mediated rejection (AbMR) since 2001. More recently, C4d negative AbMR…2017 American Transplant Congress
Neuropeptide PACAP Prevents Hepatocyte Damage by Promoting Yes-Associated Protein (YAP) in Mouse Liver Ischemia/Reperfusion Injury.
Background: Yes-associated protein (YAP), a regulator of cellular anti-oxidation and regeneration, drives cell proliferation and promotes survival. We have previously demonstrated that neuropeptide pituitary adenylate…2017 American Transplant Congress
Everolimus Does Not Increase Risk of Delayed Graft Function or Prolong Duration of Dialysis in Renal Transplantation.
US92 (NCT01025817) is a phase III, 12 month, open-label, randomized study comparing everolimus (EVR) plus low-dose tacrolimus (LTac) vs. mycophenolate mofetil (MMF) with standard-dose tacrolimus…2017 American Transplant Congress
Alemtuzumab Induction and Belatacept Maintenance in Marginal Pathology Renal Allografts.
University of Maryland, Baltimore
Background: The potential for improved outcomes with CNI avoidance may be important for kidneys with an increased likelihood of impaired graft function. We performed a…2017 American Transplant Congress
Systemic Meta-Analysis: Is Early Conversion to mTOR Inhibitors Represent a Suitable Choice in Renal Transplant Recipients?
Aim: This meta-analysis focuses on the current evidence of renal graft functioning and graft survival following early conversion to mTOR inhibitors with or without CNI…
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