ATC Abstracts

American Transplant Congress abstracts

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  • 2017 American Transplant Congress

    Age-Related Differences in Gene Expression Among Kidney Allografts with Normal Histology and Calcineurin Inhibitor Nephrotoxicity.

    E. Rhone,1 S. Bontha,1 P. Walker,2 C. Dumur,3 D. Maluf,1 J. Almenara,3 V. Mas.1

    1University of Virginia, Charlottesville; 2Arkana Laboratories, Little Rock; 3Virginia Commonwealth University, Richmond

    Background Most biomarker research first occurs in adult populations, with consequent extrapolation to children. However, age-related differences may impact gene expression, such as variations in…
  • 2017 American Transplant Congress

    Patient Outcomes Following the Disappearance of Donor Specific Antibody in Crossmatch Positive Simultaneous Liver-Kidney Transplant Recipients.

    P. Jindra,1 G. Stacie,1 A. Rana,2 C. O'Mahony,2 J. Goss,2 M. Bhamidipati,2 E. Whiston,3 R. Kerman.1

    1Michael E. DeBakey Department of Surgery Division of Abdominal Transplant and Immune Evaluation Lab, Baylor College of Medicine, Houston, TX; 2Michael E. DeBakey Department of Surgery, Division of Abdominal Transplantation and Division of Hepatobiliary Surgery, Baylor College of Medicine, Houston, TX; 3Department of Transplant Nephrology, Baylor St Luke's Medical Center, Houston, TX

    Background: Simultaneous liver and kidney transplantation (SLKT) remains as the gold standard for patients with chronic renal and liver diseases. Pre-transplant donor-specific antibody (DSA) to…
  • 2017 American Transplant Congress

    National Variation in Liver Transplant Immunosuppression in the U.S..

    M. Nazzal,1 R. Ouseph,1 M. Schnitzler,1 Z. Zhang,1 D. Axelrod,2 D. Segev,3 A. Naik,4 H. Randall,1 D. Brennan,5 B. Kasiske,6 G. Hess,7 T. Alhamad,5 K. Lentine.1

    1St Louis Univ, St Louis; 2E Carolina Univ, Greenville; 3Johns Hopkins, Baltimore; 4U Michigan, Ann Arbor; 5Washington Univ, St Louis; 6SRTR, Minneapolis; 7Symphony Health, Philadelphia

    Variation in immunosuppression (ISx) for liver transplant (LTx) across US programs has not been described. We examined a novel database integrating national registry and pharmacy…
  • 2017 American Transplant Congress

    Identification of a Stable Gene Signature of Transplant Tolerance to Liver Allograft by Meta-Analysis.

    G. Gu, H. Hang, Q. Xia.

    Department of Hepatic Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China

    Transplant tolerant to a liver graft display a specific blood cell transcriptional pattern but results from six different studies were not consistent, raising the question…
  • 2017 American Transplant Congress

    Optimizing Support for Living Kidney Donors: Insights from a Prospective Study.

    D. Dobosz,1 C. Thiessen,1 S. Li,1 K. Yu,1 J. Gannon,1 K. Kennedy,3 D. Gray,2 A. Mussell,2 P. Reese,2 E. Gordon,3 S. Kulkarni.1

    1Yale U, New Haven; 2U Pennsylvania, Philadelphia; 3Northwestern U, Chicago

    PurposeTo assess how potential living kidney donors (LKDs) perceived support from the transplant team and areas for improvement.MethodsWe conducted a prospective, longitudinal study of individuals…
  • 2017 American Transplant Congress

    Live Donor (LDTx) HIV(+) Kidney Transplantation Improves Allograft Survival vs. Deceased Donor (CRD) Transplantation.

    G. Malat, D. Lee, K. Ranganna, S. Talluri, L. Levin Mizrahi, M. Harhay, C. Culkin, S. Guy.

    Drexel University College of Medicine, Philadelphia

    Hahnemann University Hospital has performed 113 kidney transplants in HIV(+) recipients. We sought to analyze the impact of HIV(+) LDTx on allograft survival.Methods: The HIV(+)…
  • 2017 American Transplant Congress

    Comparing Renal Function Recovery and Long Term Outcomes in Recipients of Standard and Expanded Criteria Donor Kidney Transplants.

    S. Sandal, M. Cantarovich, S. Paraskevas, N. Almaghrawi, P. Chaudhury, J. Tchervenkov.

    McGill University Health Center, Montreal, Canada

    Several donor and recipient characteristics are associated with adverse kidney transplantation (KT) outcomes. Our group has previously shown that based on the donor's terminal creatinine,…
  • 2017 American Transplant Congress

    A Markov Model for Transplant & Renal Outcomes After Liver & Simultaneous Liver-Kidney Transplants.

    X. Cheng,1 W. Kim,2 J. Tan,1 J. Goldhaber-Fiebert.3

    1Div Nephrology, Stanford U, Palo Alto; 2Div Gastroenterology & Hepatology, Stanford U, Palo Alto; 3Ctr Health Policy, Stanford U, Palo Alto

    The Organ Procurement and Transplant Network (OPTN) will implement a set of clinical criteria for simultaneous liver-kidney (SLK) transplant eligibility. Our aim is to build…
  • 2017 American Transplant Congress

    The Forgotten Element of KAS: A2 to B Transplantation Reduces Waiting Time for Blood Group B Patients by 20%.

    A. Gilbert, S. Radomski, A. Langeberg, B. Diedrich, S. Rosen-Bronson, D. Li, M. Awwad, M. Grafals, J. Moore, J. Verbesey, P. Abrams, S. Ghasemian, M. Cooper.

    Medstar Georgetown Transplant Institute, Washington, DC

    Introduction Since the implementation of the Kidney Allocation System (KAS) in 2014 blood group B patients have been able to receive priority for blood group…
  • 2017 American Transplant Congress

    Uptake of Extracellular Mitochondria Activates Human Endothelial Cells That Stimulate Alloreactive Effector T Cell Responses.

    T. Brennan,1 F. Feng,1 L. Lin,1 M. Song,1 Q.-J. Li,2 A. Kirk,1,2 H. Xu.1

    1Surgery, Duke University, Durham, NC; 2Immunology, Duke University, Durham, NC

    Introduction: Vascular endothelial cells (VECs), the initial barrier between host immunity and donor allograft tissue, play a critical role in allograft rejection. We investigated the…
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