Am J Transplant, Volume 17, Suppl 3 Archives - Page 33 of 181 - ATC Abstracts

2017 American Transplant Congress
Depletion of T-Cells from G-CSF Mobilized Human PBMC Prevents Acute GVHD in NSG Mice.
Y. Huang, H. Xu, A. Merchak, A. Chhabra, Y. Wen, L. Kahn, S. Ildstad.
Institute for Cellular Therapeutics, University of Louisville, Louisville, KY
Allogeneic HSC transplantation is commonly utilized for the treatment of hematologic malignancies and autoimmune diseases. However, allogeneic HSC transplantation is limited by potential for the…
2017 American Transplant Congress
Donor-Derived Cell-Free DNA Parallels Increases in Donor Specific Antibodies in Pediatric Kidney Transplant Recipients.
D. Stoltz,¹ A. Brubaker,¹ M. Grskovic,² R. Woodward,² A. Gallo.¹
¹Surgery, Stanford University, Palo Alto, CA; ²CareDx, Brisbane, CA
Introduction: Anti-HLA antibody screening is a critical component of post-kidney transplant surveillance. Existing protocols and treatment plans are not standard/consistent across institutions. As increasing numbers…
2017 American Transplant Congress
Omega 3 Attenuates Ischemia Reperfusion Renal Injury via Enhancement of Autophagy Flux.
J.-J. Kim,¹ J. Jeong,² D. Choi,³ K. Na,³ K. Lee.³
¹Chungnam National University, Anatomy, Daejeon, Korea; ²Chungnam National University, Department of Medical Science, Daejeon, Korea; ³Chungnam National University, Nephrology, Daejeon, Korea
Purpose: Omega 3 fatty acid showed the protective effect against various renal injuries. Recently, it is reported that Omega 3 regulates the autophagy. Using fat-1…
2017 American Transplant Congress
Objective Assessment of Graft Metabolism and Function During Ex Vivo Liver Perfusion.
J. Echeverri,¹ S. Cleland,² M. Kaths,¹ I. Linares,¹ R. Roizales,¹ N. Goldaracena,¹ D. Kollmann,¹ M. Hamar,¹ P. Urbanellis,¹ S. Ganesh,¹ O. Adeyi,³ D. Grant,¹ N. Selzner,⁴ M. Wasowicz,² M. Selzner.¹
¹Multi-Organ Transplant Program, Department of Surgery, University of Toronto - Toronto General Hospital, Toronto, ON, Canada; ²Multi-Organ Transplant Program, Department of Anesthesia, University of Toronto - Toronto General Hospital, Toronto, ON, Canada; ³Multi-Organ Transplant Program, Department of Pathology, University of Toronto - Toronto General Hospital, Toronto, ON, Canada; ⁴Multi-Organ Transplant Program, Department of Medicine, University of Toronto - Toronto General Hospital, Toronto, ON, Canada
During EVLP no objective perfusion parameters have been found to predict outcome after transplantation.Methods: Livers with 4grades of injury were perfused for 4 hours and…
2017 American Transplant Congress
Prevalence of CYP3A Genomic Variances and Impact on Tacrolimus Dosing Requirements in Kidney Transplant Recipients in Eastern North Carolina.
T. Asempa,¹ S. Hudson,² L. Rebellato,² A. Maldonado.¹
¹Vidant Medical Center, Greenville, NC; ²East Carolina University, Greenville, NC
BACKGROUND: African American (AA) patients are substantially more likely to express CYP3A5. Presence of CYP3A5 polymorphisms is an important pharmacotherapeutic consideration due to the extensive…
2017 American Transplant Congress
A Novel, Dose-Adjusted Tacrolimus Trough Concentration (TTC) Model for Prediction and Variance Estimation.
J. Kim,¹ S. Wilson,¹ N. Undre,² S. Fei,¹ R. Kristy,¹ J. Schwartz.¹
¹Astellas Pharma Global Development, Inc., Northbrook, IL; ²Astellas Pharma Global Development, Inc., Chertsey, United Kingdom
Given that a high tacrolimus (tac) intrapatient variability (IPV) increases the risk for a poor kidney transplant (tx) outcome, some experts advocate routine IPV monitoring…
2017 American Transplant Congress
The Efficacy and Safety of Plaquenil in Kidney Transplants Patients with Lupus.
S. Rhazouani,^1,4 S. Anwar,² D. Brennan,¹ K. Lentine,³ K. Venkatachalam,¹ A. Malone,¹ T. Alhamad.¹
¹Washington University, Saint Louis; ²Freman Hospital, New Castle, United Kingdom; ³Saint Louis University, Saint Louis; ⁴Cleveland Clinic Foundation, Weston
Background: Hydroxychloroquine, also known as Plaquenil ( PLQ) is an antimalarial drug with immunomodulatory action. Recent studies have demonstrated a protective effect of PLQ in…
2017 American Transplant Congress
Detection of Shared and Distinct Gene Expression Signatures in Tissue and Urine During Acute Rejection of Kidney Grafts.
K. Keslar,¹ A. Zmijewska,² J. Chen,² K. Newell,³ P. Heeger,⁴ R. Mannon,² R. Fairchild.¹
¹Department of Immunology, Cleveland Clinic, Cleveland, OH; ²Department of Medicine, Division of Nephrology, University of Alabama at Birmingham, Birmingham, AL; ³Department of Surgery, Emory University, Atlanta, GA; ⁴Department of Medicine, Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY
A major goal of the Clinical Trials in Organ Transplantation (CTOT) studies is the identification of biomarkers that predict or diagnose acute graft rejection in…
2017 American Transplant Congress
Cardiovascular Disease in Japanese Kidney Transplant Recipients.
M. Okumi, K. Unagami, D. Fujimori, K. Hata, T. Hirai, H. Ishida, K. Tanabe, Japan Academic Consortium of Kidney Transplantation (JACK).
Urology, Tokyo Women's Medical University, Tokyo, Japan
BackgroundGlobally, among kidney transplant recipients (KTRs), cardiovascular diseases (CVDs) have been the most frequent cause of death with a preserved transplant kidney function, referred to…
2017 American Transplant Congress
The Effects of Aspirin on Major Adverse Cardiac Events and Kidney Allograft Outcomes: A Meta-Analysis.
W. Cheungpasitporn, C. Thongprayoon, D. Mitema, M. Mao, W. Kittanamongkolchai, M. Gonzalez-Suarez, S. Erickson.
Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN
BACKGROUND: The use of aspirin in chronic kidney disease patients has been shown to reduce myocardial infarction but may increase major bleeding. However, its effects…