ATC Abstracts

American Transplant Congress abstracts

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  • 2017 American Transplant Congress

    Effective Targeting Plasma Cells with Daratumumab (Anti-CD38) and Mozobil (Anti-CXCR4) in a Sensitized Non-Human Primate Model.

    J. Kwun,1 B. Ezekian,1 M. Manook,1 E. Branum,1 V. Curfman,1 J. Park,1,2 K. Freishlag,1 J. Yoon,1 S. Knechtle.1

    1Surgery, Duke Transplant Center, Durham, NC; 2Surgery, Samsung Medical Center, Seoul, Korea

    [Introduction] The presence of donor-specific antibodies (DSA) leads to antibody-mediated rejection (AMR) and decreased graft survival. Therefore efforts continue to be made to reduce DSA…
  • 2017 American Transplant Congress

    Can Viral Load Be Used as a Surrogate Marker in Clinical Studies of Cytomegalovirus in Solid Organ Transplantation: A Systematic Review and Metaanalysis.

    Y. Natori,1 A. Alghamdi,1 D. Kumar,1 V. Miller,2 P. Ljungman,3 S. Husain,1 A. Humar.1

    1Multi-Organ Transplant Program, UHN, Toronto, Canada; 2UC-Berkeley, Berkeley; 3Karolinska Inst., Solna, Sweden

    Background: Regulatory trials assessing CMV drugs have utilized symptomatic CMV disease as the primary endpoint. However CMV disease occurs infrequently, CMV syndrome is nonspecific, and…
  • 2017 American Transplant Congress

    De Novo Donor-Specific Antibodies After Allograft Nephrectomy.

    G. Lucisano,1 P. Brookes,2 E. Santos-Nunez,2 N. Firmin,2 N. Gunby,2 S. Hassan,1 A. Gueret-Wardle,1 M. Willicombe,1 D. Taube.1

    1Renal and Transplant Centre, Imperial College Healthcare NHS Trust, London, United Kingdom; 2Histocompatibility and Immunogenetics, Imperial College Healthcare NHS Trust, London, United Kingdom

    Introduction: although the development of donor-specific antibodies (DSAs) is a known event after allograft nephrectomy (Nx), there are few studies describing the tempo, class and…
  • 2017 American Transplant Congress

    Longitudinal Study of Donor Specific Antibodies in a Pediatric Kidney Transplant Population; Response to Optimization of Anti-Proliferative Therapy.

    A. Rounds, M. Moss, M. Bock, J. Goebel.

    Children's Hospital Colorado, Aurora, CO

    In 2015 we implemented surveillance donor-specific antibody (DSA) monitoring in our pediatric kidney transplant recipients (pKTR); we found that in stable pKTRs (i.e. no changes…
  • 2017 American Transplant Congress

    20 and 25-Year Outcomes Following Pediatric Liver Transplantation.

    W. Andrews,1 N. Gupta,2 U. Ekong.3

    1Ped. Surgery, Children's Mercy Hospital, Kansas City, MO; 2Div. Peds. Gastro., Emory, Atlanta, GA; 3Div. Peds. Gastro., Yale, New Haven, CT

    Background: Improved 1,5, & 10- year survival following Pediatric Liver Transplantation (LT) has been demonstrated. However 20 and 25-year patient and graft outcomes (including cause…
  • 2017 American Transplant Congress

    Substance Abuse in Acute Liver Failure: Time to Talk About Opiates.

    M. Jesse, N. Rebhan, A. Yoshida, D. Moonka, A. Eshelman, M. Abouljoud, M. Rizzari.

    Transplant Institute, Henry Ford Health System, Detroit

    Purpose: Prescription opiate utilization is on the rise. Research on acute liver failure (ALF) has focused on acetaminophen (APAP) overdose or other medical etiologies but…
  • 2017 American Transplant Congress

    Host-Derived, Intragraft Dendritic Cells Are Extensively Cross-Dressed by Donor MHC.

    A. Hughes, H. Dai, A. Williams, M. Oberbarnscheidt, A. Morelli, F. Lakkis.

    Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsbugh, PA

    Host dendritic cells (DC) are the primary driver of transplant rejection in secondary lymphoid tissues where they activate alloreactive T cells. Directly alloreactive T cells…
  • 2017 American Transplant Congress

    Outcomes Following Hysterectomy in Kidney Transplant Recipients.

    S. DiBrito, I. Olorundare, C. Haugen, C. Holscher, L. Kucirka, D. Segev, J. Garonzik-Wang.

    Surgery, JHU, Baltimore

    Nearly 1/3 of American women, including kidney transplant recipients (KTR), undergo hysterectomy in their lifetime, making it one of the most common female-specific surgeries performed.…
  • 2017 American Transplant Congress

    Kidney Quality Dramatically Influences Patient and Death Censored Graft Survival in SLK Recipients.

    T. Zens, J. Danobeitia, P. Stahler, G. Leverson, R. Redfield, A. D'Alessandro, L. Fernandez.

    Department of Transplant Surgery, University of Wisconsin, Madison, WI

    Introduction: Renal grafts used in simultaneous kidney liver (SLK) transplants are allocated on “center based” arbitrary clinical criteria without entering the kidney allocation algorithm. The…
  • 2017 American Transplant Congress

    Protease Inhibitor-Based Regimens Are Associated with Inferior Outcomes in HIV-Infected Kidney Transplant Recipients.

    B. Shelton,1 D. Sawinski,2 R. Reed,1 P. MacLennan,1 S. Mehta,1 J. Locke.1

    1University of Alabama at Birmingham, Birmingham; 2University of Pennsylvania, Philadelphia

    Background: Excellent outcomes have been demonstrated among HIV-infected kidney transplant (KT) recipients when HIV infection is well-controlled. Protease inhibitors (PI) have significant drug-drug interactions with…
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