Am J Transplant, Volume 17, Suppl 3 Archives - Page 29 of 181 - ATC Abstracts

2017 American Transplant Congress
Nonmelanoma Skin Cancer Rates Are Not Affected by Chronic HIV(+) or HCV(+) Infection in Organ Transplant Recipients.
K. Nadhan, E. Usedom, S. Shipman, A. Doyle, G. Malat, E. Buchanan, C. Chung.
Dermatology, Drexel, Philadelphia
Purpose: HIV and HCV are two immune dysregulatory processes that may exacerbate the risk of nonmelanoma skin cancer (NMSC) in organ transplant recipients (OTR), a…
2017 American Transplant Congress
Patients with Renal Failure Have a pERK-Dependent Defective TCR-Mediated Activation of CD4⁺ T Cells.
L. Huang, N. Litjens, N. Kannegieter, M. Klepper, C. Baan, M. Betjes.
Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands
Introduction Patients with end-stage renal disease (ESRD) have an impaired immune response with a prematurely aged T cell system. Mitogen-activated protein kinases (MAPKs) including extracellular…
2017 American Transplant Congress
Kidney Recipients with 10 Year Belatacept-Treatment Display an Altered T Cell Subset Composition and Low Plasma Cytokine Levels Compared to Matched Patients with CNI-Based Immunosuppression.
C. Falk,¹ C. Neudörfl,¹ A. Scherf,¹ K. Daemen,¹ J. Keil,¹ J. Klempnauer,² F. Lehner,² G. Grannas.²
¹Institute of Transplant Immunology, IFB-Tx, MHH, Hannover, Germany; ²Department of Abdominal, Visceral and Transplantation Surgery, MHH, Hannover, Germany
Introduction/BackgroundMore than 10 years ago, Belatacept (Bela)-based immunosuppression was investigated in the BENEFIT trial of kidney transplantation (KTx) compared to CNI-based immunosuppression. Bela inhibits T…
2017 American Transplant Congress
SIRPα⁺ DCs and the Time-Dependent CD4⁺CD8⁺ Double Positive T Cell Infiltration in Accepted Renal Allografts.
T. Ashry,^1,2 C. Yang,² B. Jiang,² D. Ndishabandi,² P. Russel,^1,2 R. Colvin,^1,2 J. Madsen,^1,2 A. Alessandrini.^1,2
¹HMS, Boston; ²MGH, Boston
IntroductionIn 2015 Overgaard and colleagues proposed that double positive T (DPT) cells, usually unique to the thymus, represent more than a developmental phase as extrathymic…
2017 American Transplant Congress
Impact of Complement Component 3 Single Nuclear Polymorphisms on Renal Transplant Recipients with Antibody-Mediated Rejection.
Z. Wang, Z. Han, J. Tao, R. Tan, M. Gu.
Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Impact of complement component 3 single nuclear polymorphisms on renal transplant recipients with antibody-mediated rejectionZijie Wang, Zhijian Han, Jun Tao, Ruoyun Tan, Min GuDepartment of…
2017 American Transplant Congress
Donor-Derived Cell-Free DNA Is a Dynamic Biomarker of Active Rejection in Kidney Allografts.
D. Brennan,¹ J. Bromberg,² E. Poggio,³ D. Hiller,⁴ J. Sninsky,⁴ R. Woodward,⁴ J. Yee,⁴ R. Bloom.⁵
¹Washington University, St. Louis, MO; ²University of Maryland, Baltimore, MD; ³Cleveland Clinic, Cleveland, OH; ⁴CareDx, Brisbane, CA; ⁵University of Pennsylvania, Philadelphia, PA
Purpose: Donor-derived cell-free DNA (dd-cfDNA) has shown promise as a biomarker in identification of allograft rejection. Here we report on the changes in dd-cfDNA prior…
2017 American Transplant Congress
Incidence and Clinical Outcomes of Mycobacterium tuberculosis Infections Following Renal Transplantation in Endemic Country.
K. Jutivorakool, J. Vanichanan, G. Suwanpimolkul, Y. Avihingsanon, N. Townamchai.
Division of Infectious Diseases, Department of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand; Division of Nephrology, Department of Medicine, Chulalongkorn University, Bangkok, Thailand
Background: Most cases of Tuberculosis (TB) in solid organ transplant recipients are caused by reactivation of a latent infection after initiation of immunosuppressive therapy. This…
2017 American Transplant Congress
Outcomes Following Reduction of Immunosuppression in Solid Organ Transplant Recipients with Cryptococcosis.
P. Bryant,¹ P. Pappas,¹ C. Huisingh,¹ R. Mannon,¹ J. Locke,¹ K. Wille,¹ D. Eckhoff,¹ J. Tallaj,¹ J. Baddley.^1,2
¹Comprehensive Transplant Institute, University of Alabama at Birmingham, Birmingham, AL; ²VAMC, Birmingham, AL
Background: Cryptococcosis (crypto) is the third most common fungal infection in solid organ transplant (SOT) recipients. Although reduction of immunosuppression (IS) may improve patient outcomes…
2017 American Transplant Congress
Normothermic Ex-Vivo Kidney Perfusion Improves Function of Extreme Marginal Renal Grafts Subjected to Prolonged Ischemia.
P. Urbanellis,¹ M. Hamar,¹ I. Linares,¹ D. Kollmann,¹ C. Cassol,² R. John,² P. Yip,¹ I. Mucsi,¹ A. Ghanekar,¹ D. Bagli,³ D. Grant,¹ L. Robinson,⁴ M. Selzner.¹
¹Multi-Organ Transplant Program, Department of Surgery, Toronto General Hospital, University Health Network, Toronto, ON, Canada; ²Laboratory Medicine and Pathobiology, Toronto General Hospital, University Health Network, Toronto, ON, Canada; ³Departments of Surgery (Urology) and Physiology, The Hospital for Sick Children, Toronto, ON, Canada; ⁴Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada
Background: Normothermic ex-vivo kidney perfusion (NEVKP) is an emerging technique for renal graft preservation. We investigated whether NEVKP could promote improved marginal graft function compared…
2017 American Transplant Congress
Outcome and Risk Factors of Recurrent Focal Segmental Glomerulosclerosis After Kidney Transplantation.
G. Chen, C. Wang, Z. Wu, J. Zhang, S. Yu, C. Wang, J. Qiu, L. Chen.
Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Background Recurrent focal segmental glomerulosclerosis(FSGS) is common after kidney transplantation . We conducted a retrospective cohort study with the aim to investigating the long-term outcome…